DIAGNOSTIC ACCURACY OF SERUM C-REACTIVE PROTEIN LEVELS IN ACUTE APPENDICITIS
Main Article Content
Keywords
Surgeons, acute appendicitis, C- reactive protein, inflammatory markers
Abstract
Introduction: Acute appendicitis is one of the most prevalent disease in Pakistan as well as worldwide. Patients who face the disease are very much miserable. Accurate and instant diagnosis is a big challenge faced by the surgeons in emergency departments of tertiary care hospitals, failure in these, results in further complications. Latest maximum diagnosis tools must be used deliberately to mitigate errors such that to palliate the patients. The study was designed to evaluate the correct diagnostic ability of CRP pertaining to acute appendicitis so that negative appendectomy rates are cut short.
Methodology: The study was executed in Surgical B Unit of Khyber Teaching Hospital at Peshawar, Khyber Pakhtunkhwa, Pakistan from 27th June to 26th December 2022 over 210 patients complaining of pain abdomen.
Results: Raised levels of inflammatory markers like C reactive protein (CRP) in a clinically suspected case of acute appendicitis suggest early exploration. It also has more diagnostic accuracy than ESR and leucocyte count in detecting inflammatory processes.
Conclusion: CRP is very important for the correct diagnosis of acute appendicitis along with other imaginary tools which must be used simultaneously.
Methodology: The study was executed in Surgical B Unit of Khyber Teaching Hospital at Peshawar, Khyber Pakhtunkhwa, Pakistan from 27th June to 26th December 2022 over 210 patients complaining of pain abdomen.
Results: Raised levels of inflammatory markers like C reactive protein (CRP) in a clinically suspected case of acute appendicitis suggest early exploration. It also has more diagnostic accuracy than ESR and leucocyte count in detecting inflammatory processes.
Conclusion: CRP is very important for the correct diagnosis of acute appendicitis along with other imaginary tools which must be used simultaneously.
References
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6. Demetrashvili Z., Kenchadze G., Pipia I., Ekaladze E. and Kamkamidze G. Management of Appendiceal Mass and Abscess. An 11-Year Experience. Int. Surg. 2015, 100: 1021-1025.
7. Wagner M., Tubre D.J. and Asensio J.A. Evolution and current trends in the management of acute appendicitis. Surg. Clinc. North Am. 2018, 98: 1005-1023.
8. Snyder M.J., Guthrie M. and Cagle S. Acute appendicitis: efficient diagnosis and management. Am. Fam. Physician. 2018, 98: 25-33.
9. Demetrashvili Z., Kenchadze G., Pipia I., Khutsishvili K., Loladze D. and Ekaladze E. et al. Comparison of treatment methods of appendiceal mass and abscess: A prospective Cohort Study. Ann. Med. Surg. (Lond.) 2019, 48: 48-52.
10. Buderer N.M. Statistical methodology: I. Incorporating the prevalence of disease into the sample size calculation for sensitivity and specificity. Acad Emerg Med. 1996, 3(9): 895-900.
11. Bolin E. and Lam W. A. A review of sensitivity, specificity and likelihood ratios: evaluating the utility of the electrocardiogram as a screening tool in hypertrophic cardiomyopathy. Congenit Heart Dis. 2013, 8(5): 406-410.
12. Parikh R., Mathai A, Parikh S., Chandra Sekhar G. and Thomas R. Understanding and using sensitivity, specificity and predictive values. Indian J. Ophthalmol. 2008, 56(1): 45-50.
13. Ion D., Serban M.B., Paduraru D.N., Nica A.E. and Rahim A.M. Andronic O. Appendiceal mass - dilemmas regarding extension of the resection. Chirurgia (Bucur) 2019; 114: 126-130.
14. Bahram M.A. Evaluation of early surgical management of complicated appendicitis by appendicular mass. Int. J. Surg. 2011; 9: 101-103.
15. Hung-wen L., Che-Chuan L., Wu C. and Lui W.Y. Watch waiting versus interval Appendectomy for patients who recovered from appendicitis with tumor formation: A cost-effectiveness analysis. Chin. J. Med. 2005; 68: 431- 434.
16. Kollar D., McCartan D.P., Bourke M., Cross K.S. and Dowdall J. Predicting acute appendicitis? A comparison of the Alvarado score, the appendicitis inflammatory response score and clinical assessment. World J. Surg. 2015; 39: 104–09.
17. Hansson J., Khorram-Manesh A., Alwindawe A. and Lundholm K. A model to select patients who may benefit from antibiotic therapy as the first line treatment of acute appendicitis at high probability. J Gastro intestine Surg. 2014; 18: 961-967.
18. Ohle R., O’Reilly F., O’Brien K.K. and Fahey T. and Dimitrov B.D. The Alvarado score for predicting acute appendicitis: a systematic review. BMC Med. 2011; 9: 139.
19. Di Saverio S., Mandrioli M. and Sibilio A., et al. A cost-effective technique for laparoscopic appendectomy: outcomes and costs of a case-control prospective single-operator study of 112 unselected consecutive cases of complicated acute appendicitis. J. Am. College Surg. 2014; 218: 51-65.
20. Ohene-Yeboah M. and Togbe B. An audit of appendicitis and appendectomy in Kumasi, Ghana. West Afr. J. Med. 2006; 25: 138-43.
2. Maistrenko N.A., Romashchenko P.N., Yagin M.V. Appendiceal mass: diagnostics and treatment strategy. VestnKhirIm II Grek. 2016; 175: 57-62.
3. Jones M. W., Lopez R.A. and Deppen J.G. Appendicitis. Stat pearls. ed. Treasure Island: Stat Pearls Publishing; 2020.
4. Lee J.H., Park Y.S. and Choi J.S. The epidemiology of appendicitis and appendectomy in South Korea: national registry data. J. Epidemiol. 2010, 20(2): 97-105.
5. Sulu B., Günerhan Y., Palanci Y., Işler B. and Cağlayan K. Epidemiological and demographic features of appendicitis and influences of several environmental factors. Turk J Trauma Emerg. Surg: TJTES. 2010, 16(1): 38-42.
6. Demetrashvili Z., Kenchadze G., Pipia I., Ekaladze E. and Kamkamidze G. Management of Appendiceal Mass and Abscess. An 11-Year Experience. Int. Surg. 2015, 100: 1021-1025.
7. Wagner M., Tubre D.J. and Asensio J.A. Evolution and current trends in the management of acute appendicitis. Surg. Clinc. North Am. 2018, 98: 1005-1023.
8. Snyder M.J., Guthrie M. and Cagle S. Acute appendicitis: efficient diagnosis and management. Am. Fam. Physician. 2018, 98: 25-33.
9. Demetrashvili Z., Kenchadze G., Pipia I., Khutsishvili K., Loladze D. and Ekaladze E. et al. Comparison of treatment methods of appendiceal mass and abscess: A prospective Cohort Study. Ann. Med. Surg. (Lond.) 2019, 48: 48-52.
10. Buderer N.M. Statistical methodology: I. Incorporating the prevalence of disease into the sample size calculation for sensitivity and specificity. Acad Emerg Med. 1996, 3(9): 895-900.
11. Bolin E. and Lam W. A. A review of sensitivity, specificity and likelihood ratios: evaluating the utility of the electrocardiogram as a screening tool in hypertrophic cardiomyopathy. Congenit Heart Dis. 2013, 8(5): 406-410.
12. Parikh R., Mathai A, Parikh S., Chandra Sekhar G. and Thomas R. Understanding and using sensitivity, specificity and predictive values. Indian J. Ophthalmol. 2008, 56(1): 45-50.
13. Ion D., Serban M.B., Paduraru D.N., Nica A.E. and Rahim A.M. Andronic O. Appendiceal mass - dilemmas regarding extension of the resection. Chirurgia (Bucur) 2019; 114: 126-130.
14. Bahram M.A. Evaluation of early surgical management of complicated appendicitis by appendicular mass. Int. J. Surg. 2011; 9: 101-103.
15. Hung-wen L., Che-Chuan L., Wu C. and Lui W.Y. Watch waiting versus interval Appendectomy for patients who recovered from appendicitis with tumor formation: A cost-effectiveness analysis. Chin. J. Med. 2005; 68: 431- 434.
16. Kollar D., McCartan D.P., Bourke M., Cross K.S. and Dowdall J. Predicting acute appendicitis? A comparison of the Alvarado score, the appendicitis inflammatory response score and clinical assessment. World J. Surg. 2015; 39: 104–09.
17. Hansson J., Khorram-Manesh A., Alwindawe A. and Lundholm K. A model to select patients who may benefit from antibiotic therapy as the first line treatment of acute appendicitis at high probability. J Gastro intestine Surg. 2014; 18: 961-967.
18. Ohle R., O’Reilly F., O’Brien K.K. and Fahey T. and Dimitrov B.D. The Alvarado score for predicting acute appendicitis: a systematic review. BMC Med. 2011; 9: 139.
19. Di Saverio S., Mandrioli M. and Sibilio A., et al. A cost-effective technique for laparoscopic appendectomy: outcomes and costs of a case-control prospective single-operator study of 112 unselected consecutive cases of complicated acute appendicitis. J. Am. College Surg. 2014; 218: 51-65.
20. Ohene-Yeboah M. and Togbe B. An audit of appendicitis and appendectomy in Kumasi, Ghana. West Afr. J. Med. 2006; 25: 138-43.
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Published
Jul 11, 2024
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Dr. Nazish, Dr. Spogmay Naeem, Dr. Fatma, Dr. Irum Sabir Ali, Dr. Rabia Ali, & Kaukab Naeem. (2024). DIAGNOSTIC ACCURACY OF SERUM C-REACTIVE PROTEIN LEVELS IN ACUTE APPENDICITIS. Journal of Population Therapeutics and Clinical Pharmacology, 31(7), 1865-1872. https://doi.org/10.53555/2tq1hv76
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Author Biographies
Dr. Nazish
Surgical B Unit, Khyber Teaching Hospital Peshawar, Khyber Pakhtunkhwa, Pakistan
Dr. Spogmay Naeem
Surgical B Unit, Khyber Teaching Hospital Peshawar, Khyber Pakhtunkhwa, Pakistan
Dr. Fatma
Surgical B Unit, Khyber Teaching Hospital Peshawar, Khyber Pakhtunkhwa, Pakistan
Dr. Irum Sabir Ali
Surgical B Unit, Khyber Teaching Hospital Peshawar, Khyber Pakhtunkhwa, Pakistan
Dr. Rabia Ali
Surgical B Unit, Khyber Teaching Hospital Peshawar, Khyber Pakhtunkhwa, Pakistan
Kaukab Naeem
Category D Hospital Thana, District Malakand, Khyber Pakhtunkhwa, Pakistan.
How to Cite
Dr. Nazish, Dr. Spogmay Naeem, Dr. Fatma, Dr. Irum Sabir Ali, Dr. Rabia Ali, & Kaukab Naeem. (2024). DIAGNOSTIC ACCURACY OF SERUM C-REACTIVE PROTEIN LEVELS IN ACUTE APPENDICITIS. Journal of Population Therapeutics and Clinical Pharmacology, 31(7), 1865-1872. https://doi.org/10.53555/2tq1hv76