PSEUDOMONAS AERUGINOSA: EMERGING THREAT TO POST OPERATIVE WOUND INFECTION.

Main Article Content

Pranjal Nema
Prashant Parmar
Narendra Babu
Anushi Hardaha
Amardeep Rai

Keywords

Antimicrobial resistance, Pseudomonas aeruginosa, postoperative wound, prevalence

Abstract

Background - . In the recent condition, the growing incidence of P. aeruginosa has been increasing in  post operative wound infection and becoming more serious problem  in developing countries because of lack of general hygienic measures and mass production of low quality antiseptic : The aim  of this study was to determine the prevalence of Pseudomonas aeruginosa in  postoperative wound  infection and its susceptibility pattern.


Methodology


Study design- Retrospective observational Study.


Study Centre- Bundelkhand Medical College, Sagar, Madhya Pradesh


Study duration- September 2021 to June 2022.


Methods and material –This is a record based study of 10 month duration. 252 patients were enrolled for the study and their post operative wound swab received were processed for identification of bacterial pathogens .


Result –Out of 252 wound swabs, 80(34.7%) were P. aeruginosa, followed by Escherichia coli (52/22.6%), Klebsiella spp.(46/20%), Staphylococcus aureus(35/15.2%), Proteus spp.(13/5.6%), Acinetobacter spp. (4/1.7%).There was no growth in (22/8.7%) wound swabs.


Interpretation & conclusions -Our study shows that P. aeruginosa was most prevalent (34.7%) the pathogens isolated from the surgical wounds. The primary reason for this increase in postoperative infection rate with prolonged preoperative hospitalization may be the colonization of patients with hospital-acquired resistant microorganisms.


 

Abstract 37 | pdf Downloads 11

References

1. Kirkland KB, Briggs JP, Trivette SL, Wilkinson WE, Sexton DJ. The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs. Infect Control Hosp Epidemiol. 1999;20:725–30. doi: 10.1086/501572. [DOI] [PubMed] [Google Scholar]
2. Calvin M. Cutaneous wound repair. Wounds. 1998;10:12–32. [Google Scholar]
3. Khan JA, Iqbal Z, Rahman SU, Farzana K, Khan A. Report: prevalence and resistance pattern of Pseudomonas aeruginosa against various antibiotics. Pak J Pharm Sci. 2008;21:311–5. [PubMed] [Google Scholar]
4. Bodey GP, Bolivar R, Fainstein V, Jadeja L. Infections caused by Pseudomonas aeruginosa. Rev Infect Dis. 1983;5:279–313. doi: 10.1093/clinids/5.2.279. [DOI] [PubMed] [Google Scholar]
5. Livermore DM. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare? Clin Infect Dis. 2002;34:634–40. doi: 10.1086/338782. [DOI] [PubMed] [Google Scholar]
6. Mousa H. Aerobic, anaerobic and fungal burn wound infections. J Hosp Infect. 1997;37:317–23. doi: 10.1016/s0195-6701(97)90148-1. [DOI] [PubMed] [Google Scholar]
7. National Nosocomial Infections Surveillance (NNIS) System. NNIS report, data summary from January 1992 to June 2002, issued August 2002. Am J Infect Control. 2002;30:458–75. doi: 10.1067/mic.2002.130032. [DOI] [PubMed] [Google Scholar]
8. Leigh DA, Emmanuel FX, Sedgwick J, Dean R. Post-operative urinary tract infection and wound infection in women undergoing caesarean section: A comparison of two study periods in 1985 and 1987. J Hosp Infect. 1990;15:107–16. doi: 10.1016/0195-6701(90)90119-9. [DOI] [PubMed] [Google Scholar]
9. Leigh DA, Emmanuel FX, Sedgwick J, Dean R. Post-operative urinary tract infection and wound infection in women undergoing caesarean section: A comparison of two study periods in 1985 and 1987. J Hosp Infect. 1990;15:107–16. doi: 10.1016/0195-6701(90)90119-9. [DOI] [PubMed] [Google Scholar]
10. Russell RC, Williams NS, Bulstrode CJ. Bailey and Love’s Short Practice of Surgery. 23rd ed. USA: Oxford Press; 2000. pp. 87–98. [Google Scholar]
11. Andenaes K, Lingaas E, Amland PF, Giercksky KE, Abyholm F. Preoperative bacterial colonization and its influence on post operative wound infection in plastic surgery. J Hosp Infect. 1996;34:291–9. doi: 10.1016/s0195-6701(96)90109-7. [DOI] [PubMed] [Google Scholar]
12. Trilla A. Epidemiology of nosocomial infections in adult intensive care units. Intensive Care Med. 1994;20:1–4. doi: 10.1007/BF01745243. [DOI] [PubMed] [Google Scholar]
13. Bertrand XM, Thouverez C, Patry P, Balvay, Talon D. Pseudomonas aeruginosa: antibiotic susceptibility and genotypic characterization of strains isolated in the intensive care unit. Clin Microbiol Infect. 2002;7:706–8. [PubMed] [Google Scholar]
14. Forbes BA, Sahm DF, Weissfeld AS. Pseudomonas, Burkholderia, and similar organisms. In: Forbes BA, Sahm DF, Weissfeld AS, editors. Bailey and Scott’s Diagnostic Microbiology. 11th ed. Louis: Mosby Inc; 2002. pp. 448–61. [Google Scholar]
15. Central Laboratory Standards Institute (CLSI) Central Laboratory Standards Institute (CLSI). Performance standards for antimicrobial disc susceptibility tests, Approved standards. Vol 29 CLSI document M02-A10, No1. [Google Scholar]
16. Anupurba S, Bhattacharjee A, Garg A, Sen MR. Antimicrobial susceptibility of Pseudomonas aeruginosa from wound infections. Indian J Dermatol. 2006;51:286–8. [Google Scholar]
17. Oguntibeju OO, Nwobu RAU. Occurrence of Pseudomonas aeruginosa in post-operative wound infection. Pak J Med Sci. 2004;20:187–92. [Google Scholar]
18. Masaadeh HA, Jaran AS. Incident of Pseudomonas aeruginosa in post-operative wound infection. Am J Infect Dis. 2009;5:1–6. [Google Scholar]
19. Oguntibeju OO, Nwobu RAU. Occurrence of Pseudomonas aeruginosa in post-operative wound infection. Pak J Med Sci. 2004;20:187–92. [Google Scholar]
20. Masaadeh HA, Jaran AS. Incident of Pseudomonas aeruginosa in post-operative wound infection. Am J Infect Dis. 2009;5:1–6. [Google Scholar]
21. Siguan SS, Ang BS, Pala IM, Baclig RM. Aerobic Surgical Infection: surveillance on microbiological etiology and antimicrobial sensitivity pattern of commonly used antibiotics. Phil J Microbiol Infect Dis. 1990;19:27–33. [Google Scholar]
22. Navaneeth BV, Sridaran D, Sahay D, Belwadi MR. A preliminary study on metallo-beta-lactamase producing Pseudomonas aeruginosa in hospitalized patients. Indian J Med Res. 2002;116:264–7. [PubMed] [Google Scholar]
23. Bonfiglio G, Carciotto V, Russo G, Stefani S, Schito GC, Debbia E, et al. Antibiotic resistance in Pseudomonas aeruginosa: an Italian survey. J Antimicrob Chemother. 1998;41:307–10. doi: 10.1093/jac/41.2.307. [DOI] [PubMed] [Google Scholar]
24. Goossens H. Susceptibility of multi-drug-resistant Pseudomonas aeruginosa in intensive care units: results from the European MYSTIC study group. Clin Microbiol Infect. 2003;9:980–3. doi: 10.1046/j.1469-0691.2003.00690.x. [DOI] [PubMed] [Google Scholar]
25. Kohler T, Michea-Hamzehpour M, Epp SF, Pechere JC. Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems. Antimicrob Agents Chemother. 1999;43:424–7. doi: 10.1128/aac.43.2.424. [DOI] [PMC free article] [PubMed] [Google Scholar]

Most read articles by the same author(s)