ASSOCIATION BETWEEN NEONATAL ICU ADMISSION AND LOW CORD BLOOD PH
Main Article Content
Keywords
Apgar Score, Low Cord Blood pH, Neonate, NICU admission
Abstract
Objective: The assessment of umbilical cord arterial blood provides the foundation for current clinical practice when evaluating a neonate's status. Therefore, the present study aimed to determine the association between neonatal ICU admission and low cord blood pH.
Methodology: This was a Prospective cohort study conducted in the Department of Obstetrics & Gynecology, Liaquat National Hospital and Medical College, Karachi from 1st July 2023 to 31st December 2023 (six months). Detailed history, physical examination, and anthropometric and biochemical measurements were recorded. Patients were followed postoperatively for adverse outcomes.
Results: A total of 60 participants, 30 from each group were evaluated. Out of 30 neonates in the unexposed group (pH >7.2) only three were admitted to NICU, the rest of the 27 were not admitted to NICU. However, in the exposed group (pH <7.2) out of 30 neonates 10 were admitted to NICU. Mothers aged between 26 – 30 years from the Exposed Group (Acidotic cord pH) have shown a significant relationship with nine of their infants admitted to NICU (p-value = 0.078).
Conclusion: There is a strong association between Neonatal ICU admission and low cord blood pH. This showed that cord blood pH samples can be used to inform clinical management and it is one of the important tools to justify neonatal morbidity and mortality.
References
2. Tasnim N, Mahmud G, Akram S. Predictive accuracy of intrapartum cardiotocography in terms of fetal acid base status at birth. J Coll Physicians Surg Pak 2009; 19(10): 632-5.
3. Williams KP, Singh A. The correlation of seizures in newborn infants with significant acidosis at birth with umbilical artery cord gas values. Obstetrics & Gynecology 2002; 100(3): 557-60.
4. Beeby PJ, Elliott EJ, Henderson-Smart DJ, Rieger ID. Predictive value of umbilical artery pH in preterm infants. Archives of Disease in Childhood-Fetal and Neonatal Edition 1994; 71(2): F93-F6. https://doi.org/10.1136/fn.71.2.F93.
5. Frauenschuh I, Wirbelauer J, Karl S, Girschick G, Rehn M, Zollner U, et al. Prognostic factors of perinatal short-term outcome in severe placental insufficiency using Doppler sonography to assess end-diastolic absent and reverse blood flow in umbilical arteries. Zeitschrift fur Geburtshilfe und Neonatologie 2015; 219(1): 28-36. https://doi.org/10.1055/s-0034-1394387.
6. Perveen F, Khan A, Ali T, Rabia S. Umbilical cord blood pH in intrapartum hypoxia. J Coll Physicians Surg Pak 2015; 25(9): 667-70.
7. Andres RL, Saade G, Gilstrap L, Wilkins I, Witlin A, Zlatnik F, et al. Association between umbilical blood gas parameters and neonatal morbidity and death in neonates with pathologic fetal acidemia. American journal of obstetrics and gynecology 1999; 181(4): 867-71. https://doi.org/10.1016/S0002-9378(99)70316-9.
8. Victory R, Penava D, Da Silva O, Natale R, Richardson B. Umbilical cord pH and base excess values in relation to adverse outcome events for infants delivering at term. American journal of obstetrics and gynecology 2004; 191(6): 2021-8. https://doi.org/10.1016/j.ajog.2004.04.026.
9. Ahmadpour-Kacho M, Zahedpasha Y, Hagshenas M, Rad ZA, Nasseri BS, Bijani A. Short term outcome of neonates born with abnormal umbilical cord arterial blood gases. Iranian journal of pediatrics 2015; 25(3). https://doi.org/10.5812%2Fijp.25(3)2015.174.
10. Dani C, Bresci C, Berti E, Lori S, Di Tommaso MR, Pratesi S. Short term outcome of term newborns with unexpected umbilical cord arterial pH between 7.000 and 7.100. Early Human Development 2013; 89(12): 1037-40. https://doi.org/10.1016/j.earlhumdev.2013.08.012.
11. Yeh P, Emary K, Impey L. The relationship between umbilical cord arterial pH and serious adverse neonatal outcome: analysis of 51 519 consecutive validated samples. BJOG: An International Journal of Obstetrics & Gynaecology 2012; 119(7): 824-31. https://doi.org/10.1111/j.1471-0528.2012.03335.x.
12. Dijxhoorn M, Visser G, Huisjes H, Fidler V, Touwen B. The relation between umbilical pH values and neonatal neurological morbidity in full term appropriate-for-dates infants. Early human development 1985; 11(1): 33-42. https://doi.org/10.1016/0378-3782(85)90117-3.