PHARMACOLOGICAL ASSESSMENT OF ANTI-MAMMARY CARCINOMA ACTIVITY OF ANETHUM GRAVEOLENS SEEDS AND SPINACIA OLERACEA LEAVES.
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Keywords
Mammary carcinoma, Anethum graveolens, Spinacia oleracea, Anti-cancer, Polyherbal.
Abstract
Background: Breast cancer is the most commonly diagnosed malignancy in women and a leading cause of cancer-related mortality worldwide. Despite advancements in diagnostic and therapeutic strategies, breast cancer remains a significant clinical challenge due to its heterogeneity and the adverse effects of conventional treatments. The use of traditional herbal medicine, known for its minimal side effects and efficacy, offers a promising alternative.
Material & Methods: Aerial parts of Anethum graveolens seeds and Spinacia oleracea leaves were extracted using the Soxhlet extraction method. This study investigates the anti-mammary carcinoma potential of Anethum graveolens (dill) seeds and Spinacia oleracea (spinach) leaves, known for their bioactive compounds with anti-cancer properties.
Result & Discussion: At the different doses (10 to 100 µg/ml) of polyherbal extracts carried out for anticancer activity against MCF-7 cell line., the polyherbal extracts showed good activity against breast cancer cell line when compared with the standard drug 5 FU. These findings highlight the anti-cancer potential of polyherbal extract of Anethum graveolens seeds and Spinacia oleracea leaves as natural therapeutic agents for the management of mammary carcinoma.
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Ms. Sonawane R.R.
Research Scholar, Department of Pharmacology, Matoshri College of Pharmacy, Eklahare, Nashik
Ms. Suryavanshi P.S.
Research Scholar, Department of Pharmacology, Matoshri College of Pharmacy,
Eklahare, Nashik
Ms. Somvanshi S.R.
Research Scholar, Department of Pharmacology, Matoshri College of Pharmacy,
Eklahare, Nashik
Dr. Kapse S.N.
Associate Professor, Department of Pharmaceutical chemistry, Matoshri College of Pharmacy, Eklahare, Nashik
Mr. Patil R. N.
Assistant Professor, Department of Pharmacology, MET’s Institute of D.Pharmacy,
Adgaon, Nashik
Mr. Raut H.V.
Assistant Professor, Department of Pharmacology, MET’s Institute of D.Pharmacy,
Adgaon, Nashik