ASSESSING FREQUENCY AND RISK FACTORS RESPONSIBLE FOR CUTANEOUS LEISHMANIA AMONG PATIENTS REPORTED AT THE RURAL HEALTH CENTER, MANIKHWA DISTRICT SHERANI, PAKISTAN

Main Article Content

Muhammad Imran Khan
Haiqa Khan
Hidayat Ullah
Shiza Sufian

Keywords

Cutaneous leishmaniasis, Sand fly, Frequency, Risk factors, Sherani District, Pakistan

Abstract

Background: Pakistan faces significant obstacles concerning cutaneous leishmaniasis (CL), as the disease's distribution is relatively uneven.


Aim: This study aims to determine the frequency of cutaneous leishmaniasis (CL) in the district of Sherani, in the Province of Baluchistan, Pakistan.


Methods: This study was conducted at the rural health center of District Sherani, Pakistan. About 300 patients were included in this study. Giemsa staining was used to examine tissue and blood specimens from the lesion locations under a microscope to confirm CL. SPSS (version 26) was used using a questionnaire to evaluate the demographic data and afflicted ulcer locations gathered from study participants.


Results: It was found that 73% of suspected patients were positive and 27% were negative for CL. The face (37.5%) was the most affected body part. Children under the age of 15 were highly affected. The areas with the most positive CL cases were the Union Councils of Manikhawa (29%) and Dana Sar (30%). Most of the patients (74.4%) lived in mud houses.


Conclusion: The results showed that those who live in substandard conditions are more vulnerable to infection. Thus, it is important to stress the need to modify their lifestyles, behaviors, and level of illness awareness.

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References

[1] T. Wijerathna, N. Gunathilaka, K. Gunawardena, Y. Fujii, and D. Gunasekara, “Detection of Leishmania donovani DNA within Field-Caught Phlebotomine Sand Flies (Diptera: Psychodidae) in Three Cutaneous Leishmaniasis Endemic Foci of Kurunegala District, Sri Lanka,” J Trop Med, vol. 2021, 2021, doi: 10.1155/2021/6650388.
[2] H. M. Obaid and H. A. Shareef, “Epidemiological and clinical study of leishmaniasis in Kirkuk city, Iraq,” Iraqi Journal of Science, vol. 59, no. 3, pp. 1195–1204, 2018, doi: 10.24996/IJS.2018.59.3A.7.
[3] I. Zeb, A. Ali, J. Nawab, M. Q. Khan, A. Kamil, and K. H. Tsai, “Cutaneous leishmaniasis in male schoolchildren in the upper and lower Dir districts of Khyber Pakhtunkhwa, and a review of previous record in Pakistan,” Acta Trop, vol. 209, p. 105578, 2020, doi: 10.1016/j.actatropica.2020.105578.
[4] M. Saliba et al., “Cutaneous leishmaniasis: an evolving disease with ancient roots,” Int J Dermatol, vol. 58, no. 7, pp. 834–843, Jul. 2019, doi: 10.1111/ijd.14451.
[5] W. F. Refai, N. P. Madarasingha, B. Sumanasena, S. Weerasingha, R. Fernandopulle, and N. D. Karunaweera, “Cutaneous leishmaniasis in Sri Lanka: effect on quality of life,” Int J Dermatol, vol. 57, no. 12, pp. 1442–1446, Dec. 2018, doi: 10.1111/ijd.14240.
[6] B. Kayani et al., “Cutaneous Leishmaniasis in Pakistan: a neglected disease needing one health strategy,” BMC Infect Dis, vol. 21, no. 1, Dec. 2021, doi: 10.1186/s12879-021-06327-w.
[7] M. Yohannes, Z. Abebe, and E. Boelee, “Prevalence and environmental determinants of cutaneous leishmaniasis in rural communities in Tigray, northern Ethiopia,” PLoS Negl Trop Dis, vol. 13, no. 9, 2019, doi: 10.1371/journal.pntd.0007722.
[8] L. Gradoni, “A brief introduction to leishmaniasis epidemiology,” in The Leishmaniases: Old Neglected Tropical Diseases, Springer International Publishing, 2018, pp. 1–13. doi: 10.1007/978-3-319-72386-0_1.
[9] D. Gebremichael, “Zoonotic impact and epidemiological changes of leishmaniasis in Ethiopia,” Open Vet J, vol. 8, no. 4, pp. 432–440, 2018, doi: 10.4314/ovj.v8i4.13.
[10] H. Glans et al., “Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019,” International Journal of Infectious Diseases, vol. 122, pp. 375–381, 2022, doi: 10.1016/j.ijid.2022.06.025.
[11] Y. Hashiguchi, L. V. Nieto, N. C. Villegas, E. A. Gomez, and H. Kato, “Topical Treatment of Cutaneous Leishmaniasis: A Case Treated with A Glucantime-Based Lotion Experienced in Ecuador and A Mini Review,” Archives of Medical and Clinical Research, vol. 01, no. 01, pp. 1–15, 2021, doi: 10.51941/amcr.2021.1103.
[12] H. Goto and J. A. L. Lindoso, “Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis,” Expert Review of Anti-Infective Therapy, vol. 8, no. 4. Expert Reviews Ltd., pp. 419–433, 2010. doi: 10.1586/eri.10.19.
[13] H. J. C. de Vries and H. D. Schallig, “Cutaneous Leishmaniasis: A 2022 Updated Narrative Review into Diagnosis and Management Developments,” American Journal of Clinical Dermatology, vol. 23, no. 6. Adis, pp. 823–840, Nov. 01, 2022. doi: 10.1007/s40257-022-00726-8.
[14] D. B. H. FELLAH, M. RHAJAOUI, S. OUAHABI and M. LYAGOUBI, “Occurrence of Human Cutaneous Leishmaniasis in Zouagha My Yacoub Province ( Morocco ),” Int J Agric Biol, vol. 102, pp. 197–198, 2007.
[15] A. Z. Durrani, H. Z. Durrani, N. Kamal, and N. Mehmood, “Prevalence of cutaneous leishmaniasis in humans and dogs in Pakistan,” Pak J Zool, vol. 43, no. 2, pp. 263–271, 2011.
[16] F. Anwar et al., “Outbreak and Clinical Features of Cutaneous leishmaniasis in 2019 at District Charsadda, KP, Pakistan,” Ann Rom Soc Cell Biol, vol. 25, no. 7, pp. 1583–6258, 2021.
[17] N. Tsirigotakis et al., “Chapter 7 – Reduviid Predators,” Parasit Vectors, vol. 3, no. 1, pp. 1–12, 2018.
[18] S. Mumtaz, A. H. Munir, M. Asghar, and Naheed, “Frequency and types of leishmaniasis in Khyber Pakhtunkhwa (KPK),” Journal of Medical Sciences (Peshawar), vol. 24, no. 3, pp. 136–140, 2016.
[19] A. A. Abuzaid et al., “Cutaneous Leishmaniasis in Saudi Arabia: A Comprehensive Overview,” Vector-Borne and Zoonotic Diseases, vol. 17, no. 10, pp. 673–684, 2017, doi: 10.1089/vbz.2017.2119.
[20] M. Farahmand, H. Nahrevanian, H. A. Shirazi, S. Naeimi, and Z. Farzanehnejad, “An overview of a diagnostic and epidemiologic reappraisal of cutaneous leishmaniasis in Iran,” The Brazilian Journal of Infectious Diseases, vol. 15, no. 1, pp. 17–21, 2011, doi: 10.1016/s1413-8670(11)70134-9.
[21] M. Rashid et al., “Distribution of Cutaneous Leishmaniasis By Sex, Age Groups and Residence in Year 2020 in Cutaneous Leishmaniasis Population of District D.I.Khan, Pakistan,” Gomal Journal of Medical Sciences, vol. 19, no. 1, pp. 28–34, 2021, doi: 10.46903/gjms/19.01.964.
[22] M. Yemisen, Y. Ulas, H. Celik, and N. Aksoy, “Epidemiological and clinical characteristics of 7172 patients with cutaneous leishmaniasis in Sanliurfa, between 2001 and 2008,” Int J Dermatol, vol. 51, no. 3, pp. 300–304, 2012, doi: 10.1111/j.1365-4632.2011.05059.x.
[23] I. Bennis et al., “Control of cutaneous leishmaniasis caused by Leishmania major in south-eastern Morocco,” Tropical Medicine and International Health, vol. 20, no. 10, pp. 1297–1305, 2015, doi: 10.1111/tmi.12543.
[24] N. Haouas, O. Amer, A. Ishankyty, A. Alazmi, and I. Ishankyty, “Profile and geographical distribution of reported cutaneous leishmaniasis cases in Northwestern Saudi Arabia, from 2010 to 2013,” Asian Pac J Trop Med, vol. 8, no. 4, pp. 287–291, 2015, doi: 10.1016/S1995-7645(14)60332-1.
[25] I. Sharifi et al., “Cutaneous leishmaniasis situation analysis in the Islamic Republic of Iran in preparation for an elimination plan,” Front Public Health, vol. 11, no. April, pp. 1–22, 2023, doi: 10.3389/fpubh.2023.1091709.
[26] K. Holakouie-Naieni, E. Mostafavi, A. D. Boloorani, M. Mohebali, and R. Pakzad, “Spatial modeling of cutaneous leishmaniasis in Iran from 1983 to 2013,” Acta Trop, vol. 166, pp. 67–73, 2017, doi: 10.1016/j.actatropica.2016.11.004.
[27] M. Khan, S. Ghayyur, and S. yasmin, “Distribution, clinical features, and epidemiology of cutaneous leishmaniasis: A case study of District Haripur, KPK, Pakistan,” Medical Reports, vol. 2, no. September, p. 100025, 2023, doi: 10.1016/j.hmedic.2023.100025.
[28] T. T. Amin, H. I. Al-Mohammed, F. Kaliyadan, and B. S. Mohammed, “Cutaneous leishmaniasis in Al Hassa, Saudi Arabia: Epidemiological trends from 2000 to 2010,” Asian Pac J Trop Med, vol. 6, no. 8, pp. 667–672, 2013, doi: 10.1016/S1995-7645(13)60116-9.
[29] F. Abedi-Astaneh et al., “Risk mapping and situational analysis of cutaneous leishmaniasis in an endemic area of Central Iran: A GIS-based survey,” PLoS One, vol. 11, no. 8, pp. 1–16, 2016, doi: 10.1371/journal.pone.0161317.
[30] M. A. and A. M. K. Hayat, U., Ayaz, S., “Cutaneous Leishmaniasis : Its Prevalence and Role of PCR in its Detection,” Journal of Islamabad Medical & Dental College: JIMDC, vol. 4, no. 1, pp. 15–18, 2015.
[31] M. Khosravani, M. D. Moemenbellah-Fard, M. Sharafi, and A. Rafat-Panah, “Epidemiologic profile of oriental sore caused by Leishmania parasites in a new endemic focus of cutaneous leishmaniasis, southern Iran,” Journal of Parasitic Diseases, vol. 40, no. 3, pp. 1077–1081, 2016, doi: 10.1007/s12639-014-0637-x.
[32] S. Ayaz et al., “Cutaneous leishmaniasis in Karak, Pakistan: Report of an outbreak and comparison of diagnostic techniques,” Afr J Biotechnol, vol. 10, no. 48, pp. 9908–9910, 2011, doi: 10.5897/ajb10.1987.
[33] M. Fakhar, M. Karamian, M. A. Ghatee, W. R. Taylor, H. Pazoki Ghohe, and S. A. Rasooli, “Distribution pattern of anthroponotic cutaneous leishmaniasis caused by Leishmania tropica in Western Afghanistan during 2013-2014,” Acta Trop, vol. 176, no. July, pp. 22–28, 2017, doi: 10.1016/j.actatropica.2017.07.028.
[34] I. Zeb, A. Ali, J. Nawab, M. Q. Khan, A. Kamil, and K. H. Tsai, “Cutaneous leishmaniasis in male schoolchildren in the upper and lower Dir districts of Khyber Pakhtunkhwa, and a review of previous record in Pakistan,” Acta Trop, vol. 209, no. February, p. 105578, 2020, doi: 10.1016/j.actatropica.2020.105578.
[35] M. Farahmand, H. Nahrevanian, H. A. Shirazi, S. Naeimi, and Z. Farzanehnejad, “An overview of a diagnostic and epidemiologic reappraisal of cutaneous leishmaniasis in Iran,” The Brazilian Journal of Infectious Diseases, vol. 15, no. 1, pp. 17–21, 2011, doi: 10.1016/s1413-8670(11)70134-9.

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