EXPLORING THE MULTIFACETED BENEFITS OF TERMINALIA CHEBULA: AN IN-DEPTH REVIEW
Main Article Content
Keywords
Terminalia chebula, Phytoconstituents, Biological and Pharmacological conditioning, Clinical studies, Medicinal uses, Safety evaluation
Abstract
In traditional Ayurvedic medicine, Terminalia chebula, also referred to as Haritaki, is a well-known medicinal herb. With a focus on its possible uses in contemporary health and wellness contexts, this abstract examines the many health advantages ascribed to Terminalia chebula. The plant's pharmacological qualities, such as its antibacterial, anti-inflammatory, antioxidant, and anticancer effects, are summarized in this study based on current research. Further investigation is done into the effects of Terminalia chebula on cardiovascular health, metabolic diseases, and gastrointestinal health. The plant's promise as a versatile medicinal agent is highlighted in this abstract, which also emphasizes the need for more research to fully clarify its clinical applications and mechanisms of action. Traditional knowledge is integrated with modern scientific results.
References
2. Agarwal M, Sharma P, Kushwaha S. “Antifertility efficacy of 50% ethanolic extract of Calendula officinalis in male rats.” Int J Pharmacy Pharmaceutical Sci 2011;3(5):192-196.
3. Gupta PC. “Withania coagulans Dunal- An Overview.” Int J Pharmaceutical Sci Review Research 2012;12(2):68-71.
4. Naik GH, Priyadarsini KI, Naik DB, Gangabhagirathi R, Mohan H. “Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and a probable radioprotector.” Phytomedicine 2004;11:530-38.
5. Aneja KR, Joshi R. “Evaluation of antimicrobial properties of fruit extracts of Terminalia chebula against dental caries pathogens.” Jundishapur J Microbiol 2009;2(3):105-11.
6. Ayyanara M, Ignacimuthu S. “Ethnobotanical survey of medicinal plants commonly used by Kani tribals in Tirunelveli hills of Western Ghats in India.” J Ethnopharmacol 2011;134:851-64
7. Kumar KJ. “Effect of geographical variation on contents of tannic acid, gallic acid, chebulinic acid and ethyl gallate in Terminalia chebula. Natural Products.” 2006;2(3-4):170-75.
8. Juang LJ, Sheu SJ, Lin 11. TC. “Determination of hydrolyzable tannins in the fruit of Terminalia chebula Retz. by high-performance liquid chromatography and capillary electrophoresis.” J Sep Sci 2004;27(9):718–24.
9. Srivastava A, Chandra A, Singh M, Jamal F, Rastogi P, Rajendran SM, Bansode FW, Lakshmi V. “Inhibition of hyaluronidase activity of human and rat spermatozoa in vitro and antispermatogenic activity in rats in vivo by Terminalia chebula, a flavonoid rich plant.” Reproductive Toxicol 2010;29:214–24.
10. Kundu AP, Mahato SB. “Triterpenoids and their glycosides from 13. Terminalia chebula. Phytochemistry” 1993 ;32(4):999- 1002.
11. Saleem A, Husheem M, Harkonen P, Pihlaja K. “Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula Retz. Fruit.” J Ethnopharmacol 2002;81:327- 36.
12. Kaur S, Michael H, Arora S, Harkonen PL, Kumar S. “The in vitro cytotoxic and apoptotic activity of Triphala-an Indian herbal drug.” J Ethnopharmacol 2005;97:15–20.
13. Rathinamoorthy, R., and G. Thilagavathi. "Terminalia chebula-review on pharmacological and biochemical studies." International Journal of PharmTech Research 2014 6.1: 97-116.
14. Panunto W, Jaijoy K, Lerdvuthisopon N, Lertprasertsuke N, Jiruntanat N, Soonthornchareonnon N, Sireeratawong S. “Acute and chronic toxicity studies of the water extract from dried fruits of Terminalia chebula Rezt. in rats.” Int J Applied Research in Natural Products 2011;3(4):36-43.
15. Prasad L, Khan TH, Jahangir T, Sultana S. “Chemomodulatory effects of Terminalia chebula against nickel chloride induced oxidative stress and tumor promotion response in male Wistar rats.” J Trace Elements in Medicine and Biology 2006;20:233– 39.
16. Kaur S, Michael H, Arora S, Harkonen PL, Kumar S. “The in vitro cytotoxic and apoptotic activity of Triphala-an Indian herbal drug.” J Ethnopharmacol 2005;97:15–20.
17. Usha C, Satyanarayanan R and Velmurugan A. “Use of an aqueous extract of Terminalia chebula as an anticaries agent: A clinical study.” Indian J Dent Res 2007;18(4):152-56.
18. Kirtikar KR, Basu BD. “Terminalia chebula In: Indian Medicinal Plants,” 2nd eds, Allahabad, India: Lolit Mohan Basu Pub 1935.p. 1020-23.
19. Kim JH, Koo YC, Hong CO, Yang SY, Jun W, Lee KW. “Mutagenicity and oral toxicity studies of Terminalia chebula.” Phytotherapy Res 2011 May 2 [Epub ahead of print].
20. Sato Y, Oketani H, Singyouchi K, Ohtsubo T, Kihara M, Shibata H and Higuti T. “Extraction and purification of effective antimicrobial constituents of Terminalia chebula Retz. against methicillin-resistant Staphylococcus aureus.” Bio Pharm Bull 1997;20(4): 401-04.
21. Ahmad I, Mehmood Z, Mohammad F. “Screening of some Indian medicinal plants for their antimicrobial properties.” J Ethnopharmacol 1998;62:183-93.
22. Malekzadeh F, Ehsanifar H, Shahamat M, Levin M, Colwell RR. “Antibacterial activity of black myrobalan (Terminalia chebula Retz) against Helicobacter pylori.” J Antimicrobial Agents 2001;18:85–88.
23. Kim HG, Cho JH, Jeong EY, Lim JH, Lee SH, Lee HS. “Growthinhibiting activity of active component isolated from Terminalia chebula fruits against intestinal bacteria.” J Food Prot .2006;69(9):2205-9.
24. Kannan P, Ramadevi SR, Hopper W. “Antibacterial activity of Terminalia chebula fruit extract.” African J Microbiol Res 2009;3(4):180-84.
25. Dutta BK, Rahman I, Das TK. “Antifungal activity of Indian plant extracts.” Mycoses 1998;41(11-12):535-36.
26. Mehmood Z, Ahmad I, Mohammad F, Ahmad S. “Indian medicinal plants: A potential source for anticandidal drugs.” Pharmaceutical Biology 1999;37(3):237–42.
27. Vonshak O, Barazani P, Sathiyomoorthy R, Shalev D, Vardy A Golan-goldhirsh. “Screening of South-Indian medicinal plants for antifungal activity.” Phytotherapy Res 2003;17(9):1123-25.
28. Sohni YR, Bhatt RM. “Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies.” J Ethnopharmacol 1996;54(2-3): 119-24.
29. Sohni YR, Kaimal P, Bhatt RM. “The antiamoebic effect of a crude drug formulation of herbal extracts against Entamoeba histolytica in vitro and in vivo.” J Ethnopharmacol 1995;45(1): 43-52.
30. A.H.N. Jeong, C.Y. Kim, J.S. Lee, T.G. Kim, S.H. Kim, C.K. Lee, B. Lee, C.G. Shim, H. Hoon, J. Kim. “Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flovonol glycoside gallates from Euphorbia pekinensis.” Planta Medica. 2002 68 : 457-9.
31. Suthienkul et al. “Retroviral reverse transcriptase inhibitory activity in Thai Herbs and Species. Screening with moloney murine leukemia viral enzyme.” South-East Asian Journal Trop. Med., Public Health. 1993 24 (4) : 751-5.
32. V. Badmaev, M. Nowakowski. “Protection of epithelial cells against influenza A virus by plant derived biological response modifier Ledretan-96.” Phytother. Res., 2000 44(4) : 245-9.
33. S. Kaur, I.S. Grover, M. Singh, S. Kaur. “Antimutagenesity of hydrolyzable tannins from Terminalia chebula in Salmonella typhimerium.” Mutagen Res., 1998 419(1-3) : 169- 79.
34. Saleem, M. Hushum, P. Harkonen, K. Pihlaja. “Inhibition of cancer cell growth by crude extract and phenolics of Terminalia chebula fruit.” J. Ethnopharmacol., 2002 81: 327- 36.
35. S. Arora, K. Kaw, S. Kaur. “Indian Medicinal Plants as reserver of protective phytochemicals. Tetragenesis, Carcinogenesis and Mutagenesis”, 2003 23(1) :295-300.
36. H. Y. Cheng, T.C. Lin, K.H. Yu, C.M. Yang, C.C. Lin. “Antioxidant and free radical scavenging activities of Terminalia chebula.” Biol. Pharm.Bull. 2003 26(9) :1331-5.
37. G.H. Naik, K.I. Priyadarshini, D.B. Naik, R. Gangabhagirathi, H. Mohan. “Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and the probable radioprotector.” Phytomedicine, 2004 11 (6) : 530-8.
38. H.S. Lee, N.H. Won, K.H. Kim, H. Lee, W. Jun, K.W. Lee. “Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro.” Biol. Pharm. Bull. 2005 28(9) : 1639-44.
39. S.S. Tasduq, A.K. Singh, N.K. Salti, D.K. Gupta, K. Suri. “Terminalia chebula fruits prevent liver toxicity caused by sub-chronic adminstration of refampicin, isoniazid and pyrazinamide (PZA) in combination.” Human and Exp. Toxicol. 2006 25(3) : 11-18.
40. N.M. Gandhi, C.K.K. Nayar. “Radiation protection by Terminalia chebula some mechanistic aspects.” Molecular and Cellular Biochemistry. 2005 277(1-2) : 43-8.
41. N.K. Rao, N. Srinavas. “Antidiabetic and retinoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats.” BMC Complement Altern. Med. 2006 6 : 127-32.
42. M.C. Sabu, R. Kuttan. “Antidiabetic activity of medicinal plants and its relationship with their antioxidant properties.” J. Ethnopharmacol. 2002 81 : 155-60.
43. S.K. Candhipuram Perasamy, A. Palanisams, S.K. Durairaj, P.S. Sovimuthu. “Antidiabetic activity of Terminalia chebula on streptozotocin-induced diabetic rats.” J. Health Sci., 2006 52(3) : 283-91.
44. L. Sugana, S. Singh, P. Shivakumar, P. Sampath, G. Chandrakasan. “Influence of Terminalia chebula on dermal wound healing in rats.” Phytother Res., 2002 16(3) : 227-31.
45. N.N. Rege, U.M. Thatte, S.A. Dahanukar. “Adaptogenic properties of six Rasayana Hebrs used in Ayurvedic medicines.” Phytotherapy Res. 1999 13 : 275-91.
46. T.Y. Shin, H.G. Jeong, D.K. kim, S.H. Kim, J.K. Lee, B.S. Chae, J.H. Kim, H.W. kong, C.M. Lee, K.C. Lee, S.T. Park, E.J. Lee, J.P. Lin, H.M. Kim,Y.M. Lee. “Inhibitory action of water soluble fraction of Terminalia chebula on systematic and local anaphylaxis.” J. Ethnopharmacol. 2001 74 : 133-40.
47. M.D. Tamhane, S.P. Thorate, N.N. Rege, S.A. Dahanukar. “Effect of oral adnministration of Terminalia chebula on gastric emptying : An experimental study.” J. Postgrad. Med., 1997 43 (1) : 12-13.
48. T.S. Nadar, M.M. Pillai.” Effect of Ayurvedic medicines on beta-glucuronidase activity of Brunner’s glands during recovery from cysteamine-induced duodenal ulcers in rats.” Indian J. Exp. Biol. 1989 27(11) : 959-62.
49. V.N. Tripathi, S.K. Tiwari, J.P. Gupta, G.N. Chaturvedi. “Clinical trials of Haritaki in treatment of simple constipation.” Sachitra Ayur. 1999 35(11) : 733-40.
50. A.G. Jagpat, S.G. Karkera. “Potential of the aqueous extract of Terminalia chebula as an anticaries agent.” J. Ethnopharmacol. 1999 68(1-3) : 299-06 .