THE RELATIONSHIP BETWEEN SEXUAL DYSFUNCTION AND PSYCHIATRIC STATUS IN PREMENOPAUSAL WOMEN WITH FIBROMYALGIA
Main Article Content
Keywords
..
Abstract
Background: The purpose of this research is to investigate the relationship between mental diseases, particularly fibromyalgia in premenopausal women, and sexual dysfunction.
Objective: This study aims to compare a group of women with fibromyalgia to a control group of women without overt organic disorders to determine how well fibromyalgia predicts sexual and mental health.
Materials and Methods: The prospective study included 38 age-matched healthy women and 82 premenopausal female patients with fibromyalgia certified by the American College of Rheumatology. Patients with newly diagnosed fibromyalgia and those without a history of mental disorders or treatments that can impair sexual function were included in the study according to certain criteria. Several evaluation instruments were used, including the Female Sexual Function Index (FSFI), a questionnaire used to gauge sexual function. The State-Trait Anxiety Inventory (STAI) for measuring anxiety levels and the Beck Depression Inventory (BDI) for measuring depression levels. Additionally, the hormonal concentrations of cortisol and testosterone in serum samples were examined, and statistical analyses were performed using the Statistical Package for the Social Sciences software.
Results: When compared to the normative cut-off score of 25 (Mean = 18.76), the Fibromyalgia Group's aggregate score on the FSFI test revealed considerably higher levels of sexual dysfunction and lower levels of sexual satisfaction. The average ratings showed significant deficits in all areas of sexual function: arousal 3.87, 3.45, orgasm 3.57, pleasure 3.77, discomfort 4.14, and desire 3.35. Additionally, compared to the control group, the mean BDI and STAI for fibromyalgia patients were 27.24 and 57.85, respectively. The two groups' serum levels of cortisol, LH, FSH, testosterone, and estradiol did not significantly vary.
Conclusion: The research concludes that high rates of sexual dysfunction, as well as high rates of anxiety and sadness in premenopausal women, are associated with fibromyalgia. This supports the necessity for a multimodal approach to this condition's management that takes the psychological component into account as well.
References
2. Kalichman L. Association between fibromyalgia and sexual dysfunction in women. Clinical Rheumatology. 2009 Jan 23;28(4):365–9.
3. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Fibromyalgia [Internet]. National Institute of Arthritis and Musculoskeletal and Skin Diseases. 2017. Available from: https://www.niams.nih.gov/health-topics/fibromyalgia
4. Wolfe F, Walitt B, Perrot S, Rasker JJ, Häuser W. Fibromyalgia diagnosis and biased assessment: Sex, prevalence and bias. Sommer C, editor. PLOS ONE. 2018 Sep 13;13(9):e0203755.
5. Galvez-Sánchez CM, Duschek S, Reyes del Paso GA. Psychological impact of fibromyalgia: current perspectives. Psychology Research and Behavior Management [Internet]. 2019 Feb;Volume 12(12):117–27. Available from: https://www.dovepress.com/psychological-impact-of-fibromyalgia-current-perspectives-peer-reviewed-fulltext-article-PRBM
6. Semiz EA, Hizmetli S, Semiz M, Karadağ A, Adalı M, Tuncay MS, et al. Serum cortisol and dehydroepiandrosterone-sulfate levels after balneotherapy and physical therapy in patients with fibromyalgia. Saudi Medical Journal. 2016 May;37(5):544–50.
7. SavasKarpuz. The Effect of Frequency of Sexual Intercourse on Symptoms in Women with Fibromyalgia. SiSliEtfalHastanesi Tip Bulteni / The Medical Bulletin of Sisli Hospital [Internet]. 2024 Jan 1 [cited 2024 Oct 10];91–6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11128690/
8. Úbeda-D’Ocasar E, Jiménez Díaz-Benito V, Gallego-Sendarrubias GM, Valera-Calero JA, Vicario-Merino Á, Hervás-Pérez JP. Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis. Diagnostics. 2020 Nov 9;10(11):922.
9. Chronister BN, Gonzalez E, Lopez-Paredes D, Suarez-Torres J, Gahagan S, Martinez D, et al. Testosterone, estradiol, DHEA and cortisol about anxiety and depression scores in adolescents. Journal of Affective Disorders. 2021 Nov;294:838–46.
10. Romero-Alcalá P, Hernández-Padilla JM, Fernández-Sola C, Coín-Pérez-Carrasco M del R, Ramos-Rodríguez C, Ruiz-Fernández MD, et al. Sexuality in male partners of women with fibromyalgia syndrome: A qualitative study. Sommer C, editor. PLOS ONE. 2019 Nov 27;14(11):e0224990.
11. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. Journal of sex & marital therapy [Internet]. 2000;26(2):191–208. Available from: https://www.ncbi.nlm.nih.gov/pubmed/10782451/
12. مدیلیب [Internet]. Medilib. Ir. MediLib; 2024 [cited 2024 Oct 10]. Available from: https://medilib.ir/uptodate/show/5424
13. Cetingok S, Seker O, Cetingok H. The relationship between fibromyalgia and depression, anxiety, anxiety sensitivity, fear-avoidance beliefs, and quality of life in female patients. Medicine. 2022 Sep 30;101(39):e30868.
14. Basson R, Gilks T. Women’s sexual dysfunction associated with psychiatric disorders and their treatment. Women’s Health. 2018 Jan;14:174550651876266.
15. Yaqoob S, Yaseen M, Abdullah H, Jarullah FA, Khawaja UA. Sexual Dysfunction and Associated Anxiety and Depression in Female Hemodialysis Patients: A Cross-Sectional Study at Karachi Institute of Kidney Diseases. Cureus. 2020 Aug 31;
16. Wang YP, Gorenstein C. Assessment of depression in medical patients: A systematic review of the utility of the Beck Depression Inventory-II. Clinics. 2013 Sep 26;68(9):1274–87.
17. McBeth. The association between tender points, psychological distress, and adverse childhood experiences: a community-based study. Arthritis and rheumatism [Internet]. 2021 [cited 2024 Oct 10];42(7). Available from: https://pubmed.ncbi.nlm.nih.gov/10403267/
18. Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluß E, et al. EULAR revised recommendations for the management of fibromyalgia. Annals of the Rheumatic Diseases. 2016 Jul 4;76(2):318–28.
19. Gatchel RJ, Peng YB, Peters ML, Fuchs PN, Turk DC. The biopsychosocial approach to chronic pain: Scientific advances and future directions. Psychological Bulletin. 2007;133(4):581–624.
20. Bair MJ, Krebs EE. Fibromyalgia. Annals of Internal Medicine. 2020 Mar 3;172(5):ITC33.
21. Knowles KA, Olatunji BO. Specificity of trait anxiety in anxiety and depression: Meta-analysis of the State-Trait Anxiety Inventory. Clinical Psychology Review [Internet]. 2020 Dec 1;82(1):101928. Available from: https://www.sciencedirect.com/science/article/abs/pii/S027273582030116
22. Gómez-Hernández M, Gallego-Izquierdo T, Martínez-Merinero P, Pecos-Martín D, Ferragut-Garcías A, Hita-Contreras F, et al. Benefits of adding stretching to a moderate-intensity aerobic exercise programme in women with fibromyalgia: a randomized controlled trial. Clinical Rehabilitation. 2019 Dec 18;34(2):242–51
23. A Ismail S, E Abdel-Azim N, A Saleh M, A Mohamed A, H Yosef A, M Abbas A. A new grading system for female sexual dysfunction based on the female sexual function index in Egyptian women: a cross-sectional study. African Health Sciences [Internet]. 2021 Aug 2 [cited 2022 Aug 3];21(2):835–41. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC8568215/
24. Çay M. The Effect of Cortisol Level Increasing Due to Stress in Healthy Young Individuals on Dynamic and Static Balance Scores. Northern Clinics of Istanbul [Internet]. 2018;5(4). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371989/
25. Brajer-Luftmann B, Mardas M, Stelmach-Mardas M, Lojko D, Batura-Gabryel H, Piorunek T. Association between Anxiety, Depressive Symptoms, and Quality of Life in Patients Undergoing Diagnostic Flexible Video Bronchoscopy. International Journal of Environmental Research and Public Health. 2021 Oct 1;18(19):10374.