2D:4D RATIO VARIATION, BMI AND PULSE RATE AMONG SUBJECTS WITH NORMAL AND ABNORMAL THYROID FUNCTION
Main Article Content
Keywords
TSH, 2D:4D, Ratio, BMI, Pulse Rate
Abstract
Background
The anthropometric measurement, second to fourth digit ratio (2D:4D) is an indication of prenatal testosterone exposure and not influenced by adult hormone levels. Polymorphism of the androgen receptor gene is responsible for individual difference in 2D:4D ratio. The androgen receptors polymorphism and thyroid functions have rarely been compared even though they belong to the same superfamily of receptors.
Objective
To study the relation between 2D:4D ratio, thyroid dysfunction and other metabolic markers like BMI and pulse rate.
Methods
A descriptive cross-sectional study design was conducted in the out-patient General Medicine department, of a tertiary care hospital of central Kerala. This research was conducted after obtaining ethical clearance from the institutional ethical committee. The 2D:4D ration was calculated for each subject. The pulse rate was recorded for each subject. The BMI was calculated for each subject.
Results
There is no significant change in 2D:4D ratio in the hypothyroid subjects (P = 0.944). There is no significant change in 2D:4D ratio in the hyperthyroid subjects (P = 0.987). There was no significant correlation between BMI and 2D:4D ratio. There is no significant change in pulse rate in the hypothyroid subjects (P = 0.657). There is significant change in pulse rate in the hyperthyroid subjects (P = <0.001).
Conclusions
This study did not show significant changes in 2D:4D ratio in subjects with abnormal thyroid function. There was significant increase in P value in BMI calculations in hypothyroid subjects. There was significant decrease in P value in BMI calculations in hyperthyroid subjects. There was significant increase in P value in pulse rate in hyperthyroid subjects. These are comparable to values obtained in similar studies.
References
[2] Meera Jacob M, Avadhani R, Nair B, Nallathamby R. Cross sectional study of second and fourth digit ratio with physical attributes in South Indian population. Int J Anat Res 2015; 3(2): 1133-37.
[3] Tomer Y, Huber A. The etiology of autoimmune thyroid disease: a story of genes and environment. J Autoimmune 2009; 32(3-4): 231-9.
[4] Lutchmaya S, Baron-Cohen S, Raggatt P, Knickmeyer R, Manning JT. 2nd to 4th digit ratios, fetal testosterone and estradiol. Early Hum Dev 2004; 77(1-2): 23-8.
[5] Ventura T, Gomes MC, Pita A, Neto MT, Taylor A. Digit ratio (2D: 4D) in newborns: influences of prenatal testosterone and maternal environment. Early Hum Dev 2013; 89(2): 107-12.
[6] Olsen NJ, Kovacs WJ. Gonadal Steroids and Immunity. Endocr Rev 1996; 17: 369-84.
[7] Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocrine Practice 2012; 18(6): 988-1028.
[8] Taylor PN, Albrecht D, Scholz A, Gutierrez-Buey G, Lazarus JH, Dayan CM, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol 2018; 14: 301-16.
[9] Usha Menon V, Sundaram KR, Unnikrishnan AG, Jayakumar RV, Nair V, Kumar H. High prevalence of undetected thyroid disorders in an iodine sufficient adult south Indian population. J Indian Med Assoc 2009; 107: 72-7.
[10] Kumar R, Thompson EB. The structure of the nuclear hormone receptors steroids. 1999; 64: 310-9.
[11] Carson-Jurica MA, Schrader WT, O’Malley BW. Steroid receptor family: structure and function. Endocr Rev 1990; 11(2):201-20.
[12] Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240(4854):889-95.
[13] Manning JT, Bundred PE, Newton DJ, Flanagan BF. The second to fourth digit ratio and variations in the androgen receptor gene. Evol Hum Behav 2003; 24: 399-405.
[14] Hampson E, Sankar J. S. Re-examining the Manning hypothesis: androgen receptors polymoephism and the 2D:4D digit ratio. Evolution and Human Behaviour 2012; 33(5):557-61.
[15] Zhang C, Dang J, Pei L, Guo M, Zhu H, Qu L, et al. Relationship of 2D:4D finger ratio with androgen receptor CAG and GGN repeat polymorphism. American Journal of Human Biology 2013; 25(1):101-6.
[16] Zheng Z, Cohn MJ. Developmental basis of sexually dimorphic digit ratios. Proceedings of the National Academy of Sciences 2011; 108(39):16289-94.
[17] Jacob M, Avadhani R, Nair B, Nallathamby R, Soman MA. Cross sectional study of second to fourth digit ratio with physical attributes in South Indian population. Int J Anat Res 2015; 3(2):1133-7.
[18] Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1998; 240(4854):889-95.
[19] McIntyre MH. The use of digit ratios as markers for perinatal androgen action. Reproductive Biology and Endocrinology 2006; 4:10.
[20] Oyeyemi BF, Iyiola OA, Oyeyemi AW, Oricha KA, Anifowoshe AT, Alomukii NA. Sexual dimorphism in ratio of second and fourth digits and its relationship with metabolic syndrome indices and cardiovascular risk factors. Journal of Research in Medical Sciences: The official Journal of Isfaham University of Medical Science 2014; 19(3): 234.
[21] Gild ML, Stuart M, Clifton-Bligh RJ, Kinahan A, Handelsman DJ. Thyroid hormone abuse in elite sports: the regulatory challenge. J Clin Endocrinol Metab 2022; 107(9):e3562-73.
[22] Voracek M, Loiblx LM. Scientometric analysis and bibliography of digit ratio (2D:4D) research, 1998-2008. Psychological Reports 2009; 104: 922-56.
[23] Gobrogge KL, Breedlove SM, Klump KL. Genetic and environmental influences on 2D: 4D finger length ratios: A study of monozygotic and dizygotic male and female twins. Archives of Sexual Behavior. 2008; 37(1): 112-8.
[24] Xu Y, Zheng Y. The digital ratio (2D:4D) in China: a meta-analysis. Am J Hum Biol 2015; 27(3): 304-9.
[25] Mirochnik Y, Veliceasa D, Williams L, Maxwell K, Yemelyanov A, Budunova I, et al. Androgen receptor drives cellular senescence. PloS One 2012; 7(3):e31052.
[26] Hoermann R, Midgley JE, Larisch R, Dietrich JW. Homeostatic control of the thyroid–pituitary axis: perspectives for diagnosis and treatment. Front Endocrinol 2015; 6: 177.
[27] Spencer CA, Takeuchi M, Kazarosyan M. Current status and performance goals for serum thyrotropin (TSH) assays. Clinical Chemistry 1996;42(1):140-5.
[28] Danzi S, Klein I. Thyroid disease and the cardiovascular system. Endocrine Metab Clin North Am 2014; 43: 517-28.
[29] Baxter JD, Webb P. Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nature Rev Drug Discov 2009; 8: 308-20.
[30] Brent GA. Mechanisms of thyroid hormone action. J Clin Invest 2012; 122: 3035-43.
[31] Fox CS, Pencina MJ, D’Agostino RB, Murabito JM, Seely EW, Pearce EN, et al. Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med 2008; 168: 587-92.
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Dr. Sona Truman
Associate Professor, Department of Physiology, Government Medical College, Ernakulam, Kerala, India.
Dr. Anand R.L.
Medical Officer, Indo Tibetan Border Police Force, Trivandrum, Kerala, India.