"IMPACT OF MEAN ARTERIAL PRESSURES MAINTAINED DURING CARDIOPULMONARY BYPASS ON POST-OPERATIVE LACTATE LEVELS IN CORONARY ARTERY BYPASS GRAFTING PATIENTS".
Main Article Content
Keywords
MAP, CPB, CABG, Lactate
Abstract
Lactate, a byproduct of anaerobic metabolism is produced when the body breaks down glucose for energy. The problem with this is that it can build up in the blood stream more quickly than it is eliminated. Lactate is noted to be a marker for cellular hypoxia and tissue hypoperfusion. By monitoring lactate, patients who have an increased risk of post-operative morbidity and mortality can be identified and they may benefit from early aggressive intervention. Hyperlactatemia during cardio pulmonary bypass (CPB) appears to be related mainly to insufficient oxygen delivery and blood flow. This study was aimed to show the impact of mean arterial pressure (MAP) during CPB on the patient’s blood lactate level and post-operative outcomes. 40 patients undergoing coronary artery bypass grafting (CABG) surgery were enrolled for the study. The patients were blindly divided into 2 groups based on the target mean arterial pressure set, as Group-1 [40-60mm Hg] and Group-2 [61-80mm Hg]. All patients underwent CABG surgery on CPB. Perfusion flow rates are well maintained throughout the surgery. Lactate levels, Hemodynamic parameters and Post-operative outcomes of the patients were noted. Results revealed that the Lactate level in Group-2 was low as compared to the Group-1 after surgery. Early extubation and speedy recovery of the patients are also seen in Group-2 patients. This study shows high MAP of 61-80mm Hg during CPB could decrease the blood lactate level and tissue hypoxia.
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Dr. Sushma Nandipati
3F Serene Villa, 4/250 Puliyambedu main road, Gopasanallur, Chennai – 600056 Tamilnadu , INDIA
Ms. Kaviya .C
B.Sc Cardiac Perfusion Technology Cardiothoracic an d vascular surgery department Sree Balaji Medical College and Hospital, Chrompet, Chennai , Tamilnadu , INDIA.
Dr. K. Koushik MBBS
Assistant professor in CTVS Cardiothoracic and vascular surgery department Sree Balaji Medical College and Hospital, Chrompet, Chennai , Tamilnadu, INDIA.
Mr. G. John Jude B.Sc
Tutor Clinical Perfusionist Cardiothoracic and vascular department Sree Balaji Medical College and Hospital, Chrompet, Chennai , Tamilnadu , INDIA.
Dr. S. Balachandran., M.S.,M.Ch
HOD and Professor in CTVS Cardiothoracic and vascular surgery department Sree Balaji Medical College and Hospital, Chrompet, Chennai , Tamilnadu , INDIA.