THYROID STATUS IN GESTATIONAL DIABETES MELLITUS- A CASE CONTROL STUDY.
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Keywords
Gestational diabetes mellitus, thyroid-stimulating hormone, free triiodothyronine, free thyroxine, thyroid dysfunction, pregnancy.
Abstract
Introduction: Gestational diabetes mellitus (GDM) is a significant pregnancy complication associated with maternal and fetal risks. Thyroid dysfunction, particularly altered thyroid hormone levels, has been implicated in various pregnancy-related disorders, including GDM.
Materials and Methods: This case-control study aimed to investigate the relationship between thyroid function markers—thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4)—and GDM in pregnant women. A total of 120 pregnant women (60 with GDM and 60 controls) were enrolled in the study, and demographic, biochemical, and clinical data were collected. Blood samples were analyzed for fasting blood sugar (FBS) levels and thyroid function markers (TSH, FT3, FT4).
Results: The results showed a significant difference in FBS levels between GDM and control groups, confirming the presence of hyperglycemia in GDM patients. However, no significant differences were observed in TSH, FT3, and FT4 levels between the two groups. While some studies have suggested an association between thyroid dysfunction and GDM, our findings indicate that thyroid hormone levels did not significantly vary between women with GDM and those without.
Conclusion: These results suggest that thyroid dysfunction may not directly contribute to GDM risk in the studied population. However, the potential role of thyroid autoimmunity and subclinical thyroid dysfunction warrants further investigation. Larger, longitudinal studies are needed to better understand the complex relationship between thyroid function and GDM.
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Gulshan Prakash
Assistant Professor, Dept. of Biochemistry, Pt. B D Sharma PGIMS Rohtak
Sumit Dokwal
Professor, Dept. of Biochemistry, Pt. B D Sharma PGIMS Rohtak
Ujyala Singh
PG students, Dept. of Biochemistry, Pt. B D Sharma PGIMS Rohtak
Soniya Dahiya
Associate Professor, Dept. of Obstetrics and Gynaecology, Pt. B D Sharma PGIMS Rohtak
Spoorthi S
PG students, Dept. of Biochemistry, Pt. B D Sharma PGIMS Rohtak
Reetu
PG students, Dept. of Biochemistry, Pt. B D Sharma PGIMS Rohtak
Rakesh Kumar
PG students, Dept. of Biochemistry, Pt. B D Sharma PGIMS Rohtak
Bhavika Khemani
PG students, Dept. of Biochemistry, Pt. B D Sharma PGIMS Rohtak
Sabiya Parveen
PG students, Dept. of Biochemistry, Pt. B D Sharma PGIMS Rohtak