Assessment Of Serum Levels of Zeb2 and Fat10 and Tumor Necrosis Factor-Alpha as Potential Novel Biomarkers in Breast Cancer Patients
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Five Minute Preceptor, critical thinking, nursing profession students
Abstract
Background: Breast cancer is the primary and most frequent type of cancer that kills women, ranking fifth among all malignancies that result in fatalities globally and second behind lung cancer in terms of prevalence.
Objective: In this study, zeb 2 and fat10 proteins and pro-inflammatory cytokines (TNF-α) were evaluated in Iraqi women with breast cancer.
Patients and methods: In this study, serum concentrations of zeb 2 ,fat 10 and TNF-α were determined using samples from 90 Iraqi women (60 patients and 30 healthy volunteers) Among them are healthy and patients, premenopausal and postmenopausal woman .
Results: According to the findings of the current study, FAT10 and TNF- α were both considerably elevated in breast cancer patients (P<0.05), and they also had a tight relationship, and ZEB2 was also high on the probability level ( P < 0.01).
Conclusions: This study discovered a link between elevated serum levels of pro-inflammatory cytokines TNF-α, ZEB2, and FAT10
References
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