PREPARATION OF SOLID LIPID NANOPARTICLES (SLN) AND NANOSTRUCTURATED LIPID CARRIERS (NLC)
Main Article Content
Keywords
Abstract
The dispersion of an oil phase that contains solid and liquid lipids into an aqueous phase that contains high concentrations of surfactants and co-surfactants results in the production of solid lipid nanoparticles (SLN) and nanostructurated lipid carriers (NLC). To produce nanoparticles that are stable, it is necessary to perform a homogenization process that involves a large amount of energy and to create a surfactant shell that provides protection over the surface of the lipid particles. The purpose of this review is to provide an overview of the various production methods for SLN and NLC. There is a discussion of the operation circumstances as well as the effect of the process variables, which takes into account the lyophilization and sterilization procedures. There is also discussion on whether or not these processes are suitable for production on a large scale.
References
2. Andonova, V., & Peneva, P. (2017). Characterization methods for solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). Current pharmaceutical design, 23(43), 6630-6642.
3. Fang, J.-Y., Fang, C.-L., Liu, C.-H., & Su, Y.-H. (2008). Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). European Journal of Pharmaceutics and Biopharmaceutics, 70(2), 633-640.
4. Ganesan, P., & Narayanasamy, D. (2017). Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery. Sustainable Chemistry and Pharmacy, 6, 37-56.
5. Garcês, A., Amaral, M., Lobo, J. S., & Silva, A. C. (2018). Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: A review. European Journal of Pharmaceutical Sciences, 112, 159-167.
6. HUANG, Z. r., HUA, S. c., YANG, Y. l., & FANG, J. y. (2008). Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion. Acta Pharmacologica Sinica, 29(9), 1094-1102.
7. López-García, R., & Ganem-Rondero, A. (2015). Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC): occlusive effect and penetration enhancement ability. Journal of cosmetics, dermatological sciences and applications, 5(02), 62.
8. López, K. L., Ravasio, A., González-Aramundiz, J. V., & Zacconi, F. C. (2023). Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) prepared by microwave and ultrasound-assisted synthesis: Promising green strategies for the nanoworld. Pharmaceutics, 15(5), 1333.
9. Müller, R. H., Alexiev, U., Sinambela, P., & Keck, C. M. (2016). Nanostructured lipid carriers (NLC): the second generation of solid lipid nanoparticles. Percutaneous penetration enhancers chemical methods in penetration enhancement: Nanocarriers, 161-185.
10. Müller, R. H., Radtke, M., & Wissing, S. A. (2002). Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Advanced drug delivery reviews, 54, S131-S155.
11. Naseri, N., Valizadeh, H., & Zakeri-Milani, P. (2015). Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Advanced pharmaceutical bulletin, 5(3), 305.
12. Sakellari, G. I., Zafeiri, I., Batchelor, H., & Spyropoulos, F. (2021). Formulation design, production and characterisation of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the encapsulation of a model hydrophobic active. Food hydrocolloids for health, 1, 100024.
13. Saupe, A., Wissing, S. A., Lenk, A., Schmidt, C., & Müller, R. H. (2005). Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)–structural investigations on two different carrier systems. Bio-medical materials and engineering, 15(5), 393-402.
14. Shidhaye, S., Vaidya, R., Sutar, S., Patwardhan, A., & Kadam, V. (2008). Solid lipid nanoparticles and nanostructured lipid carriers-innovative generations of solid lipid carriers. Current drug delivery, 5(4), 324-331.
15. Thatipamula, R., Palem, C., Gannu, R., Mudragada, S., & Yamsani, M. (2011). Formulation and in vitro characterization of domperidone loaded solid lipid nanoparticles and nanostructured lipid carriers. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 19(1), 23.
16. Tiwari, R., & Pathak, K. (2011). Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: comparative analysis of characteristics, pharmacokinetics and tissue uptake. International journal of pharmaceutics, 415(1-2), 232-243.
17. Üner, M., Wissing, S., Yener, G., & Müller, R. (2005). Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for application of ascorbyl palmitate. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 60(8), 577-582.
18. Weber, S., Zimmer, A., & Pardeike, J. (2014). Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for pulmonary application: a review of the state of the art. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 7-22.
19. Yoon, G., Park, J. W., & Yoon, I.-S. (2013). Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery. Journal of Pharmaceutical Investigation, 43, 353-362.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Rabia Taj
Shaheed Benazir Bhutto Women University of Peshawar, Pakistan
Waseem Khan
Assistant Professor, Department of Metallurgical Engineering, NED University of Engineering and Technology, Pakistan
Abdul Rauf Jamali
Assistant Professor, Department of Materials Engineering, NED University of Engineering and Technology, Pakistan
Aqsa Asim
Institute of Applied Psychology, University of the Punjab
Muhammad Faisal Hassan
Student, Department of Chemistry, Thal University Bhakkar, Pakistan