ASSOCIATION OF VITAMIN D SUPPLEMENTATION WITH ANTHROPOMETRIC, BIOCHEMICAL AND CLINICAL CHARACTERISTICS IN PCOS WOMEN
Main Article Content
Keywords
PCOS, Vitamin D Supplementation, Anthropometric Characteristics, Biochemical Values, Clinical Characteristics
Abstract
Suffering from health problems such as Polycystic Ovary Syndrome (PCOS) requires a great attention to the nutritional therapy. The women with PCOS undergo hormonal and metabolic changes, leading to various symptoms including irregular menstrual cycle, hirsutism, acne, baldness etc. Women with PCOS may also experience increased body weight and reduced serum Vitamin D levels which may even worsen the symptoms. Reduced vitamin D levels in body are considered to be link with increased insulin resistance and other symptoms. This study aims to find out the efficacy of vitamin D supplementation on PCOS symptoms with a focus on the anthropometric, biochemical and clinical characteristics in women with PCOS. Literature from 2018 to 2024 was searched using Pub Med, Google Scholar and Science Direct. As per the literature, studies show that even only 5% reduction in the body weight and improving the levels of vitamin D in the body can result in improved symptoms of PCOS including insulin resistance, fasting plasma glucose (FPG) levels, fasting blood insulin levels and menstrual cycle.
References
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10. L. Barrea, L. Verde, C. Vetrani, S. Savastano, A. Colao, and G. Muscogiuri, “Chronotype: A Tool to Screen Eating Habits in Polycystic Ovary Syndrome?,” Nutrients, vol. 14, no. 5, p. 955, Feb. 2022, doi: 10.3390/nu14050955.
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14. E. Y. Rad, S. Saboori, E. Falahi, and M. Djalali, “Vitamin D supplementation decreased body weight and body mass index of Iranian type-2 diabetic patients: A randomised clinical trial study”.
15. A. K. KIANI, K. DONATO, K. DHULI, L. STUPPIA, and M. BERTELLI, “Dietary supplements for polycystic ovary syndrome,” J Prev Med Hyg, vol. 63, no. 2 Suppl 3, pp. E206–E213, Oct. 2022, doi: 10.15167/2421-4248/jpmh2022.63.2S3.2762.
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17. F. Salehpour et al., “Transcranial Photobiomodulation Improves Cognitive Performance in Young Healthy Adults: A Systematic Review and Meta-Analysis,” Photobiomodul Photomed Laser Surg, vol. 37, no. 10, pp. 635–643, Oct. 2019, doi: 10.1089/photob.2019.4673.
18. M. Seyyed Abootorabi, P. Ayremlou, T. Behroozi-Lak, and S. Nourisaeidlou, “The effect of vitamin D supplementation on insulin resistance, visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome: a randomized placebo-controlled trial,” Gynecol Endocrinol, vol. 34, no. 6, pp. 489–494, Jun. 2018, doi: 10.1080/09513590.2017.1418311.
19. C.-Y. Miao, X.-J. Fang, Y. Chen, and Q. Zhang, “Effect of vitamin D supplementation on polycystic ovary syndrome: A meta-analysis,” Exp Ther Med, vol. 19, no. 4, pp. 2641–2649, Apr. 2020, doi: 10.3892/etm.2020.8525.
20. A. Bahadur, M. Naithani, L. Chawla, A. Yadav, R. Mundhra, and J. Chaturvedi, “Effect of Two Different Doses of Vitamin D Supplementation on Clinical, Metabolic, and Hormonal Profiles of Patients with Polycystic Ovary Syndrome (PCOS) with Insulin Resistance: A Randomized Controlled Trial,” Journal of South Asian Federation of Obstetrics and Gynaecology, vol. 14, no. 3, pp. 307–312, Jul. 2022, doi: 10.5005/jp-journals-10006-2052.
21. A. Ahmed et al., “A comprehensive review on the impact of calcium and vitamin D insufficiency and allied metabolic disorders in females,” Food Science & Nutrition, vol. 11, no. 9, pp. 5004–5027, 2023, doi: 10.1002/fsn3.3519.
22. A. Williams, J. R. Babu, D. D. Wadsworth, D. Burnett, and T. Geetha, “The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review,” Horm Metab Res, vol. 52, no. 7, pp. 485–491, Jul. 2020, doi: 10.1055/a-1160-9902.
23. J.-F. Zhao, B.-X. Li, and Q. Zhang, “Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome: a meta-analysis study,” Annals of Palliative Medicine, vol. 10, no. 1, pp. 16983–16183, Jan. 2021, doi: 10.21037/apm-20-2201.
24. N. Behmanesh, A. Abedelahi, H. N. Charoudeh, and A. Alihemmati, “Effects of vitamin D supplementation on follicular development, gonadotropins and sex hormone concentrations, and insulin resistance in induced polycystic ovary syndrome,” Turk J Obstet Gynecol, vol. 16, no. 3, pp. 143–150, Sep. 2019, doi: 10.4274/tjod.galenos.2019.46244.
25. S. Jafari-Sfidvajani, R. Ahangari, M. Hozoori, H. Mozaffari-Khosravi, H. Fallahzadeh, and A. Nadjarzadeh, “The effect of vitamin D supplementation in combination with low-calorie diet on anthropometric indices and androgen hormones in women with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial,” J Endocrinol Invest, vol. 41, no. 5, pp. 597–607, May 2018, doi: 10.1007/s40618-017-0785-9.
26. K. H. Serih et al., “Investigation the Relation Between Transforming Growth Factor-β1 Bioavailability with Vitamin D and Calcium in PCOS Patients. | Journal of Contemporary Medical Sciences | EBSCOhost.” Accessed: Apr. 28, 2024. [Online]. Available: https://openurl.ebsco.com/contentitem/doi:10.22317%2Fjcms.v9i6.1466?sid=ebsco:plink:crawler&id=ebsco:doi:10.22317%2Fjcms.v9i6.1466
27. N. Al-Bayyari, H. Al-Domi, F. Zayed, R. Hailat, and A. Eaton, “Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial,” Clinical Nutrition, vol. 40, no. 3, pp. 870–878, Mar. 2021, doi: 10.1016/j.clnu.2020.09.024.
28. Y. Han, Q. Cao, X. Qiao, and W. Huang, “Effect of vitamin D supplementation on hormones and menstrual cycle regularization in polycystic ovary syndrome women: A systemic review and meta-analysis,” Journal of Obstetrics and Gynaecology Research, vol. n/a, no. n/a, doi: 10.1111/jog.15727.
29. Z. S. Sert, S. A. Yılmaz, Ö. Seçilmiş, S. Abuşoğlu, A. Ünlü, and Ç. Çelik, “Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome,” Ir J Med Sci, vol. 191, no. 6, pp. 2657–2662, Dec. 2022, doi: 10.1007/s11845-021-02899-3.
2. S. Ashraf, M. Nabi, S. ul A. Rasool, F. Rashid, and S. Amin, “Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: a review,” Egypt J Med Hum Genet, vol. 20, no. 1, p. 25, Nov. 2019, doi: 10.1186/s43042-019-0031-4.
3. S. Singh et al., “Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics,” Journal of Clinical Medicine, vol. 12, no. 4, Art. no. 4, Jan. 2023, doi: 10.3390/jcm12041454.
4. S. Abraham Gnanadass, Y. Divakar Prabhu, and A. Valsala Gopalakrishnan, “Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update,” Arch Gynecol Obstet, vol. 303, no. 3, pp. 631–643, Mar. 2021, doi: 10.1007/s00404-020-05951-2.
5. X. Zeng, Y. Xie, Y. Liu, S. Long, and Z. Mo, “Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity,” Clinica Chimica Acta, vol. 502, pp. 214–221, Mar. 2020, doi: 10.1016/j.cca.2019.11.003.
6. E. Lerchbaum et al., “Effects of Vitamin D Supplementation on Surrogate Markers of Fertility in PCOS Women: A Randomized Controlled Trial,” Nutrients, vol. 13, no. 2, p. 547, Feb. 2021, doi: 10.3390/nu13020547.
7. A. Mohan et al., “Vitamin D and polycystic ovary syndrome (PCOS): a review,” Annals of Medicine and Surgery, vol. 85, no. 7, p. 3506, Jul. 2023, doi: 10.1097/MS9.0000000000000879.
8. S. Guo, R. Tal, H. Jiang, T. Yuan, and Y. Liu, “Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism,” Int J Endocrinol, vol. 2020, p. 7850816, 2020, doi: 10.1155/2020/7850816.
9. F. Gokosmanoglu, A. Onmez, and H. Ergenç, “The relationship between Vitamin D deficiency and polycystic ovary syndrome,” Afr Health Sci, vol. 20, no. 4, pp. 1880–1886, Dec. 2020, doi: 10.4314/ahs.v20i4.45.
10. L. Barrea, L. Verde, C. Vetrani, S. Savastano, A. Colao, and G. Muscogiuri, “Chronotype: A Tool to Screen Eating Habits in Polycystic Ovary Syndrome?,” Nutrients, vol. 14, no. 5, p. 955, Feb. 2022, doi: 10.3390/nu14050955.
11. Y. Li et al., “The correlation between vitamin D, glucose homeostasis and androgen level among polycystic ovary syndrome patients: a cross-sectional study,” Gynecological Endocrinology, vol. 37, no. 3, pp. 235–239, Mar. 2021, doi: 10.1080/09513590.2020.1810228.
12. S. Simpson, L. Pal, and D. B. Seifer, “Emerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS,” in Polycystic Ovary Syndrome: Current and Emerging Concepts, L. Pal and D. B. Seifer, Eds., Cham: Springer International Publishing, 2022, pp. 489–509. doi: 10.1007/978-3-030-92589-5_24.
13. J. Mesinovic et al., “The Relationship between Vitamin D Metabolites and Androgens in Women with Polycystic Ovary Syndrome,” Nutrients, vol. 12, no. 5, Art. no. 5, May 2020, doi: 10.3390/nu12051219.
14. E. Y. Rad, S. Saboori, E. Falahi, and M. Djalali, “Vitamin D supplementation decreased body weight and body mass index of Iranian type-2 diabetic patients: A randomised clinical trial study”.
15. A. K. KIANI, K. DONATO, K. DHULI, L. STUPPIA, and M. BERTELLI, “Dietary supplements for polycystic ovary syndrome,” J Prev Med Hyg, vol. 63, no. 2 Suppl 3, pp. E206–E213, Oct. 2022, doi: 10.15167/2421-4248/jpmh2022.63.2S3.2762.
16. Y. Mu, D. Cheng, T. Yin, and J. Yang, “Vitamin D and Polycystic Ovary Syndrome: a Narrative Review,” Reprod. Sci., vol. 28, no. 8, pp. 2110–2117, Aug. 2021, doi: 10.1007/s43032-020-00369-2.
17. F. Salehpour et al., “Transcranial Photobiomodulation Improves Cognitive Performance in Young Healthy Adults: A Systematic Review and Meta-Analysis,” Photobiomodul Photomed Laser Surg, vol. 37, no. 10, pp. 635–643, Oct. 2019, doi: 10.1089/photob.2019.4673.
18. M. Seyyed Abootorabi, P. Ayremlou, T. Behroozi-Lak, and S. Nourisaeidlou, “The effect of vitamin D supplementation on insulin resistance, visceral fat and adiponectin in vitamin D deficient women with polycystic ovary syndrome: a randomized placebo-controlled trial,” Gynecol Endocrinol, vol. 34, no. 6, pp. 489–494, Jun. 2018, doi: 10.1080/09513590.2017.1418311.
19. C.-Y. Miao, X.-J. Fang, Y. Chen, and Q. Zhang, “Effect of vitamin D supplementation on polycystic ovary syndrome: A meta-analysis,” Exp Ther Med, vol. 19, no. 4, pp. 2641–2649, Apr. 2020, doi: 10.3892/etm.2020.8525.
20. A. Bahadur, M. Naithani, L. Chawla, A. Yadav, R. Mundhra, and J. Chaturvedi, “Effect of Two Different Doses of Vitamin D Supplementation on Clinical, Metabolic, and Hormonal Profiles of Patients with Polycystic Ovary Syndrome (PCOS) with Insulin Resistance: A Randomized Controlled Trial,” Journal of South Asian Federation of Obstetrics and Gynaecology, vol. 14, no. 3, pp. 307–312, Jul. 2022, doi: 10.5005/jp-journals-10006-2052.
21. A. Ahmed et al., “A comprehensive review on the impact of calcium and vitamin D insufficiency and allied metabolic disorders in females,” Food Science & Nutrition, vol. 11, no. 9, pp. 5004–5027, 2023, doi: 10.1002/fsn3.3519.
22. A. Williams, J. R. Babu, D. D. Wadsworth, D. Burnett, and T. Geetha, “The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review,” Horm Metab Res, vol. 52, no. 7, pp. 485–491, Jul. 2020, doi: 10.1055/a-1160-9902.
23. J.-F. Zhao, B.-X. Li, and Q. Zhang, “Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome: a meta-analysis study,” Annals of Palliative Medicine, vol. 10, no. 1, pp. 16983–16183, Jan. 2021, doi: 10.21037/apm-20-2201.
24. N. Behmanesh, A. Abedelahi, H. N. Charoudeh, and A. Alihemmati, “Effects of vitamin D supplementation on follicular development, gonadotropins and sex hormone concentrations, and insulin resistance in induced polycystic ovary syndrome,” Turk J Obstet Gynecol, vol. 16, no. 3, pp. 143–150, Sep. 2019, doi: 10.4274/tjod.galenos.2019.46244.
25. S. Jafari-Sfidvajani, R. Ahangari, M. Hozoori, H. Mozaffari-Khosravi, H. Fallahzadeh, and A. Nadjarzadeh, “The effect of vitamin D supplementation in combination with low-calorie diet on anthropometric indices and androgen hormones in women with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial,” J Endocrinol Invest, vol. 41, no. 5, pp. 597–607, May 2018, doi: 10.1007/s40618-017-0785-9.
26. K. H. Serih et al., “Investigation the Relation Between Transforming Growth Factor-β1 Bioavailability with Vitamin D and Calcium in PCOS Patients. | Journal of Contemporary Medical Sciences | EBSCOhost.” Accessed: Apr. 28, 2024. [Online]. Available: https://openurl.ebsco.com/contentitem/doi:10.22317%2Fjcms.v9i6.1466?sid=ebsco:plink:crawler&id=ebsco:doi:10.22317%2Fjcms.v9i6.1466
27. N. Al-Bayyari, H. Al-Domi, F. Zayed, R. Hailat, and A. Eaton, “Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial,” Clinical Nutrition, vol. 40, no. 3, pp. 870–878, Mar. 2021, doi: 10.1016/j.clnu.2020.09.024.
28. Y. Han, Q. Cao, X. Qiao, and W. Huang, “Effect of vitamin D supplementation on hormones and menstrual cycle regularization in polycystic ovary syndrome women: A systemic review and meta-analysis,” Journal of Obstetrics and Gynaecology Research, vol. n/a, no. n/a, doi: 10.1111/jog.15727.
29. Z. S. Sert, S. A. Yılmaz, Ö. Seçilmiş, S. Abuşoğlu, A. Ünlü, and Ç. Çelik, “Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome,” Ir J Med Sci, vol. 191, no. 6, pp. 2657–2662, Dec. 2022, doi: 10.1007/s11845-021-02899-3.
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Dec 21, 2024
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How to Cite
Fatima Amjad, Izba Asif, Madiha Ghazanfar, Maimoona Waheed, Zoha Imtiaz, Nabila Iftikhar, Shahzadi Uzma Khan, Asma Sohail, & Haseeb Ahmed. (2024). ASSOCIATION OF VITAMIN D SUPPLEMENTATION WITH ANTHROPOMETRIC, BIOCHEMICAL AND CLINICAL CHARACTERISTICS IN PCOS WOMEN. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1586-1593. https://doi.org/10.53555/wea9r963
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Author Biographies
Fatima Amjad
Riphah International University, Islamabad Pakistan
Izba Asif
IBADAT International University, Islamabad Pakistan
Madiha Ghazanfar
IBADAT International University, Islamabad Pakistan
Maimoona Waheed
IBADAT International University, Islamabad Pakistan
Zoha Imtiaz
National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Nabila Iftikhar
IBADAT International University, Islamabad Pakistan
Shahzadi Uzma Khan
Institute of Food and Nutritional Sciences, PMAS Arid Agriculture University, Rawalpindi Pakistan
Asma Sohail
Institute of Food and Nutritional Sciences, PMAS Arid Agriculture University, Rawalpindi Pakistan
Haseeb Ahmed
IBADAT International University, Islamabad Pakistan
How to Cite
Fatima Amjad, Izba Asif, Madiha Ghazanfar, Maimoona Waheed, Zoha Imtiaz, Nabila Iftikhar, Shahzadi Uzma Khan, Asma Sohail, & Haseeb Ahmed. (2024). ASSOCIATION OF VITAMIN D SUPPLEMENTATION WITH ANTHROPOMETRIC, BIOCHEMICAL AND CLINICAL CHARACTERISTICS IN PCOS WOMEN. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1586-1593. https://doi.org/10.53555/wea9r963