NASAL POLYPS PATHOPHYSIOLOGY, DIAGNOSIS, ANDEMERGING TREATMENTS

Abstract

 Background: Nasal polyps are tumour like swellings originating from the mucous membrane lining
either the nasal cavity or the paranasal sinuses and is related to chronic rhinosinusitis and asthma .
Namely, these polyps can lead to considerable NAO, hyposmia, and recurrent infection, which affect
the patients’ quality of life.
Objectives: To develop a treatment outcome assessment tool for evaluating nasosinus polyp patients
with the objective of comparing the efficacy of nasosinus polyp and emerging treatment options with
regards to polyp size and its effect towards symptoms.
Study design: A Cross sectional study.
Place and duration of study . department of ENT kabir medical college from july 2021 to dec 2021
Methods: An observational study was performed cross-sectional including 150 patients diagnosed
with nasal polyps. All of them received corticosteroids, biologics or surgical therapy. Stones’ size
change, as well as the symptom recurrence rate at the initial and after six months to the therapy were
considered on the outcomes.
Results: When analyzing the results of treatment carried out in 150 patients of the study, lower polyp
size reduction was revealed in patients who received biologic agents with the mean decrease of 50%
(p < 0. 001, SD = 7. 5). Corticosteroid group was numerically less with 35 % (p < 0. 05, SD = 6. 8)
and surgery group was 45 % less (p < 0. 001, SD = 7. 0). The global symptom rating also dropped
across all the groups and this was highly evident in the biologic using groups.
Conclusion: Recent intervention therapies especially biologic agents have received a lot of credit in
managing polyps and alleviating the symptoms. These directive findings endorse the undisputable use
and fashioning of biologics in the management of nasal polyps.