POSSIBLE CARBAMAZEPINE TOXICITY WITH TERBINAFINE

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Navdeep S Baath
Creighton University Department of Psychiatry, Omaha NE

Jennifer Hong
Creighton University Department of Psychiatry, Omaha NE

S Pirzada Sattar
1 Creighton University Department of Psychiatry, Omaha NE, 2Omaha Veterans Affairs Medical Center (VAMC), Omaha, NE, 3Sanford School of Medicine, University of South Dakota & Avera McKennan Research Institute, Sioux Falls, SD.

Keywords

Terbinafine, carbamazepine drug-drug interaction

Abstract

Objective


To report a case of carbamazepine and terbinafine interaction resulting in an elevated level of carbamazepine and associated symptoms of toxicity.


 


Case summary


A 50-year-old Caucasian man developed an elevated carbamazapine level after starting terbinafine, which caused symptoms of toxicity with gait ataxia, dizziness and falls.


 


Discussion


This is a first report of a drug-drug interaction between carbamazapine and terbinafine. Although the mechanism for this interaction is not fully known, it  is suspected that terbinafine decreased the metabolism of carbamazapine and led to increased levels that continued even days after the carbamazapine had been stopped. The Naranjo Scale suggests that this was a probable interaction (score 6).


 


Conclusions


While several drug-drug interactions have been reported with carbamazapine, there are no previous reports of its interaction with terbinafine. Prescribers should exercise caution when prescribing these medications together.

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Dec 8, 2018

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How to Cite
S Baath, N., Hong, J., & Sattar, S. P. (2018). POSSIBLE CARBAMAZEPINE TOXICITY WITH TERBINAFINE. Journal of Population Therapeutics and Clinical Pharmacology, 13(2). https://mail.jptcp.com/index.php/jptcp/article/view/124
Issue
Vol. 13 No. 2 (2006)
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Articles
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How to Cite

S Baath, N., Hong, J., & Sattar, S. P. (2018). POSSIBLE CARBAMAZEPINE TOXICITY WITH TERBINAFINE. Journal of Population Therapeutics and Clinical Pharmacology, 13(2). https://mail.jptcp.com/index.php/jptcp/article/view/124