HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF): TREATMENT OPTIONS AND PATIENT OUTCOMES
Main Article Content
Keywords
: Heart Failure with Preserved Ejection Fraction, HFpEF, treatment options, , patient outcomes, pharmacological therapies, non-pharmacological interventions
Abstract
Hu et al specified that HFpEF is undoubtedly a major as well as a diverse structural type of heart failure affecting nearly half of the new patients identified globally. Compared to HFrEF, a similar situation is observed in HFpEF where the underlying mechanisms of the disease are broader and it is extremely difficult to manage the disorder. This study found that, despite optimal medical therapy, patients with HFpEF had marked symptom burden, high hospitalization rate, and reduced health-related quality of life, indicating the need for better therapeutic management strategies. The systematic review of the current treatment of patients diagnosed with HFpEF will focus on the effectiveness of the current treatments. In this regard, the review aims to determine the knowledge gaps that are evident within available literature and proposals for subsequent clinical investigations. The current literature search incorporated the databases PubMed, Cochrane Library, Embase, and Web of Science, adhering to the PRISMA protocol. Article inclusion was guided by specific conditions namely, clinical trials, observation studies, and systemic reviews comparing treatments for HFpEF. Data extraction and quality assessment were performed using standard tools that made the tools very reliable and valid. Overall, the review found 45 closed trials that met the eligibility criterion. Previous pharmacological treatments including the ARNIs, SGLT2i and MRAs had a modest effect in decreasing CV hospitalizations but had a neutral to small effect on all-cause mortality. Frequent devices such as lifestyle changes and exercise protocols were seen to upgrade functional ability besides increasing the quality of life of HFpEF. However, none of these treatments are highly effective, always necessitating a combination and individualized treatment approach. In conclusion, the therapy of HFpEF presents itself with several therapeutic options that have shown promising results but the complexity of the disorder is due to the wide divergence in its clinical presentation. These results suggest that pharmacotherapy should be further complemented with lifestyle modifications to improve the functioning of patients. More work has to be done to precisely define individual therapeutic approaches addressing the heterogeneous pathophysiology of HFpEF and to set clear clinical recommendations.
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32. Nopp, S., Moik, F., Klok, F. A., Gattinger, D., Petrovic, M., Vonbank, K., ... & Zwick, R. H. (2022). Outpatient pulmonary rehabilitation in patients with long COVID improves exercise capacity, functional status, dyspnea, fatigue, and quality of life. Respiration, 101(6), 593-601.
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34. Passantino, A., Dalla Vecchia, L. A., Corrà, U., Scalvini, S., Pistono, M., Bussotti, M., ... & La Rovere, M. T. (2021). The future of exercise-based cardiac rehabilitation for patients with heart failure. Frontiers in cardiovascular medicine, 8, 709898.
35. Peverill, M., Dirks, M. A., Narvaja, T., Herts, K. L., Comer, J. S., & McLaughlin, K. A. (2021). Socioeconomic status and child psychopathology in the United States: A meta-analysis of population-based studies. Clinical psychology review, 83, 101933.
36. Pfeffer, M. A., Shah, A. M., & Borlaug, B. A. (2019). Heart failure with preserved ejection fraction in perspective. Circulation research, 124(11), 1598-1617.
37. Prakash, A., Singh, H., Kaur, H., Semwal, A., Sarma, P., Bhattacharyya, A., ... & Medhi, B. (2020). Systematic review and meta-analysis of effectiveness and safety of favipiravir in the management of novel coronavirus (COVID-19) patients. Indian Journal of Pharmacology, 52(5), 414-421.
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39. Rodriguez‐Mañas, L., Laosa, O., Vellas, B., Paolisso, G., Topinkova, E., Oliva‐Moreno, J., ... & European MID‐Frail Consortium. (2019). Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus. Journal of cachexia, sarcopenia and muscle, 10(4), 721-733.
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Dec 14, 2024
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Dr. Aisha Alyassi, Dr. Anitha Panneerselvam, Azka Arshad, Arij Alasfour, Muhammad Ans Habib, Fatma Almadani, Dr.Ameera Alaleeli, Mahra Salem Mubarak Albreiki, & Dr.Hadjer Salem. (2024). HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF): TREATMENT OPTIONS AND PATIENT OUTCOMES. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1346-1365. https://doi.org/10.53555/nb1fwf58
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Author Biographies
Dr. Aisha Alyassi
Medical intern at Sheikh Shakhbout Medical city, Abudhabi- UAE,
Dr. Anitha Panneerselvam
Dalian Medical University
Azka Arshad
International School of Medicine (international university of Kyrgyzstan),
Arij Alasfour
University of Sharjah - College of Medicine
Muhammad Ans Habib
International Higher School Of medicine
Fatma Almadani
University of Sharjah
Dr.Ameera Alaleeli
UAE SSMC intern
Mahra Salem Mubarak Albreiki
University of Sharjah
Dr.Hadjer Salem
Ferhat Abbas Sétif University 1, Algeria
How to Cite
Dr. Aisha Alyassi, Dr. Anitha Panneerselvam, Azka Arshad, Arij Alasfour, Muhammad Ans Habib, Fatma Almadani, Dr.Ameera Alaleeli, Mahra Salem Mubarak Albreiki, & Dr.Hadjer Salem. (2024). HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF): TREATMENT OPTIONS AND PATIENT OUTCOMES. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 1346-1365. https://doi.org/10.53555/nb1fwf58