COMPARATIVE EFFECTIVENESS OF ANTIHISTAMINE NASAL SPRAY VERSUS ORAL ANTIHISTAMINE ALLERGIC RHINITIS TREATMENT
Main Article Content
Keywords
Adverse Events, Allergic Rhinitis, Antihistamines, Ebastine, Effectiveness, Olopatadine, Symptom Relief
Abstract
Background: Allergic rhinitis (AR) is a common condition characterized by symptoms such as sneezing, nasal congestion, and itchy eyes, significantly affecting quality of life. Antihistamines, both oral and nasal, are commonly used to manage AR symptoms, but their comparative effectiveness remains underexplored.
Objectives: To compare effectiveness of antihistamine nasal spray versus oral antihistamine allergic rhinitis treatment.
Study Setting & Design: This comparative cross-sectional study was conducted at ENT Department, Shahida Islam Hospital, Lodhran from 6th October 2020 to 5th April 2021.
Methodology: Total of 140 participants aged 18 to 65, diagnosed with moderate to severe allergic rhinitis, were recruited. Group A received 10 mg of oral ebastine once daily, while Group B received olopatadine 0.6% nasal spray twice daily. Symptom severity was assessed using a validated questionnaire at baseline, two weeks, and four weeks. Data were analyzed using SPSS version 25, with statistical significance set at p < 0.05.
Results: The Both treatment groups showed significant improvement in symptoms. In Group A, symptom relief was 72.85% after 7 days and 78.57% after 14 days. In Group B, symptom relief was 67.14% after 7 days and 71.42% after 14 days. Adverse events were slightly higher in Group B, with dry mouth and drowsiness being the most common.
Conclusion: The Both Ebastine and Olopatadine effectively reduced allergic rhinitis symptoms, with Ebastine showing slightly higher effectiveness. The incidence of adverse events was comparable between the two groups.
Objectives: To compare effectiveness of antihistamine nasal spray versus oral antihistamine allergic rhinitis treatment.
Study Setting & Design: This comparative cross-sectional study was conducted at ENT Department, Shahida Islam Hospital, Lodhran from 6th October 2020 to 5th April 2021.
Methodology: Total of 140 participants aged 18 to 65, diagnosed with moderate to severe allergic rhinitis, were recruited. Group A received 10 mg of oral ebastine once daily, while Group B received olopatadine 0.6% nasal spray twice daily. Symptom severity was assessed using a validated questionnaire at baseline, two weeks, and four weeks. Data were analyzed using SPSS version 25, with statistical significance set at p < 0.05.
Results: The Both treatment groups showed significant improvement in symptoms. In Group A, symptom relief was 72.85% after 7 days and 78.57% after 14 days. In Group B, symptom relief was 67.14% after 7 days and 71.42% after 14 days. Adverse events were slightly higher in Group B, with dry mouth and drowsiness being the most common.
Conclusion: The Both Ebastine and Olopatadine effectively reduced allergic rhinitis symptoms, with Ebastine showing slightly higher effectiveness. The incidence of adverse events was comparable between the two groups.
References
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11. Gao H, Niu Y, Wang Q, Shan G, Ma C, Wang H, Hu Y, Guan K, Gu J, Wang J, Wang T. Analysis of prevalence and risk factors of adult self-reported allergic rhinitis and asthma in plain lands and hilly areas of Shenmu city, China. Frontiers in Public Health. 2022 Jan 4;9:749388.
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13. Ahmad J, Abbas N, Iftikhar M, Mujtabaghauri S, Nasir MQ. Efficacy of Antihistamine Nasal Spray Compared with Oral Antihistamine in Treatment of Allergic Rhinitis. Pakistan Journal of Medical & Health Sciences. 2023 Jun 9;17(04):539-45.
14. Shahzad J, Chaudhry S, Aslam MM, Akbar A, Shahzad MH, Chaudhry S, Aslam MM, Akbar A, Hanif M. Comparison of Fluticasone Furoate Nasal Spray Versus Combined Oral Anti-Histamine and Anti-Leukotriene Therapy in Allergic Rhinitis. Journal of Rawalpindi Medical College. 2018 Jun 30;22(2):533-39.
15. Du K, Qing H, Zheng M, Wang X, Zhang L. Intranasal antihistamine is superior to oral H1 antihistamine as an add-on therapy to intranasal corticosteroid for treating allergic rhinitis. Annals of Allergy, Asthma & Immunology. 2020 Nov 1;125(5):589-96.
16. Abdullah B, Abdul Latiff AH, Manuel AM, Mohamed Jamli F, Dalip Singh HS, Ismail IH, Jahendran J, Saniasiaya J, Keen Woo KC, Khoo PC, Singh K. Pharmacological management of allergic rhinitis: a consensus statement from the Malaysian Society of Allergy and Immunology. Journal of Asthma and Allergy. 2022 Dec 31:983-1003.
17. Srinivas CV, Subbaiah S, Chandregowda BV. Treatment of Allergic Rhinitis: A Comparative Study of Traditional Antihistamine oral Rupatidine Versus Oral Rupatidine with a Lipid Based Nasal Ointment. Indian Journal of Otolaryngology and Head & Neck Surgery. 2019 Nov;71:1699-704.
18. Singh NK, Nagpure PS, Yadav MK, Chavan S, Manpe S, Ganeshkar R. Effectiveness of Oral Antihistamines and Intranasal Steroid Spray in relieving Ocular Symptoms in Allergic Rhinitis using Total Ocular Symptom Score. An International Journal of Otorhinolaryngology Clinics. 2016 Dec 1;8(2):45-50.
19. SamantarayK, DhirR, DeshmukhS, SrivastavaP,BhagatSB, PatilS, et al. Comparative clinical assessment of mometasone furoate-azelastine hydrochloride intranasal spray (Ryaltris AZ®) with fluticasone furoate-azelastine hydrochloride intranasal spray in patients with allergic rhinitis in India. Int J Otorhinolaryngol Head Neck Surg 2023;9:637-41.
20. Yaseen MA, Piro SM. The effect of intranasal steroid in the treatment of allergic rhinitis with and without oral antihistamine (comparative study). AMJ (Advanced Medical Journal). 2022 Jun 10;6(2):183-95.
2. Naclerio R, Ansotegui IJ, Bousquet J, Canonica GW, d'Amato G, Rosario N, Pawankar R, Peden D, Bergmann KC, Bielory L, Caraballo L. International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: impact of air pollution on patients with AR: current knowledge and future strategies. World Allergy Organization Journal. 2020 Mar 1;13(3):100106.
3. Inomata T, Nakamura M, Iwagami M, Sung J, Ebihara N, Fujisawa K, Muto K, Nojiri S, Ide T, Okano M, Okumura Y. Individual characteristics and associated factors of hay fever: A large-scale mHealth study using AllerSearch. Allergology International. 2022;71(3):325-34.
4. Siddiqui ZA, Walker A, Pirwani MM, Tahiri M, Syed I. Allergic rhinitis: diagnosis and management. British journal of hospital medicine. 2022 Feb 2;83(2):1-9.
5. García-Marcos L, Asher MI, Pearce N, Ellwood E, Bissell K, Chiang CY, El Sony A, Ellwood P, Marks GB, Mortimer K, Martínez-Torres AE. The burden of asthma, hay fever and eczema in children in 25 countries: GAN Phase I study. European Respiratory Journal. 2022 Sep 1;60(3).
6. Rong CW, Salleh H, Nishio H, Lee M. The impact of increasing ambient temperature on allergic rhinitis: A systematic review and meta-analysis of observational studies. Science of The Total Environment. 2024 Oct 15;947:174348.
7. Sharma K, Akre S, Chakole S, Wanjari MB. Allergic rhinitis and treatment modalities: a review of literature. Cureus. 2022 Aug;14(8):e8679.
8. Almatroudi A, Mousa AM, Vinnakota D, Abalkhail A, Alwashmi AS, Almatroodi SA, Alhumaydhi FA, Kabir R, Mahmud I. Prevalence and associated factors of respiratory allergies in the Kingdom of Saudi Arabia: A cross-sectional investigation, September–December 2020. PLoS One. 2021 Jun 23;16(6):e0253558.
9. Dierick BJ, van der Molen T, Flokstra-de Blok BM, Muraro A, Postma MJ, Kocks JW, van Boven JF. Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy. Expert review of pharmacoeconomics & outcomes research. 2020 Sep 2;20(5):437-53.
10. Oliveira TB, Persigo AL, Ferrazza CC, Ferreira EN, Veiga AB. Prevalence of asthma, allergic rhinitis and pollinosis in a city of Brazil: a monitoring study. Allergologia et Immunopathologia. 2020 Nov 1;48(6):537-44.
11. Gao H, Niu Y, Wang Q, Shan G, Ma C, Wang H, Hu Y, Guan K, Gu J, Wang J, Wang T. Analysis of prevalence and risk factors of adult self-reported allergic rhinitis and asthma in plain lands and hilly areas of Shenmu city, China. Frontiers in Public Health. 2022 Jan 4;9:749388.
12. Tenero L, Vaia R, Ferrante G, Maule M, Venditto L, Piacentini G, Senna G, Caminati M. Diagnosis and management of allergic rhinitis in asthmatic children. Journal of asthma and allergy. 2023 Dec 31:45-57.
13. Ahmad J, Abbas N, Iftikhar M, Mujtabaghauri S, Nasir MQ. Efficacy of Antihistamine Nasal Spray Compared with Oral Antihistamine in Treatment of Allergic Rhinitis. Pakistan Journal of Medical & Health Sciences. 2023 Jun 9;17(04):539-45.
14. Shahzad J, Chaudhry S, Aslam MM, Akbar A, Shahzad MH, Chaudhry S, Aslam MM, Akbar A, Hanif M. Comparison of Fluticasone Furoate Nasal Spray Versus Combined Oral Anti-Histamine and Anti-Leukotriene Therapy in Allergic Rhinitis. Journal of Rawalpindi Medical College. 2018 Jun 30;22(2):533-39.
15. Du K, Qing H, Zheng M, Wang X, Zhang L. Intranasal antihistamine is superior to oral H1 antihistamine as an add-on therapy to intranasal corticosteroid for treating allergic rhinitis. Annals of Allergy, Asthma & Immunology. 2020 Nov 1;125(5):589-96.
16. Abdullah B, Abdul Latiff AH, Manuel AM, Mohamed Jamli F, Dalip Singh HS, Ismail IH, Jahendran J, Saniasiaya J, Keen Woo KC, Khoo PC, Singh K. Pharmacological management of allergic rhinitis: a consensus statement from the Malaysian Society of Allergy and Immunology. Journal of Asthma and Allergy. 2022 Dec 31:983-1003.
17. Srinivas CV, Subbaiah S, Chandregowda BV. Treatment of Allergic Rhinitis: A Comparative Study of Traditional Antihistamine oral Rupatidine Versus Oral Rupatidine with a Lipid Based Nasal Ointment. Indian Journal of Otolaryngology and Head & Neck Surgery. 2019 Nov;71:1699-704.
18. Singh NK, Nagpure PS, Yadav MK, Chavan S, Manpe S, Ganeshkar R. Effectiveness of Oral Antihistamines and Intranasal Steroid Spray in relieving Ocular Symptoms in Allergic Rhinitis using Total Ocular Symptom Score. An International Journal of Otorhinolaryngology Clinics. 2016 Dec 1;8(2):45-50.
19. SamantarayK, DhirR, DeshmukhS, SrivastavaP,BhagatSB, PatilS, et al. Comparative clinical assessment of mometasone furoate-azelastine hydrochloride intranasal spray (Ryaltris AZ®) with fluticasone furoate-azelastine hydrochloride intranasal spray in patients with allergic rhinitis in India. Int J Otorhinolaryngol Head Neck Surg 2023;9:637-41.
20. Yaseen MA, Piro SM. The effect of intranasal steroid in the treatment of allergic rhinitis with and without oral antihistamine (comparative study). AMJ (Advanced Medical Journal). 2022 Jun 10;6(2):183-95.
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Published
Aug 22, 2022
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How to Cite
Ashfaq Hussain Rana, Sajid Rashid Nagra, Shuman Roy, Mohammad Afzal Khaliq, Ali Husnain Sheikh, & Mujahid Ali. (2022). COMPARATIVE EFFECTIVENESS OF ANTIHISTAMINE NASAL SPRAY VERSUS ORAL ANTIHISTAMINE ALLERGIC RHINITIS TREATMENT. Journal of Population Therapeutics and Clinical Pharmacology, 29(03), 2026-2031. https://doi.org/10.53555/5wr97w64
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Author Biographies
Ashfaq Hussain Rana
Assistant Professor, ENT Department, Shahida Islam Hospital, Lodhran
Sajid Rashid Nagra
Assistant Professor, ENT Department, Rai Medical College, Sargodha
Shuman Roy
Assistant Professor ENT Department, Akhtar Saeed Medical and Dental College
Mohammad Afzal Khaliq
Associate Professor ENT Department, Makran Medical College Turbat
Ali Husnain Sheikh
Associate Professor Akhtar Saeed Medical and Dental College/Akhtar Saeed Trust Hospital Lahore
Mujahid Ali
Associate Professor ENT Department, Fatima Jinnah Medical University, Lahore
How to Cite
Ashfaq Hussain Rana, Sajid Rashid Nagra, Shuman Roy, Mohammad Afzal Khaliq, Ali Husnain Sheikh, & Mujahid Ali. (2022). COMPARATIVE EFFECTIVENESS OF ANTIHISTAMINE NASAL SPRAY VERSUS ORAL ANTIHISTAMINE ALLERGIC RHINITIS TREATMENT. Journal of Population Therapeutics and Clinical Pharmacology, 29(03), 2026-2031. https://doi.org/10.53555/5wr97w64