Dyslipidemia and Other Parameters in Women With Pregnancy Induced Hypertension
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Abstract
Several investigations have confirmed changes in lipid profiles and other markers (IL-6,CRP ) in women with pregnancy-induced hypertension (PIH). Although, the cause-and-effect correlations between these lipid profiles and other markers with the PIH are yet unknown.
Aim: To study the relationship of serum lipid profile ,C- reactive protein (CRP )and interleukin-6 (IL-6 ) with pregnancy-induced hypertension.
Patients and Methods: A cross- sectional study, was done on 60 pregnant women attending with pregnant induce hypertension (PIH) treated in General Salah Alden Hospital in Tikrit city-Iraq, from January 2021 to April 2021. Other 60 normal pregnant women, at the same period, were selected as a control group. The average age of the participants was (27.1±5.0) years, all the taken blood samples , were examined for lipid profile, CRP and IL-6.
Results: Statistically show significant differences in IL-6 level and CRP. Whereas Lipid profile(TG ,LDL-C HDL-C ,TC and VLDL) were found, also, significant differences in PIH patients as compared to normal controls.
References
1-Dr. Ghada Sayed Youssef. Hypertension in pregnancy, Journal-of-Cardiology-Practice/ Vol. 17, N° 22 - 18 Sep 2019
2- Steer PJ, Little MP, Kold-Jensen T, Chapple J, Elliott P. Maternal blood pressure in pregnancy, birth weight, and perinatal mortality in first births: prospective study. BMJ 2004; 329 doi: https://doi.org/10.1136/bmj.38258.566262.7C (Published 02 December 2004) Cite this as: BMJ 2004;329:1312.
3-Vest AR and Cho LS: Hypertension in pregnancy. Curr Atheroscler Rep. 16:3952014. View Article : Google Scholar : PubMed/NCBI
4-Mangos GJ, Spaan JJ, Pirabhahar S and Brown MA: Markers of cardiovascular disease risk after hypertension in pregnancy. J Hypertens. 30:351–358. 2012. View Article : Google Scholar : PubMed/NCBI
5-Rosengarten D, Blieden LC and Kramer MR: Pregnancy outcomes in pulmonary arterial hypertension in the modern management era. Eur Respir J. 40:1304–1305. 2012. View Article : Google Scholar : PubMed/NCBI
6-Lazzarin N, Desideri G, Ferri C, Valensise H, Gagliardi G, Tiralongo GM and Manfellotto D: Hypertension in pregnancy and endothelial activation: An emerging risk factor for cardiovascular disease. Pregnancy Hypertension. 2:393–397. 2012. View Article : Google Scholar : PubMed/NCBI
7-Repke JT: Hypertension in pregnancy. I. Md Med J. 36:473–475. 1987.PubMed/NCBI
8-Babbette LaMarca,1 Joshua Speed,1 Lillian Fournier Ray,1 Kathy Cockrell,1 Gerd Wallukat,2 Ralf Dechend,2 and Joey Granger1 Int J Infereron Cytokine Mediator Res. 2011 Nov; 2011(3): 65–70. doi: 10.2147/IJICMR.S22329.
9- Mohd. Nawaz , Manish Kumar Verma. Evaluation of Differential Levels of Serum Interleukin-6 in Pre-Eclamptic and Normal Pregnancy Women. International Journal of Physiology, January-March 2020, Vol. 8, No. 1.doi:10.5958/2320-608X. 2020.000116.
10- Firoz T, Magee LA, MacDonell K, Payne BA, Gordon R, Vidler M and von Dadelszen P: Community Level Interventions for Pre-eclampsia (CLIP) Working Group: Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: A systematic review. BJOG. 121:1210–1220. 2014. View Article : Google Scholar : PubMed/NCBI
11- Clausen T, Djurovic S, Henriksen T. Dyslipidemia in early second trimester is a feature of women with early onset preeclampsia. Br J Obstet Gynaecol., 2001; 108: 1081–1087.
12- Cross JC (2003). "The Genetics of Pre-eclampsia: A Feto-placental or Maternal Problem?". Clinical Genetics. 64 (2): 96–103. doi:10.1034/j.1399-0004.2003.00127.x
13- Duckitt K, Harrington D (March 2005). "Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies". BMJ. 330 (7491): 565. doi:10.1136/bmj.38380.674340.E0. PMC 554027. PMID 15743856
14- Dehua Kong, Hui Wang. Yan Liu Hongjun Li, Hongyan Wang Peng Zhu. Correlation between the expression of inflammatory cytokines IL-6, TNF-α and hs-CRP and unfavorable fetal outcomes in patients with pregnancy-induced hypertension . Exper. Therap. Med. 2018;16: 1982-1986.
15-Li Y1,Wang Y2,Ding X3,Duan B3,Li L2,Wang X4.Serum Levels of TNF-α and IL-6 Are Associated With Pregnancy-Induced Hypertension. 12 Apr 2016, 23(10):1402-1408.DOI: 10.1177/1933719116641760 PMID: 27076445
16- Babbette LaMarca, Justin Brewer, and Kedra Wallace. IL-6-induced pathophysiology during pre-eclampsia: potential therapeutic role for magnesium sulfate: Int J Infereron Cytokine Mediator Res. Author manuscript; available in PMC 2011 Nov 30.)
17-Hala T El-Bassyouni, Sahar M Abdel Raouf, Mona K Farag , Wasela M Nawito, Tarek M Salman, Khaled R Gaber. Dysregulation of tumor necrosis factor-α and interleukin-6 as predictors of gestational disorders
MIDDEL EASTJ OF MEDICAL GENETIC .2018 ; V 7 . Issue : 2 .P 112-117
18- Volanakis JE. Human C-reactive protein: Expression, structure, and function. Mol Immunol. 2001;38:189–197. doi: 10.1016/S0161-5890(01)00042-6. [PubMed] [CrossRef] [Google Scholar]
19- Qiu C, Sorensen TK, Luthy DA, Williams MA. A prospective study of maternal serum C-reactive protein (CRP) concentrations and risk of gestational diabetes mellitus. Paediatr Perinat Epidemiol. 2004;18:377–384. doi: 10.1111/j.1365-3016.2004.00578.x. [PubMed] [CrossRef] [Google Scholar
20- Paternoster DM, Fantinato S, Stella A, Nanhornguè KN, Milani M, Plebani M, Nicolini U, Girolami A. C-reactive protein in hypertensive disorders in pregnancy. Clin Appl Thromb Hemost. 2006;12:330–337. doi: 10.1177/1076029606291382. [PubMed] [CrossRef] [Google Scholar]
21 - Sesso HD, Buring JE, Rifai N, et al. C-reactive protein and risk of developing hypertension. JAMA 2003;290:2945.-
22- Delia M. Paternoster, Sara Fantinato, Andrea Stella, Kimta Ngaradoumbe Nanhornguè, Massimo Milani, Mario Plebani, Umberto Nicolini, and Antonio Girolami. C-Reactive Protein in Hypertensive Disorders in Pregnancy ‡ Clinical and Applied Thrombosis/Hemostasis Vol. 12, No. 3, July 2006 330-337 DOI: 10.1177/1076029606291382 © 2006 Sage Publications)
23-Hang Chen, Jun Zhang, Fang Qin, Xinyun Chen, and Xiaojing Jiang. Evaluation of the predictive value of high sensitivity C-reactive protein in pregnancy-induced hypertension syndrome. Exp Ther Med. 2018 Aug; 16(2): 619–622. . doi: 10.3892/etm.2018.6246
24- Elena V. Kuklina,. Hypertension in Pregnancy in the US—One Step Closer to Better Ascertainment and Management. JAMA Network Open, 2020. 3(10):e2019364. doi:10.1001/jamanetworkopen.2020.19364.
25- Lowe (2009) Guidelines for the management of hypertensive disorders of pregnancy 2008. Aust N Z J Obstet Gynaecol 49: 242-246.
26- Ray JG, Diamond P, Singh G, Bell CM (2006) Brief overview of maternal triglycerides as a risk factor for pre eclampsia. BJOG 113: 379-386.
27- Butwick AJ, Druzin ML, Shaw GM, Guo N. Evaluation of US state–level variation in hypertensive disorders of pregnancy. JAMA Netw Open. 2020;3(10):e2018741. doi:10.1001/jamanetworkopen.2020.18741
28- Hubel CA, Lyall F, Weissfeld L, Gandley RE, Roberts JM (1998) Small low-density lipoproteins and vascular cell adhesion molecule-1 are increased in association with hyperlipidemia in preeclampsia. Metabolism. 47: 1281-1288.
29- Cunningham FG, Leveno KJ, Bloom SL (2005) Williams Obstetrics (22nd edition) New York: McGraw-Hill.
30- Vidyabati RK, Davina H, Singh NK, Singh W. Gyaneshwar-Serum β hCG and lipid profile in early second trimester as predictors of Pregnancy induced hypertension. J Obstet Gynecol India, 2010; 60(1): 44- 50
31- Y. Pramoda. Early predictors of PIH: Serum β-HCG and lipid profile Archives of Integrated Medicine, Vol. 7, Issue 2, February, 2020.
2- Steer PJ, Little MP, Kold-Jensen T, Chapple J, Elliott P. Maternal blood pressure in pregnancy, birth weight, and perinatal mortality in first births: prospective study. BMJ 2004; 329 doi: https://doi.org/10.1136/bmj.38258.566262.7C (Published 02 December 2004) Cite this as: BMJ 2004;329:1312.
3-Vest AR and Cho LS: Hypertension in pregnancy. Curr Atheroscler Rep. 16:3952014. View Article : Google Scholar : PubMed/NCBI
4-Mangos GJ, Spaan JJ, Pirabhahar S and Brown MA: Markers of cardiovascular disease risk after hypertension in pregnancy. J Hypertens. 30:351–358. 2012. View Article : Google Scholar : PubMed/NCBI
5-Rosengarten D, Blieden LC and Kramer MR: Pregnancy outcomes in pulmonary arterial hypertension in the modern management era. Eur Respir J. 40:1304–1305. 2012. View Article : Google Scholar : PubMed/NCBI
6-Lazzarin N, Desideri G, Ferri C, Valensise H, Gagliardi G, Tiralongo GM and Manfellotto D: Hypertension in pregnancy and endothelial activation: An emerging risk factor for cardiovascular disease. Pregnancy Hypertension. 2:393–397. 2012. View Article : Google Scholar : PubMed/NCBI
7-Repke JT: Hypertension in pregnancy. I. Md Med J. 36:473–475. 1987.PubMed/NCBI
8-Babbette LaMarca,1 Joshua Speed,1 Lillian Fournier Ray,1 Kathy Cockrell,1 Gerd Wallukat,2 Ralf Dechend,2 and Joey Granger1 Int J Infereron Cytokine Mediator Res. 2011 Nov; 2011(3): 65–70. doi: 10.2147/IJICMR.S22329.
9- Mohd. Nawaz , Manish Kumar Verma. Evaluation of Differential Levels of Serum Interleukin-6 in Pre-Eclamptic and Normal Pregnancy Women. International Journal of Physiology, January-March 2020, Vol. 8, No. 1.doi:10.5958/2320-608X. 2020.000116.
10- Firoz T, Magee LA, MacDonell K, Payne BA, Gordon R, Vidler M and von Dadelszen P: Community Level Interventions for Pre-eclampsia (CLIP) Working Group: Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: A systematic review. BJOG. 121:1210–1220. 2014. View Article : Google Scholar : PubMed/NCBI
11- Clausen T, Djurovic S, Henriksen T. Dyslipidemia in early second trimester is a feature of women with early onset preeclampsia. Br J Obstet Gynaecol., 2001; 108: 1081–1087.
12- Cross JC (2003). "The Genetics of Pre-eclampsia: A Feto-placental or Maternal Problem?". Clinical Genetics. 64 (2): 96–103. doi:10.1034/j.1399-0004.2003.00127.x
13- Duckitt K, Harrington D (March 2005). "Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies". BMJ. 330 (7491): 565. doi:10.1136/bmj.38380.674340.E0. PMC 554027. PMID 15743856
14- Dehua Kong, Hui Wang. Yan Liu Hongjun Li, Hongyan Wang Peng Zhu. Correlation between the expression of inflammatory cytokines IL-6, TNF-α and hs-CRP and unfavorable fetal outcomes in patients with pregnancy-induced hypertension . Exper. Therap. Med. 2018;16: 1982-1986.
15-Li Y1,Wang Y2,Ding X3,Duan B3,Li L2,Wang X4.Serum Levels of TNF-α and IL-6 Are Associated With Pregnancy-Induced Hypertension. 12 Apr 2016, 23(10):1402-1408.DOI: 10.1177/1933719116641760 PMID: 27076445
16- Babbette LaMarca, Justin Brewer, and Kedra Wallace. IL-6-induced pathophysiology during pre-eclampsia: potential therapeutic role for magnesium sulfate: Int J Infereron Cytokine Mediator Res. Author manuscript; available in PMC 2011 Nov 30.)
17-Hala T El-Bassyouni, Sahar M Abdel Raouf, Mona K Farag , Wasela M Nawito, Tarek M Salman, Khaled R Gaber. Dysregulation of tumor necrosis factor-α and interleukin-6 as predictors of gestational disorders
MIDDEL EASTJ OF MEDICAL GENETIC .2018 ; V 7 . Issue : 2 .P 112-117
18- Volanakis JE. Human C-reactive protein: Expression, structure, and function. Mol Immunol. 2001;38:189–197. doi: 10.1016/S0161-5890(01)00042-6. [PubMed] [CrossRef] [Google Scholar]
19- Qiu C, Sorensen TK, Luthy DA, Williams MA. A prospective study of maternal serum C-reactive protein (CRP) concentrations and risk of gestational diabetes mellitus. Paediatr Perinat Epidemiol. 2004;18:377–384. doi: 10.1111/j.1365-3016.2004.00578.x. [PubMed] [CrossRef] [Google Scholar
20- Paternoster DM, Fantinato S, Stella A, Nanhornguè KN, Milani M, Plebani M, Nicolini U, Girolami A. C-reactive protein in hypertensive disorders in pregnancy. Clin Appl Thromb Hemost. 2006;12:330–337. doi: 10.1177/1076029606291382. [PubMed] [CrossRef] [Google Scholar]
21 - Sesso HD, Buring JE, Rifai N, et al. C-reactive protein and risk of developing hypertension. JAMA 2003;290:2945.-
22- Delia M. Paternoster, Sara Fantinato, Andrea Stella, Kimta Ngaradoumbe Nanhornguè, Massimo Milani, Mario Plebani, Umberto Nicolini, and Antonio Girolami. C-Reactive Protein in Hypertensive Disorders in Pregnancy ‡ Clinical and Applied Thrombosis/Hemostasis Vol. 12, No. 3, July 2006 330-337 DOI: 10.1177/1076029606291382 © 2006 Sage Publications)
23-Hang Chen, Jun Zhang, Fang Qin, Xinyun Chen, and Xiaojing Jiang. Evaluation of the predictive value of high sensitivity C-reactive protein in pregnancy-induced hypertension syndrome. Exp Ther Med. 2018 Aug; 16(2): 619–622. . doi: 10.3892/etm.2018.6246
24- Elena V. Kuklina,. Hypertension in Pregnancy in the US—One Step Closer to Better Ascertainment and Management. JAMA Network Open, 2020. 3(10):e2019364. doi:10.1001/jamanetworkopen.2020.19364.
25- Lowe (2009) Guidelines for the management of hypertensive disorders of pregnancy 2008. Aust N Z J Obstet Gynaecol 49: 242-246.
26- Ray JG, Diamond P, Singh G, Bell CM (2006) Brief overview of maternal triglycerides as a risk factor for pre eclampsia. BJOG 113: 379-386.
27- Butwick AJ, Druzin ML, Shaw GM, Guo N. Evaluation of US state–level variation in hypertensive disorders of pregnancy. JAMA Netw Open. 2020;3(10):e2018741. doi:10.1001/jamanetworkopen.2020.18741
28- Hubel CA, Lyall F, Weissfeld L, Gandley RE, Roberts JM (1998) Small low-density lipoproteins and vascular cell adhesion molecule-1 are increased in association with hyperlipidemia in preeclampsia. Metabolism. 47: 1281-1288.
29- Cunningham FG, Leveno KJ, Bloom SL (2005) Williams Obstetrics (22nd edition) New York: McGraw-Hill.
30- Vidyabati RK, Davina H, Singh NK, Singh W. Gyaneshwar-Serum β hCG and lipid profile in early second trimester as predictors of Pregnancy induced hypertension. J Obstet Gynecol India, 2010; 60(1): 44- 50
31- Y. Pramoda. Early predictors of PIH: Serum β-HCG and lipid profile Archives of Integrated Medicine, Vol. 7, Issue 2, February, 2020.
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Apr 12, 2022
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Alaa Saber Shihab, Maha Arshad Hamdi, Abdulhadi Mohamed Jumaa, Mousa Mahmoud Marbut, & Sahar Kamel Jwad. (2022). Dyslipidemia and Other Parameters in Women With Pregnancy Induced Hypertension. Journal of Population Therapeutics and Clinical Pharmacology, 29(01). https://doi.org/10.47750/jptcp.2022.900
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How to Cite
Alaa Saber Shihab, Maha Arshad Hamdi, Abdulhadi Mohamed Jumaa, Mousa Mahmoud Marbut, & Sahar Kamel Jwad. (2022). Dyslipidemia and Other Parameters in Women With Pregnancy Induced Hypertension. Journal of Population Therapeutics and Clinical Pharmacology, 29(01). https://doi.org/10.47750/jptcp.2022.900