STUDIES ON ENHANCEMENT OF ORAL BIOAVAILABITY OF PACLITAXEL BY NANO SUSPENSION TECHNOLOGY
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Keywords
paclitaxel nano suspension, SLS, Edragit S 100, PVP K30, poloxamer188.
Abstract
The objective of the present work was to formulate and evaluate drug release paclitaxel nano suspension for treating breast, ovarian and colon cancer effectively. Different formulations were prepared by using Solvent Evaporation technique using synthetic polymer like SLS, Edragit S 100, PVP K30, poloxamer188. The formulations were evaluated for percentage yield, entrapment efficiency, particle size analysis, and In-vitro drug release. The optimized formulation of the Nano suspensions containing polymer and drug was found to be compatible from FTIR studies. The In-vitro release of drug from the formulations were studied in pH 6.8 phosphate buffer solution, and it was found that the prepared nano suspension (F 3) were able to the drug release of the drug 45 mins of about 98.40%. and following the kinetics of first order release.
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Abbineni Anusha
Research Schloar Center for Research studies, Krishna university, Machilipatnam, 521004, A.P., India,
Dr.A.Lakshman rao
Department of Pharmaceutical analysis, V.V. Institute of Pharmaceutical Sciences, Gudlavalleru-521356, A.P., India
Dr.M.V.Basaveswara rao
Department of Chemistry, Krishna University, Machilipatnam-521001, A.P.,India