CLINICAL OUTCOME EVALUATION AND PROGNOSIS OF ICU-ADMITTED DRUG ABUSE
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Keywords
Drug abuse, ICU, mortality, mechanical ventilation, opioids, clinical outcomes
Abstract
Background: Substance abuse is a significant global issue, leading to severe health complications that often necessitate intensive care unit (ICU) admission. The prognosis of ICU-admitted drug abuse patients remains a critical area for study, given the high morbidity and mortality associated with this population.
Objectives: To evaluate the clinical outcomes and identify predictors of mortality in ICU-admitted patients with drug abuse.
Study Design and Setting: This was a prospective observational study ICU of Liaquat University of Medical and Health Sciences, Jamshoro
Methodology: Patients aged 18 years and older, diagnosed with drug abuse and admitted to the ICU, were included in the study. Data were collected on demographics, type of substance abused, clinical interventions (mechanical ventilation, renal replacement therapy), length of ICU stay, and mortality. Multivariate logistic regression was used to identify predictors of mortality..
Results: The mean age of the patients was 38.5 ± 11.2 years, with 54.8% being male. Opioid abuse was the most common (32.6%), followed by alcohol (25.2%). The mean ICU stay was 6.7 ± 3.1 days, with 45.9% of patients requiring mechanical ventilation and 20.0% needing renal replacement therapy. The overall mortality rate was 25.2%. Logistic regression did not identify any statistically significant predictors of mortality.
Conclusion: ICU admission due to drug abuse results in considerable morbidity, but no significant predictors of mortality were identified in this study. Further research is warranted to improve the prediction of outcomes in this patient population.
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Khurram Saleem
Assistant Professor, Department of Forensic Medicine, Sheikh Zayed Medical College, Rahim Yar Khan
Dr. Aisha Rasheed
Assistant Professor, Department of Forensic Medicine & Toxicology, Liaquat University of Medical and Health Sciences, Jamshoro
Nasim Irshad
Assistant professor Army Medical College Forensic Medicine Department, Rawalpindi
Qamar Zaman Phull
MBBS MPhil Assistant Professor Department of Pharmacology Bilawal Medical College LUMHS Jamshoro
Muzna Hameed Dar
Assistant professor, Department of Pharmacology, BMC, LUMHS, Jamshoro
Shahla Imran
Assistant Professor Department of forensic medicine Bilawal medical college LUMHS Jamshoro