ROLE OF VITAMIN D SUPPLEMENTATION IN THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES
Main Article Content
Keywords
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Abstract
CVDs continue to create a burden in the global disease burden, hence the need to come up with better approaches to tackling the problem. Vitamin D has been related to cardiovascular health in addition to its well-known actions within the skeletal system through its inflammatory effects, effects on endothelial function, and ability to alter the renin-angiotensin-aldosterone system. Nevertheless, these pathways explain the theoretical mechanisms of how vitamin D supplementation prevents and treats CVD, but clinical effectiveness has not been precisely established. To assess the impact of vitamin D in preventing cardiovascular illness and its outcomes, original research before the year 2024, using randomized controlled trials, cohorts, and meta-analysis, was included in this systematic review. As previously mentioned, a PubMed, Scopus, and Web of Science search was performed and screened by quality and relevance. The present study presents an optimistic conclusion in some studies as there is a marked reduction in other risk factors, including blood pressure, lipid profiles, and arterial stiffness. However, other studies support a reduction or lack of benefit in some risk factors. These discrepancies seem to be influenced by differences in study type and duration, participants’ initial vitamin D levels, dose of supplement, and participants. Therefore, whether vitamin D supplementation should be issued universally for CVD prevention and management is still indistinct. This review provides a foundation on which targeted interventions may be designed and developed and demonstrates that more research is needed into the doses that might be effective and the patients most likely to benefit from them. Knowledge of the specifics of how vitamin D works in cardiovascular disease could be helpful in clinical guidelines and could help progress ways to limit global CVD.
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Jan 03, 2025
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Gana Ali Ahmad Tahmaz, Hind Saleh Alhammadi, Judy Al Hussami, Asia Abdalla Shaheen Mohamed Abdalla, Asal Ahmed Mohammed Al Azzawi, Arij A A A A Alasfour, Moaz Osama Omar Mohammed, Dr Iqra Tahir, Dr Sadaf Qureshi, & Lanya Abdulwahab Mustafa. (2025). ROLE OF VITAMIN D SUPPLEMENTATION IN THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES. Journal of Population Therapeutics and Clinical Pharmacology, 32(1), 16-37. https://doi.org/10.53555/knw3yw30
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Author Biographies
Gana Ali Ahmad Tahmaz
University of sharjah, College of Medicine
Hind Saleh Alhammadi
University of Sharjah, College of Medicine
Judy Al Hussami
Gulf Medical University, College of Medicine
Asia Abdalla Shaheen Mohamed Abdalla
University of Sharjah, College of Medicine
Asal Ahmed Mohammed Al Azzawi
University of Sharjah, College of Medicine
Arij A A A A Alasfour
University of Sharjah - College of Medicine
Moaz Osama Omar Mohammed
Ras Al Khaimah Health and Science University
Dr Iqra Tahir
Independent Medical College Faisalabad
Dr Sadaf Qureshi
LUMHS
Lanya Abdulwahab Mustafa
University of Sharjah, College of Medicine
How to Cite
Gana Ali Ahmad Tahmaz, Hind Saleh Alhammadi, Judy Al Hussami, Asia Abdalla Shaheen Mohamed Abdalla, Asal Ahmed Mohammed Al Azzawi, Arij A A A A Alasfour, Moaz Osama Omar Mohammed, Dr Iqra Tahir, Dr Sadaf Qureshi, & Lanya Abdulwahab Mustafa. (2025). ROLE OF VITAMIN D SUPPLEMENTATION IN THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES. Journal of Population Therapeutics and Clinical Pharmacology, 32(1), 16-37. https://doi.org/10.53555/knw3yw30