A BRIEF REVIEW ON PHARMACOLOGICAL BENEFITS OF VERBASCUM THAPSUS L
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Keywords
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Abstract
Verbascum Thapsus L., often known as common mullein, is a medicinal plant that is easily located along roadsides, in meadows, and on grazing grounds. It has been used to treat a variety of conditions, including asthma, inflammatory disorders, lung issues, diarrhea, and migraine, headaches. Common mullein has been used medicinally since ancient times, but in recent years, its popularity has grown economically. A growing body of research investigations has been conducted in support of the use of common mullein extracts in folk medicine in recent times. Detailed review and its pharmacological actions are highlighted in this article which can be one of the promising herbs for the treatment of variety of disorders related to inflammatory and allergic conditions.
References
1. Yasser M. Okasha, Fify I. Fathy, Fathy M. Soliman, Nesrin M. Fayek; “The Untargeted Phytochemical Profile of Verbascum thapsus L. with Potent Antiviral, Antibacterial and Anticancer Activities”.2023,156,334-341.
2. Blanco-Salas J, Hortigón-Vinagre MP, Morales-Jadán D, Ruiz-Téllez T; “A Review on the Case of Mullein (Verbascum, Scrophulariaceae).” 2021,10(7), 618.
3. Arzu Uçar Turker & Gurel Ekrem; “Common Mullein (Verbascum Thapsus L.): Recent Advances in Research”. Phytotherapy Research, 2005,19(9) 733– 739.
4. N.D Camper & Arzu Ucar Turker; “Biological Activity of Common Mullein, A Medicinal Plant”. The Journal of Ethnopharmacology, 2002,8(2), 117-125.
5. Mayank A. Panchal, Krishna Murti, Vijay Lambole, “Pharmacological Properties of Verbascum Thapsus-A Review”. International Journal of Pharmaceutical Sciences Review and Research, 2010, 5(2), 73-77.
6. Ahmed, M., & Fatima, M.; “Anti-inflammatory and Antioxidant Activity of Verbascum Thapsus L. (Scrophulariaceae).” Journal of Ethnopharmacology, 2016,182.
7. Zhang, Y., Wang, P.; “Histological Examination of the Lung Protective Effects of Verbascum Thapsus Extract in a Murine Model.” 2018, 33(4), 435-442.
8. Martínez, M., & Espinosa; “Therapeutic Potential of Verbascum Thapsus in Traditional and Modern Medicine”. Phytomedicine, 2019, 60, 152.
9. Rachelle Karman, “Assessing the Effectiveness of Mullein on Respiratory Conditions Such as Asthma”.2016, 10.13140.
10. Micke, D.; "A systematic review of the clinical evidence for Verbascum Thapsus L. in the treatment of respiratory conditions." Phytotherapy Research, 2008, 22(2), 146-150.
11. Galati, E. M., Pergolizzi, S., Miceli, N., Monforte, M. T., Tripodo, M. M.; "Study on the Incremental Effects of Verbascum Thapsus Infusion on Respiratory Health." Phytotherapy Research,2002,16(1), 1-3.
12. Singh, M., & Govil, J. N.; "Respiratory Benefits of Verbascum Thapsus: An Ethnobotanical Review." Journal of Herbal Pharmacotherapy, 2003, 3(4), 57-64.
13. Mahmoud, M. R., Mahmoud, A. E., & Deabes, M. M.; "Pharmacological Study on Verbascum Thapsus L. Leaves and Flowers as Respiratory Support." International Journal of Pharmaceutical Sciences and Research, 2008, 9(2), 119-124.
14. Sampson, J. H., & Kaur, H.; "Antibacterial activity of Verbascum Thapsus (mullein) leaf extract." Journal of Ethnopharmacology, 2003, 88(1), 67-71.
15. Zakavi, F., Golestani, S., & Dadgarineghad, A.; "Antibacterial activity of Verbascum Thapsus L. flower extract against oral pathogens." Journal of Herbal Pharmacotherapy, 2011, 9(4), 290-299.
16. Süntar, I., Keleş, H., & Küpeli Akkol, E.; "Antimicrobial and wound healing properties of Verbascum Thapsus." Journal of Medicinal Plants Research, 2012, 6(34), 4772-4779.
17. Hellinger, R., Koehbach, J., Fedchuk, H., Sauer, B., Huber, R., & Gruber, C. W.; "Immunosuppressive activity of Verbascum Thapsus L. peptides in the treatment of viral infections." Biochemical Pharmacology, 2014, 92(2), 350-357.
18. Ghaffari, H., Rezazadeh, S., Vaziri, N., Gharibi, S., & Soroush, S.; "Antiviral properties of Verbascum Thapsus extracts against herpes simplex virus type 1." Virology Journal, 2018, 15(1), 10-15.
19. Pogány, M., & Holb, I.; "Antiviral and immunomodulatory effects of mullein (Verbascum Thapsus) extract on influenza virus." Acta Virologica, 2006, 50(3),187-193.
20. Kumar, A., & Singh, A. (2013).* "Anthelmintic activity of Verbascum thapsus Linn. leaves extract." Journal of Ethnopharmacology, 148(1), 218-222.
21. Eguale, T., & Giday, M. (2009).* "In vitro anthelmintic activity of three medicinal plants against Haemonchus contortus." Journal of Ethnopharmacology, 127(2), 725-728.
22. Kumar, A., Kumar, P., & Gupta, N. (2011).* "In vitro anthelmintic activity of Verbascum thapsus Linn. flowers." International Journal of Pharmaceutical Sciences and Research, 2(8), 2031-2034.
23. Williams, A. R., & Kahn, L. P. (2008)."The anthelmintic activity of herbal plants: A review of current knowledge and future prospects." Veterinary Parasitology, 159(2), 234-243.
24. Rashed, K., & Butnariu, M. (2014).* "Antioxidant compounds from Verbascum thapsus (mullein) leaves." International Journal of Biomedical Science, 10(1), 64-72.
25. Güder, A., & Korkmaz, H. (2012).* "Evaluation of in vitro antioxidant properties of Verbascum thapsus and Verbascum sinuatum." International Journal of Pharmaceutical Sciences and Research, 3(7), 2057-2062.
26. Patel, D. K., Kumar, R., Prasad, S. K., & Hemalatha, S. (2010).* "Antioxidant activity of some selected medicinal plants in western region of India." Advances in Biological Research, 4(1), 23-26.
27. Saravanakumar, A., Vanitha, J., Ganesh, M., & Kavitha, K. (2014).* "Antioxidant and anti-inflammatory potential of Verbascum thapsus L. leaves." Journal of Medicinal Plants Research, 8(31), 1051-1058.
28. Mokhtar, M., Tahrani, A., Bensouici, C., & Bakour, S. (2018).* "In vivo and in vitro anti-inflammatory activities of Verbascum thapsus L. extracts." Natural Product Research, 32(19), 2338-2342.
29. Carpinella, M. C., Ferrayoli, C. G., & Palacios, S. M. (2005).* "Antinociceptive activity of extracts from Verbascum thapsus L. leaves." Phytomedicine, 12(5), 401-406.
30. Dar, Mohd A., Mohammad F. Bhat, Reyaz Hassan, Mubashir H. Masoodi, Showkat R. Mir, and Roohi Mohiuddin. "Extensive phytochemistry, comprehensive traditional uses, and critical pharmacological profile of the great mullein: Verbascum thapsus L." The Natural Products Journal 9, no. 3 (2019): 158-171.
31. Hussain, H., Aziz, S., Miana, G. A., Ahmad, V. U., Anwar, S., & Ahmed, I. (2009). Minor chemical constituents of Verbascum thapsus. Biochemical systematics and ecology, 37(2), 124-126.
32. Kahraman, C., Akdemir, Z. S., & Tatli, I. I. (2012). Promising cytotoxic activity profile, biological activities and phytochemical screening of Verbascum L. species. Med. Aromat. Plant Sci. Biotechnol, 6(2), 63-75.
33. Liu, C., Chen, K., Zhao, Y., & Wei, C. (2020). A Review on Iridoid Glycosides in Verbascum thapsus: Bioactivities and Pharmacological Properties. Journal of Herbal Medicine, 22, 100354.
34. Ghisalberti, E. L. (1998). Biological and Pharmacological Activity of Iridoids and Iridoid Glycosides. Phytomedicine, 5(2), 147-163.
35. Todorova, M., & Trendafilova, A. (2014). Iridoid Glycosides in Plantago and Verbascum: Distribution and Pharmacological Properties. Journal of Natural Products, 77(2), 436-447.
36. Ghedira, K., Goetz, P., & Le Jeune, R. (2008). Mullein (Verbascum thapsus L.): A Review of Its Traditional Uses, Phytochemistry, and Pharmacology. Phytotherapy Research, 22(1), 71-75.
37. Ulubelen, A., Topçu, G., & Eris, C. (1995). Terpenoids from Verbascum thapsus. Phytochemistry, 38(4), 1007-1010.
38. Kleinschmidt, S., & Jakupovic, J. (1999). Flavonoids and Other Constituents of Verbascum thapsus. Phytochemistry, 51(4), 507-510.
39. Mahboubi, M. (2019). Verbascum thapsus (Mullein) and Its Products: Traditional Uses, Chemical Constituents, and Biological Activities. Evidence-Based Complementary and Alternative Medicine, 2019, 1-13.
40. Al-Snafi, A. E. (2018). Chemical Constituents and Pharmacological Effects of Verbascum thapsus: A Review. Asian Journal of Pharmaceutical Science & Technology, 8(2), 82-87.
41. Orhan, I. E., Tosun, G., & Şener, B. (2010). Fatty Acid Composition of Verbascum thapsus L. from Turkey. Records of Natural Products, 4(1), 19-24.
42. Turker, A. U., Camper, N. D., & Gürel, E. (2004). High-Performance Liquid Chromatographic Determination of A Saponin from Verbascum Thapsus L. Biotechnology & Biotechnological Equipment, 18(1), 54-59.
43. Gupta, A., Atkinson, A. N., Pandey, A. K., & Bishayee, A. (2022). Health‐promoting and disease‐mitigating potential of Verbascum thapsus L.(common mullein): A review. Phytotherapy Research, 36(4), 1507-1522.
44. Fawzi, N. M., & Khalil, M. Y. (2010). Chemical Constituents and Biological Activities of the Aerial Parts of Verbascum thapsus L. Australian Journal of Basic and Applied Sciences, 4(2), 196-204.
45. Babamoradi, N., Yousefi, S., & Ziarati, P. (2018). Optimization of ultrasound‐assisted extraction of functional polysaccharides from common mullein (Verbascum thapsus L.) flowers. Journal of Food Process Engineering, 41(7), e12851.
46. Schilling, E. E., & Hoffmann, J. J. (1984). Phytochemical Studies in the Scrophulariaceae: Flavonoids, Iridoids, and Phenolic Acids of Verbascum. Biochemical Systematics and Ecology, 12(4), 405-413.
2. Blanco-Salas J, Hortigón-Vinagre MP, Morales-Jadán D, Ruiz-Téllez T; “A Review on the Case of Mullein (Verbascum, Scrophulariaceae).” 2021,10(7), 618.
3. Arzu Uçar Turker & Gurel Ekrem; “Common Mullein (Verbascum Thapsus L.): Recent Advances in Research”. Phytotherapy Research, 2005,19(9) 733– 739.
4. N.D Camper & Arzu Ucar Turker; “Biological Activity of Common Mullein, A Medicinal Plant”. The Journal of Ethnopharmacology, 2002,8(2), 117-125.
5. Mayank A. Panchal, Krishna Murti, Vijay Lambole, “Pharmacological Properties of Verbascum Thapsus-A Review”. International Journal of Pharmaceutical Sciences Review and Research, 2010, 5(2), 73-77.
6. Ahmed, M., & Fatima, M.; “Anti-inflammatory and Antioxidant Activity of Verbascum Thapsus L. (Scrophulariaceae).” Journal of Ethnopharmacology, 2016,182.
7. Zhang, Y., Wang, P.; “Histological Examination of the Lung Protective Effects of Verbascum Thapsus Extract in a Murine Model.” 2018, 33(4), 435-442.
8. Martínez, M., & Espinosa; “Therapeutic Potential of Verbascum Thapsus in Traditional and Modern Medicine”. Phytomedicine, 2019, 60, 152.
9. Rachelle Karman, “Assessing the Effectiveness of Mullein on Respiratory Conditions Such as Asthma”.2016, 10.13140.
10. Micke, D.; "A systematic review of the clinical evidence for Verbascum Thapsus L. in the treatment of respiratory conditions." Phytotherapy Research, 2008, 22(2), 146-150.
11. Galati, E. M., Pergolizzi, S., Miceli, N., Monforte, M. T., Tripodo, M. M.; "Study on the Incremental Effects of Verbascum Thapsus Infusion on Respiratory Health." Phytotherapy Research,2002,16(1), 1-3.
12. Singh, M., & Govil, J. N.; "Respiratory Benefits of Verbascum Thapsus: An Ethnobotanical Review." Journal of Herbal Pharmacotherapy, 2003, 3(4), 57-64.
13. Mahmoud, M. R., Mahmoud, A. E., & Deabes, M. M.; "Pharmacological Study on Verbascum Thapsus L. Leaves and Flowers as Respiratory Support." International Journal of Pharmaceutical Sciences and Research, 2008, 9(2), 119-124.
14. Sampson, J. H., & Kaur, H.; "Antibacterial activity of Verbascum Thapsus (mullein) leaf extract." Journal of Ethnopharmacology, 2003, 88(1), 67-71.
15. Zakavi, F., Golestani, S., & Dadgarineghad, A.; "Antibacterial activity of Verbascum Thapsus L. flower extract against oral pathogens." Journal of Herbal Pharmacotherapy, 2011, 9(4), 290-299.
16. Süntar, I., Keleş, H., & Küpeli Akkol, E.; "Antimicrobial and wound healing properties of Verbascum Thapsus." Journal of Medicinal Plants Research, 2012, 6(34), 4772-4779.
17. Hellinger, R., Koehbach, J., Fedchuk, H., Sauer, B., Huber, R., & Gruber, C. W.; "Immunosuppressive activity of Verbascum Thapsus L. peptides in the treatment of viral infections." Biochemical Pharmacology, 2014, 92(2), 350-357.
18. Ghaffari, H., Rezazadeh, S., Vaziri, N., Gharibi, S., & Soroush, S.; "Antiviral properties of Verbascum Thapsus extracts against herpes simplex virus type 1." Virology Journal, 2018, 15(1), 10-15.
19. Pogány, M., & Holb, I.; "Antiviral and immunomodulatory effects of mullein (Verbascum Thapsus) extract on influenza virus." Acta Virologica, 2006, 50(3),187-193.
20. Kumar, A., & Singh, A. (2013).* "Anthelmintic activity of Verbascum thapsus Linn. leaves extract." Journal of Ethnopharmacology, 148(1), 218-222.
21. Eguale, T., & Giday, M. (2009).* "In vitro anthelmintic activity of three medicinal plants against Haemonchus contortus." Journal of Ethnopharmacology, 127(2), 725-728.
22. Kumar, A., Kumar, P., & Gupta, N. (2011).* "In vitro anthelmintic activity of Verbascum thapsus Linn. flowers." International Journal of Pharmaceutical Sciences and Research, 2(8), 2031-2034.
23. Williams, A. R., & Kahn, L. P. (2008)."The anthelmintic activity of herbal plants: A review of current knowledge and future prospects." Veterinary Parasitology, 159(2), 234-243.
24. Rashed, K., & Butnariu, M. (2014).* "Antioxidant compounds from Verbascum thapsus (mullein) leaves." International Journal of Biomedical Science, 10(1), 64-72.
25. Güder, A., & Korkmaz, H. (2012).* "Evaluation of in vitro antioxidant properties of Verbascum thapsus and Verbascum sinuatum." International Journal of Pharmaceutical Sciences and Research, 3(7), 2057-2062.
26. Patel, D. K., Kumar, R., Prasad, S. K., & Hemalatha, S. (2010).* "Antioxidant activity of some selected medicinal plants in western region of India." Advances in Biological Research, 4(1), 23-26.
27. Saravanakumar, A., Vanitha, J., Ganesh, M., & Kavitha, K. (2014).* "Antioxidant and anti-inflammatory potential of Verbascum thapsus L. leaves." Journal of Medicinal Plants Research, 8(31), 1051-1058.
28. Mokhtar, M., Tahrani, A., Bensouici, C., & Bakour, S. (2018).* "In vivo and in vitro anti-inflammatory activities of Verbascum thapsus L. extracts." Natural Product Research, 32(19), 2338-2342.
29. Carpinella, M. C., Ferrayoli, C. G., & Palacios, S. M. (2005).* "Antinociceptive activity of extracts from Verbascum thapsus L. leaves." Phytomedicine, 12(5), 401-406.
30. Dar, Mohd A., Mohammad F. Bhat, Reyaz Hassan, Mubashir H. Masoodi, Showkat R. Mir, and Roohi Mohiuddin. "Extensive phytochemistry, comprehensive traditional uses, and critical pharmacological profile of the great mullein: Verbascum thapsus L." The Natural Products Journal 9, no. 3 (2019): 158-171.
31. Hussain, H., Aziz, S., Miana, G. A., Ahmad, V. U., Anwar, S., & Ahmed, I. (2009). Minor chemical constituents of Verbascum thapsus. Biochemical systematics and ecology, 37(2), 124-126.
32. Kahraman, C., Akdemir, Z. S., & Tatli, I. I. (2012). Promising cytotoxic activity profile, biological activities and phytochemical screening of Verbascum L. species. Med. Aromat. Plant Sci. Biotechnol, 6(2), 63-75.
33. Liu, C., Chen, K., Zhao, Y., & Wei, C. (2020). A Review on Iridoid Glycosides in Verbascum thapsus: Bioactivities and Pharmacological Properties. Journal of Herbal Medicine, 22, 100354.
34. Ghisalberti, E. L. (1998). Biological and Pharmacological Activity of Iridoids and Iridoid Glycosides. Phytomedicine, 5(2), 147-163.
35. Todorova, M., & Trendafilova, A. (2014). Iridoid Glycosides in Plantago and Verbascum: Distribution and Pharmacological Properties. Journal of Natural Products, 77(2), 436-447.
36. Ghedira, K., Goetz, P., & Le Jeune, R. (2008). Mullein (Verbascum thapsus L.): A Review of Its Traditional Uses, Phytochemistry, and Pharmacology. Phytotherapy Research, 22(1), 71-75.
37. Ulubelen, A., Topçu, G., & Eris, C. (1995). Terpenoids from Verbascum thapsus. Phytochemistry, 38(4), 1007-1010.
38. Kleinschmidt, S., & Jakupovic, J. (1999). Flavonoids and Other Constituents of Verbascum thapsus. Phytochemistry, 51(4), 507-510.
39. Mahboubi, M. (2019). Verbascum thapsus (Mullein) and Its Products: Traditional Uses, Chemical Constituents, and Biological Activities. Evidence-Based Complementary and Alternative Medicine, 2019, 1-13.
40. Al-Snafi, A. E. (2018). Chemical Constituents and Pharmacological Effects of Verbascum thapsus: A Review. Asian Journal of Pharmaceutical Science & Technology, 8(2), 82-87.
41. Orhan, I. E., Tosun, G., & Şener, B. (2010). Fatty Acid Composition of Verbascum thapsus L. from Turkey. Records of Natural Products, 4(1), 19-24.
42. Turker, A. U., Camper, N. D., & Gürel, E. (2004). High-Performance Liquid Chromatographic Determination of A Saponin from Verbascum Thapsus L. Biotechnology & Biotechnological Equipment, 18(1), 54-59.
43. Gupta, A., Atkinson, A. N., Pandey, A. K., & Bishayee, A. (2022). Health‐promoting and disease‐mitigating potential of Verbascum thapsus L.(common mullein): A review. Phytotherapy Research, 36(4), 1507-1522.
44. Fawzi, N. M., & Khalil, M. Y. (2010). Chemical Constituents and Biological Activities of the Aerial Parts of Verbascum thapsus L. Australian Journal of Basic and Applied Sciences, 4(2), 196-204.
45. Babamoradi, N., Yousefi, S., & Ziarati, P. (2018). Optimization of ultrasound‐assisted extraction of functional polysaccharides from common mullein (Verbascum thapsus L.) flowers. Journal of Food Process Engineering, 41(7), e12851.
46. Schilling, E. E., & Hoffmann, J. J. (1984). Phytochemical Studies in the Scrophulariaceae: Flavonoids, Iridoids, and Phenolic Acids of Verbascum. Biochemical Systematics and Ecology, 12(4), 405-413.
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Dec 11, 2024
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Riya Vaghela, Nadim Chhipa, & Pragnesh Patani. (2024). A BRIEF REVIEW ON PHARMACOLOGICAL BENEFITS OF VERBASCUM THAPSUS L. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1026-1036. https://doi.org/10.53555/eykbsw88
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Author Biographies
Riya Vaghela
Department of Pharmacy, Khyati College of Pharmacy, Palodia, Ahmedabad
Nadim Chhipa
Associate Professor, Department of Pharmaceutical Chemistry, Khyati College of Pharmacy, Palodia, Ahmedabad
Pragnesh Patani
Principal and Professor, Department of Pharmacology, Khyati College of Pharmacy, Palodia, Ahmedabad
How to Cite
Riya Vaghela, Nadim Chhipa, & Pragnesh Patani. (2024). A BRIEF REVIEW ON PHARMACOLOGICAL BENEFITS OF VERBASCUM THAPSUS L. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1026-1036. https://doi.org/10.53555/eykbsw88