TO STUDY THE EFFECTS OF 0.5% TOPICAL TIMOLOL ON HEART RATE AND BLOOD PRESSURE IN PATIENTS SUFFERING FROM OPEN ANGLE GLAUCOMA-- A CROSS-SECTIONAL STUDY
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Keywords
Systolic Blood Pressure, 0.5% Topical Timolol Maleate, Primary Open Angle Glaucoma, mm Hg at Schiotz, Diastolic Blood Pressure
Abstract
Background: This study was done for evaluation of effects of 0.5% topically used timolol maleate eye drop on heart rate & systemic blood pressure as pre-treatment and after- treatment in patients who were suffering from primary open angle glaucoma.
Methods: Total 60 patients were randomly selected and equally divided into group I (n=30) and group II (n=30). Group I – IOP between 20 to 30 mm Hg at Schiotz. Group II – IOP between 31 to 40 mm Hg at Schiotz. Each group was further divided into two subgroups, IB and IIB. Subgroup IB and IIB included those on timolol maleate (0.5% topical) administered one drop twice daily for 24 weeks. All 60 patients were evaluated for heart rate and blood pressure examination at the interval of 2nd, 4th, 6th, 8th, 10th, 12th, 14th, 16th, 18th, 20th and 24th weeks. Adverse effects of the drug during study period were also noted. Mean +- SD, t value, p value were analysed by graph pad software.
Results: A mean pre-treatment heart rate was 78.17 ± 3.12 beats / min and after at the end of 24 weeks of treatment there was a mean reduction of 4.0 ± 2.26 beats/min when 0.5% topical timolol maleate eye drop was induced. A mean pre-treatment systolic and diastolic blood pressure were 131.0±10.69 mm Hg and 85.86±5.69 mm Hg respectively. There was a fall of 5.0 ± 3.48 mm Hg of systolic blood pressure and 3.29±2.78 mm Hg of diastolic blood pressure at the end of 24 weeks after treatment with 0.5 % topically induced timolol maleate eye drop.
Conclusion: After this study it is concluded that 0.5% topically induced timolol maleate eye drop lowers systemic blood pressure as well as heart rate also.
Methods: Total 60 patients were randomly selected and equally divided into group I (n=30) and group II (n=30). Group I – IOP between 20 to 30 mm Hg at Schiotz. Group II – IOP between 31 to 40 mm Hg at Schiotz. Each group was further divided into two subgroups, IB and IIB. Subgroup IB and IIB included those on timolol maleate (0.5% topical) administered one drop twice daily for 24 weeks. All 60 patients were evaluated for heart rate and blood pressure examination at the interval of 2nd, 4th, 6th, 8th, 10th, 12th, 14th, 16th, 18th, 20th and 24th weeks. Adverse effects of the drug during study period were also noted. Mean +- SD, t value, p value were analysed by graph pad software.
Results: A mean pre-treatment heart rate was 78.17 ± 3.12 beats / min and after at the end of 24 weeks of treatment there was a mean reduction of 4.0 ± 2.26 beats/min when 0.5% topical timolol maleate eye drop was induced. A mean pre-treatment systolic and diastolic blood pressure were 131.0±10.69 mm Hg and 85.86±5.69 mm Hg respectively. There was a fall of 5.0 ± 3.48 mm Hg of systolic blood pressure and 3.29±2.78 mm Hg of diastolic blood pressure at the end of 24 weeks after treatment with 0.5 % topically induced timolol maleate eye drop.
Conclusion: After this study it is concluded that 0.5% topically induced timolol maleate eye drop lowers systemic blood pressure as well as heart rate also.
References
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2. Mantravadi AV, Vadhar N. "Glaucoma". Primary Care 2015;42 (3):437-49.
3. Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, Pokharel GP, et al. "Global data on visual impairment in the year 2002". Bulletin of the World Health Organization 2004;82(11):844-51.
4. Schuman JS. Clinical experience with brimondine 0.2% and timolol 0.5% in glaucoma and ocular hypertension. Surv Ophthalmol 1996;41(Suppl 1):S27–37.
5. Fischer J, Ganellin CR. Analogue-based Drug Discovery. John Wiley & Sons 2006: p. 460.
6. Strohmaier K, Snyder E, Adamsons I. A multicenter study comparing dorzolamide and pilocarpine as adjunctive therapy to timolol: patient preference and impact on daily life". Journal of the American Optometric Association 1998;69 (7):441-51.
7. Strahlman E, Tipping R, Vogel R. A Double-Masked, Randomized 1-Year Study Comparing Dorzolamide (Trusopt), Timolol, and Betaxolol. Arch Ophthalmol 1995;113(8):1009-16.
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Dec 21, 2024
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Dr. Akash Chandra, Dr. Sanjeet Kumar, Dr. Gajendra Kumar Singh, & Dr. Bina Kumari. (2024). TO STUDY THE EFFECTS OF 0.5% TOPICAL TIMOLOL ON HEART RATE AND BLOOD PRESSURE IN PATIENTS SUFFERING FROM OPEN ANGLE GLAUCOMA-- A CROSS-SECTIONAL STUDY. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1597-1601. https://doi.org/10.53555/qffnwd79
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Author Biographies
Dr. Akash Chandra
Assistant Professor, Department of Pharmacology, Shaheed Nirmal Mahto Government Medical College, Dhanbad, Jharkhand, India.
Dr. Sanjeet Kumar
Senior Resident, Department of FMT, Shaheed Nirmal Mahto Government Medical College, Dhanbad, Jharkhand, India.
Dr. Gajendra Kumar Singh
Professor, Department of Pharmacology, MGM Medical College, Jamshedpur, Jharkhand, India.
Dr. Bina Kumari
Senior Lecturer, Department of Prosthodontics, Awadh Dental College, Jamshedpur, Jharkhand, India.
How to Cite
Dr. Akash Chandra, Dr. Sanjeet Kumar, Dr. Gajendra Kumar Singh, & Dr. Bina Kumari. (2024). TO STUDY THE EFFECTS OF 0.5% TOPICAL TIMOLOL ON HEART RATE AND BLOOD PRESSURE IN PATIENTS SUFFERING FROM OPEN ANGLE GLAUCOMA-- A CROSS-SECTIONAL STUDY. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1597-1601. https://doi.org/10.53555/qffnwd79