EVALUATION OF FORMULATED TRANSDERMAL PATCHES
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Keywords
Transdermal Patch, In vitro drug study, Transdermal
Abstract
The goal of this study was to use the solvent casting process to create a matrix-type transdermal treatment system comprising the medication aceclofenac and various ratios of hydrophilic (hydroxyl propyl methyl cellulose) and hydrophobic (methyl cellulose) polymeric systems. The physical characteristics of developed transdermal patches were assessed, including their thickness, weight fluctuation, medication content, flatness, tensile strength, folding durability, moisture content %, and water vapour transfer rate. In this work, Cefdinir was utilized to make transdermal patches out of a variety of polymers, including Cellulose derivatives, polyvinyl alcohol, polyethylene, polypropylene, polyvinylpyrrolidone, and polymethyl methacrylate, all of which had varying concentrations. Using PEG-400 as a plasticizer, patches were created using the solvent evaporation process. Transdermal films that had been developed were tested physically for things like thickness, weight fluctuation, drug content, flatness, tensile strength, folding endurance, and moisture content as a percentage. The physical stability of all developed formulations was satisfactory.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Abhishek Pandey
Department of Chemistry and Pharmacy Rani Durgavati Vishwavidyalaya Jabalpur (Madhya Pradesh)
Shailesh Gupta
Mansarovar Global University Sehore (Madhya Pradesh)