DEVELOPMENT & EVALUATION OF TASTE MASKED LEVOCETRIZINE DIHYDROCHLORIDE & MONTELUKAST SODIUM FAST-DISSOLVING TABLET
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Keywords
FDT, Pre-compression study, post-compression study, Stability study, Similar factor, Difference factor
Abstract
The goal of the current study was to use the direct compression method to create and assess the orodispersible (rapid dissolving) tablets of Montelukast sodium and Taste-masked Levocetrizine dihydrochloride. Ion exchange resins such as Kyron-T-114 and Kyron-T-130 were used to taste mask the medication in order to avoid its unpleasant odor and harsh taste. The substance was identified using a variety of techniques, including stability studies, pH, organoleptic characteristics, drug releasing profiles, and other testing. Kyron-T-114, one of the two resins, was chosen for additional research due to its superior drug release profile, low cost, and high drug loading capacity. Kyron T-114 is a high molecular weight, cross-linked polymer of methacrylic acid that is insoluble in water. Microcrystalline cellulose (MCC) was used as a diluent in the preparation of the tablets, coupled with three distinct superdisintegrants and their varying ratios. Crosspovidone, sodium starch glycolate, and croscarmellose sodium were the super disintegrants used in this investigation. Weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time (DT), and dissolution studies were all assessed for the tablets. Based on the results, it can be said that the tablet formulation made with 1.5% SSG+CP had good drug release and a better disintegration time than other formulations. The major peaks of pure medicines are unaltered, according to the IR spectrum analyses. This further attests to the purity of pharmaceuticals and their compatibility with excipients.
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Niraj
OPJS University, Jhunjhunu Road, Rajgarh, Churu, Rajasthan, 331303
Dr. Anil Middha
OPJS University, Jhunjhunu Road, Rajgarh, Churu, Rajasthan, 331303