BLACK SEED OIL: A PROMISING ANTI-INFLAMMATORY AND ANTIOXIDANT AGENT
Main Article Content
Keywords
Black seeds, Nigella sativa, Thymoquinone, Anti-inflammatory, Antioxidant, Black seed oil
Abstract
Black seed oil, commonly known as Kalonji seed oil, has been used for centuries in traditional medicine for its therapeutic benefits. This review article aims to summarize the current state of knowledge on the pharmacological properties, formulations, and safety aspects of Black Seed Oil. The oil's bioactive compound, particularly thymoquinone shows Anti-inflammatory effects with potential application in treating arthritis, asthma, and allergies. It also shows Antioxidant properties by reducing oxidative stress and cell damage. It is also used to treat certain type of cancer, diabetes and microbial infection, various formulations, including emulsions, capsules, and topical preparations are made which Kalonji seed oil. Overall Black seed oil offers a range of health benefits with minimal side effects.
References
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8. Tembhurne SV, Feroz S, More BH, Sakarkar DM. A review on therapeutic potential of Nigella sativa (kalonji) seeds. J Med Plants Res. 2014 Jan 17;8(3):167-77
9. Kokoska L, Havlik J, Valterova I, Sovova H, Sajfrtova M, Jankovska I. Comparison of chemical composition and antibacterial activity of Nigella sativa seed essential oils obtained by different extraction methods. Journal of food protection. 2008 Dec 1;71(12):2475-80.
10. Mazaheri Y, Torbati M, Azadmard-Damirchi S, Savage GP. A comprehensive review of the physicochemical, quality and nutritional properties of Nigella sativa oil. Food reviews international. 2019 May 19;35(4):342-62.
11. Mazaheri Y, Torbati M, Azadmard-Damirchi S, Savage GP. A comprehensive review of the physicochemical, quality and nutritional properties of Nigella sativa oil. Food reviews international. 2019 May 19;35(4):342-62.
12. Kluwer WC. The review of natural products by facts and comparisons. St Louis, MO: Facts & Comparisons. 1999.
13. Aqel M, Shaheen R. Effects of the volatile oil of Nigella sativa seeds on the uterine smooth muscle of rat and guinea pig. Journal of ethnopharmacology. 1996 May 1;52(1):23-6.
14. Zedlitz S, Kaufmann R, Boehncke WH. Allergic contact dermatitis from black cumin (Nigella sativa) oil-containing ointment.
15. Steinmann A, Schätzle M, Agathos M, Breit R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatitis (01051873). 1997 May 1;36(5).
16. Akhondian1ABCDEF J, Parsa2ABCDE A, Rakhshande2BG H. The effect of Nigella sativa L.(black cumin seed) on intractable pediatric seizures. Med Sci Monit. 2007;13(12):559.
17. Zaoui A, Cherrah Y, Mahassini N, Alaoui K, Amarouch H, Hassar M. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine. 2002 Jan 1;9(1):69-74.
18. Arif S. Biological Evaluation and Comparison of Nigella sativa (Kalonji) and Trachyspermum ammi (Ajwain). Capital University. 2019..
19. Kruk I, Michalska T, Lichszteld K, Kładna A, Aboul-Enein HY. The effect of thymol and its derivatives on reactions generating reactive oxygen species. Chemosphere. 2000 Oct 1;41(7):1059-64.
20. Badary OA, Taha RA, Gamal El-Din AM, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scavenger. Drug and chemical toxicology. 2003 Jan 1;26(2):87-98.
21. Daba MH, Abdel-Rahman MS. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicology letters. 1998 Mar 16;95(1):23-9.
22. Yildiz F, Coban S, Terzi A, Ates M, Aksoy N, Cakir H, Ocak AR, Bitiren M. Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver. World journal of gastroenterology: WJG. 2008 Sep 9;14(33):5204.
23. Farah IO, Begum RA. Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Biomedical Sciences Instrumentation. 2003 Jan 1;39:359-64.
24. Salomi MJ, Nair SC, Panikkar KR. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice.
25. Mohamed AM, El-Sharkawy FZ, Ahmed SA, Aziz WM, Badary OA. Glycemic control and therapeutic effect of Nigella sativa and Curcuma longa on rats with streptozotocin-induced diabetic hepatopathy.
26. Salem ML, Hossain MS. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. International journal of immunopharmacology. 2000 Sep 1;22(9):729-40.
27. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta medica. 1995 Feb;61(01):33-6.
28. Akhtar AH, Ahmad KD, Gilani SN, Nazir A. Antiulcer effects of aqueous extracts of Nigella sativa and Pongamia pinnata in rats.
29. Jufri M, Namirah JI, Suryadi H. Formulation and stability study of black cumin (Nigella sativa L.) seed oil emulsion using sucrose palmitate as emulsifier. Int J App Pharm. 2022 Sep 1;14(05):113-8.
30. Bhor RJ, Sable KS, Bhosale MS, Dighe SB. Synthesis and Anti Convulsant Activity of" N'-{4-[2-(1h-Benzimidazol-2-Yl)-2-Oxoethyl] Phenyl}-2-Hydroxyacetohydrazide and Its Derivatives.
31. Mane SL, Chandakavthe BN, Atkare A, Kshirsagar A, Waykule N. FORMULATION AND EVALUATION OF HAND WASH GEL USING BLACK SEED OIL.
2. Butt MS, Sultan MT. Nigella sativa: reduces the risk of various maladies. Critical reviews in food science and nutrition. 2010 Jul 30;50(7):654-65.
3. Ismail MY, Yaheya M. Therapeutic role of prophetic medicine Habbat El Baraka (Nigella sativa L.)-A review. World Appl Sci J. 2009;7(9):1203-8.
4. Gilani AU, Jabeen Q, Khan MA. A review of medicinal uses and pharmacological activities of Nigella sativa. Pak J Biol Sci. 2004 Mar 15;7(4):441-51.
5. Flores JV, Kerna NA, Pruitt KD, Carsrud ND, Holets HM, Chawla S, Ngwu DC, Taha WT, Anderson II. J, Afolayan AY, Nnake I. Exploring the Therapeutic Potential of Plant Seeds: Health Benefits, Bioactive Compounds, Applications for Specific Medical Conditions, and Regulatory Challenges”. EC Nutrition. 2024; 19:01-17.
6. Thakur S, Kaurav H, Chaudhary G. Nigella sativa (Kalonji): A black seed of miracle. International Journal of Research and Review. 2021;8(4):342-57.
7. Sultana S, Asif HM, Akhtar N, Iqbal A, Nazar H, Rehman RU. Nigella sativa: monograph. Journal of Pharmacognosy and Phytochemistry. 2015;4(4):103-6.
8. Tembhurne SV, Feroz S, More BH, Sakarkar DM. A review on therapeutic potential of Nigella sativa (kalonji) seeds. J Med Plants Res. 2014 Jan 17;8(3):167-77
9. Kokoska L, Havlik J, Valterova I, Sovova H, Sajfrtova M, Jankovska I. Comparison of chemical composition and antibacterial activity of Nigella sativa seed essential oils obtained by different extraction methods. Journal of food protection. 2008 Dec 1;71(12):2475-80.
10. Mazaheri Y, Torbati M, Azadmard-Damirchi S, Savage GP. A comprehensive review of the physicochemical, quality and nutritional properties of Nigella sativa oil. Food reviews international. 2019 May 19;35(4):342-62.
11. Mazaheri Y, Torbati M, Azadmard-Damirchi S, Savage GP. A comprehensive review of the physicochemical, quality and nutritional properties of Nigella sativa oil. Food reviews international. 2019 May 19;35(4):342-62.
12. Kluwer WC. The review of natural products by facts and comparisons. St Louis, MO: Facts & Comparisons. 1999.
13. Aqel M, Shaheen R. Effects of the volatile oil of Nigella sativa seeds on the uterine smooth muscle of rat and guinea pig. Journal of ethnopharmacology. 1996 May 1;52(1):23-6.
14. Zedlitz S, Kaufmann R, Boehncke WH. Allergic contact dermatitis from black cumin (Nigella sativa) oil-containing ointment.
15. Steinmann A, Schätzle M, Agathos M, Breit R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatitis (01051873). 1997 May 1;36(5).
16. Akhondian1ABCDEF J, Parsa2ABCDE A, Rakhshande2BG H. The effect of Nigella sativa L.(black cumin seed) on intractable pediatric seizures. Med Sci Monit. 2007;13(12):559.
17. Zaoui A, Cherrah Y, Mahassini N, Alaoui K, Amarouch H, Hassar M. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine. 2002 Jan 1;9(1):69-74.
18. Arif S. Biological Evaluation and Comparison of Nigella sativa (Kalonji) and Trachyspermum ammi (Ajwain). Capital University. 2019..
19. Kruk I, Michalska T, Lichszteld K, Kładna A, Aboul-Enein HY. The effect of thymol and its derivatives on reactions generating reactive oxygen species. Chemosphere. 2000 Oct 1;41(7):1059-64.
20. Badary OA, Taha RA, Gamal El-Din AM, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scavenger. Drug and chemical toxicology. 2003 Jan 1;26(2):87-98.
21. Daba MH, Abdel-Rahman MS. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicology letters. 1998 Mar 16;95(1):23-9.
22. Yildiz F, Coban S, Terzi A, Ates M, Aksoy N, Cakir H, Ocak AR, Bitiren M. Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver. World journal of gastroenterology: WJG. 2008 Sep 9;14(33):5204.
23. Farah IO, Begum RA. Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Biomedical Sciences Instrumentation. 2003 Jan 1;39:359-64.
24. Salomi MJ, Nair SC, Panikkar KR. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice.
25. Mohamed AM, El-Sharkawy FZ, Ahmed SA, Aziz WM, Badary OA. Glycemic control and therapeutic effect of Nigella sativa and Curcuma longa on rats with streptozotocin-induced diabetic hepatopathy.
26. Salem ML, Hossain MS. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. International journal of immunopharmacology. 2000 Sep 1;22(9):729-40.
27. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta medica. 1995 Feb;61(01):33-6.
28. Akhtar AH, Ahmad KD, Gilani SN, Nazir A. Antiulcer effects of aqueous extracts of Nigella sativa and Pongamia pinnata in rats.
29. Jufri M, Namirah JI, Suryadi H. Formulation and stability study of black cumin (Nigella sativa L.) seed oil emulsion using sucrose palmitate as emulsifier. Int J App Pharm. 2022 Sep 1;14(05):113-8.
30. Bhor RJ, Sable KS, Bhosale MS, Dighe SB. Synthesis and Anti Convulsant Activity of" N'-{4-[2-(1h-Benzimidazol-2-Yl)-2-Oxoethyl] Phenyl}-2-Hydroxyacetohydrazide and Its Derivatives.
31. Mane SL, Chandakavthe BN, Atkare A, Kshirsagar A, Waykule N. FORMULATION AND EVALUATION OF HAND WASH GEL USING BLACK SEED OIL.
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Published
Dec 11, 2024
Article Details
How to Cite
Bhavesh Prajapati, Dr. Nikita Patel, & Dr. Pragnesh Patani. (2024). BLACK SEED OIL: A PROMISING ANTI-INFLAMMATORY AND ANTIOXIDANT AGENT. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1151-1156. https://doi.org/10.53555/ew5jx165
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Author Biographies
Bhavesh Prajapati
Khyati College of Pharmacy, Palodia, Ahmedabad,
Dr. Nikita Patel
Associate Professor, Department of Pharmaceutics, Khyati College of Pharmacy, Palodia, Ahmadabad
Dr. Pragnesh Patani
Principal, Khyati College of Pharmacy, Palodia, Ahmedabad
How to Cite
Bhavesh Prajapati, Dr. Nikita Patel, & Dr. Pragnesh Patani. (2024). BLACK SEED OIL: A PROMISING ANTI-INFLAMMATORY AND ANTIOXIDANT AGENT. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1151-1156. https://doi.org/10.53555/ew5jx165