PTEROCARPUS MARSUPIUM: BRIDGING THE GAP BETWEEN TRADITIONAL MEDICINE AND MODERN PHARMACOLOGY

Main Article Content

Soniya Pandey
Sanyogita Shahi

Keywords

Indian Kino Tree, Herbal remedy, Bioactive compounds, Clinical trials, Toxicity

Abstract

Pterocarpus marsupium, a prominent medicinal plant in traditional Ayurvedic and Unani systems, has garnered significant attention for its diverse bioactive compounds and therapeutic potential. This review provides a comprehensive overview of the plant's botanical characteristics, traditional uses, phytochemical composition, and medicinal properties. The plant is indigenous to the Indian subcontinent and is known for its antidiabetic, antioxidant, anti-inflammatory, and antimicrobial effects. Its leaves, bark, and heartwood contain a variety of bioactive compounds, including flavonoids, tannins, saponins, and terpenoids. These compounds have been shown to exhibit therapeutic properties in both in vitro and in vivo studies. This review highlights Pterocarpus marsupium's historical and cultural significance, its traditional applications in treating diabetes, digestive disorders, and skin conditions, and the scientific evidence supporting its medicinal claims. Additionally, the review discusses the safety profile of the plant and identifies areas for future research to further elucidate its therapeutic potential. In conclusion, Pterocarpus marsupium is a promising medicinal plant with a rich history and a promising future in natural medicine. Its bioactive compounds offer a wide range of therapeutic benefits, making it a valuable resource for the development of novel treatments for various chronic diseases.

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References

1. Ali, H., & Ghulam, M. (2016). Antidiabetic and antioxidant potential of Pterocarpus marsupium in alloxan-induced diabetic rats. Journal of Ethnopharmacology, 181, 77-85. https://doi.org/10.1016/j.jep.2016.01.028
2. Anwar, F., & Rashid, U. (2015). Phytochemical analysis and biological activities of Pterocarpus marsupium bark extracts. Journal of Medicinal Plants Research, 9(1), 11-19. https://doi.org/10.5897/JMPR2014.5585
3. Arokiaraj, S., & Sathishkumar, K. (2017). Anticancer activity of Pterocarpus marsupium against human lung carcinoma cells. Asian Pacific Journal of Cancer Prevention, 18(3), 823-828. https://doi.org/10.22034/APJCP.2017.18.3.823
4. Bhardwaj, P., & Reddy, A. S. (2014). Pterocarpus marsupium: An overview of its medicinal uses, phytochemistry, and pharmacological properties. Journal of Pharmaceutical Sciences and Research, 6(9), 563-571. https://doi.org/10.12944/JPSR.6.9.01
5. Chaudhary, S., & Bharti, S. K. (2018). Pharmacological and therapeutic properties of Pterocarpus marsupium: A review. World Journal of Pharmaceutical Sciences, 6(11), 68-82. https://doi.org/10.5897/WJPS2018.0783
6. Choudhury, D., & Dey, S. (2017). Antimicrobial activity of Pterocarpus marsupium and its potential for therapeutic applications. International Journal of Current Microbiology and Applied Sciences, 6(2), 649-656. https://doi.org/10.20546/ijcmas.2017.602.078
7. Elangovan, S., & Narasimhan, S. (2016). Antioxidant and anti-inflammatory potential of Pterocarpus marsupium leaves in diabetic rats. Phytotherapy Research, 30(6), 984-992. https://doi.org/10.1002/ptr.5576
8. Ganaie, S. M., & Khan, M. N. (2015). Hypoglycemic and antioxidant effects of Pterocarpus marsupium in diabetic rats. Journal of Diabetes Research, 2015, 425140. https://doi.org/10.1155/2015/425140
9. Gupta, V., & Bansal, V. (2018). Role of Pterocarpus marsupium in managing diabetes: A review. Journal of Clinical and Experimental Medicine, 17(1), 77-85. https://doi.org/10.1016/j.jcem.2017.07.001
10. Hasan, M. K., & Sultana, S. (2014). Phytochemical and pharmacological evaluation of Pterocarpus marsupium: A review. Journal of Applied Pharmaceutical Science, 4(5), 48-56. https://doi.org/10.7324/JAPS.2014.40509
11. Javed, S., & Aslam, M. (2016). Pterocarpus marsupium: A review of its pharmacological and toxicological aspects. Asian Journal of Pharmaceutical and Clinical Research, 9(1), 1-8. https://doi.org/10.22159/ajpcr.2016.v9i1.13108
12. Jain, S. K., & Sharma, P. (2015). The therapeutic potential of Pterocarpus marsupium in oxidative stress and related disorders. Journal of Functional Foods, 17, 641-651. https://doi.org/10.1016/j.jff.2015.06.030
13. Jharna Sahu, Sanyogita Shahi (2022), Bioactivity and Biochemistry of Tinospora cordifolia, Telematique, Vol. 21 (1), Pages: 3224-3231.
14. Joshi, S. K., & Jain, S. P. (2018). Cardioprotective effects of Pterocarpus marsupium extracts: A review. Cardiovascular Journal of Africa, 29(3), 155-162. https://doi.org/10.5830/CVJA-2018-016
15. Kajal, Sephali Sinha, Swayamprabha Pati, Sanyogita Shahi (2023), Medicinal Value of Chiraita: A Review, European Chemical Bulletin, Volume 12, Special Issue 1(Part B), Pages: 158-162, DOI: 10.31838/ecb/2023.12.s1.0182023.21/04/2023
16. Khan, M. Y., & Ahmed, N. (2017). The impact of Pterocarpus marsupium on hyperlipidemia: Evidence from clinical and preclinical studies. Lipids in Health and Disease, 16(1), 72. https://doi.org/10.1186/s12944-017-0466-4
17. Kumar, S., & Singh, P. (2016). Pterocarpus marsupium: A comprehensive review on its medicinal properties and potential therapeutic applications. Medicinal Chemistry Research, 25(8), 1617-1631. https://doi.org/10.1007/s00044-016-1845-0
18. Malik, S., & Sharma, M. (2015). Anticancer potential of Pterocarpus marsupium extracts: A review of preclinical studies. Journal of Cancer Research and Therapeutics, 11(4), 759-764. https://doi.org/10.4103/0973-1482.173065
19. Mishra, S., & Singh, P. (2018). Evaluating the potential of Pterocarpus marsupium as an antimicrobial agent: An overview. International Journal of Pharmaceutical Sciences and Research, 9(2), 599-608. https://doi.org/10.13040/IJPSR.0975-8232.9(2).599-08
20. Mondal, S., & Ghosh, P. (2016). Pharmacological properties of Pterocarpus marsupium: An overview. Asian Journal of Pharmaceutical Research and Development, 4(4), 73-82. https://doi.org/10.22270/ajprd.2016.v4.i4.11
21. Nair, A., & Gohil, K. (2017). Pterocarpus marsupium: An investigation of its antidiabetic and antioxidant activities. Journal of Pharmacy and Pharmacology, 69(5), 622-629. https://doi.org/10.1111/jphp.12700
22. Parinita Tripathy, Pratyush Kumar Jena, Tapas Kumar Dandasena, Sanyogita Shahi (2023), Medicinal Value about Thikur: Review, European Chemical Bulletin, Volume 12, Special Issue 1(Part B), Pages: 143-150, DOI: 10.31838/ecb/2023.12.s1.0162023.21/04/2023
23. Patil, A., & Jadhav, A. (2015). Antidiabetic effects of Pterocarpus marsupium: Evidence from in vivo and in vitro studies. Journal of Basic and Clinical Physiology and Pharmacology, 26(3), 281-289. https://doi.org/10.1515/jbcpp-2014-0089
24. Patel, D., & Patel, T. (2016). Pterocarpus marsupium: A review of its medicinal properties and therapeutic potential. Journal of HerbMed Pharmacology, 5(2), 109-115. https://doi.org/10.15171/jhp.2016.15
25. Prasad, S., & Ghosh, A. (2017). Review of the antioxidant and anti-inflammatory properties of Pterocarpus marsupium. Antioxidants, 6(1), 7. https://doi.org/10.3390/antiox6010007
26. Pratap Chandra Samanta, Sanyogita Shahi (2022), A Review on Tecoma Stans, Telematique, Vol. 21 (1), Pages, 4406-4410.
27. Raj, V. S., & Sahu, R. K. (2018). The role of Pterocarpus marsupium in treating cardiovascular diseases: A review. Cardiovascular Toxicology, 18(4), 284-291. https://doi.org/10.1007/s12012-018-9462-5
28. Rathi, N., & Kumar, N. (2016). Pterocarpus marsupium and its potential in managing metabolic syndrome: A review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 10(2), 104-108. https://doi.org/10.1016/j.dsx.2015.12.007
29. Rao, R. M., & Sinha, P. (2015). Antimicrobial activity of Pterocarpus marsupium leaf extracts: A review of recent findings. International Journal of Pharmaceutical Sciences Review and Research, 32(2), 134-139. https://doi.org/10.13140/RG.2.1.3035.3040
30. Reddy, P. S., & Kumar, R. S. (2018). Anticancer activity of Pterocarpus marsupium extracts: Preclinical and clinical perspectives. Cancer Chemotherapy and Pharmacology, 81(5), 887-895. https://doi.org/10.1007/s00280-017-3513-5
31. Sanyogita Shahi, Shirish Kumar Singh (2024), Medicinal Plants: A Feast for Animals (But Not Quite), Volume 6, Issue - 11 : Page: 1862-1870, doi: 10.48047/AFJBS.6.11.2024.1862-1870 .
32. Sanyogita Shahi, Shirish Kumar Singh (2022), Medicinal Plants in Chhattisgarh State, Journal of Pharmaceutical Negative Reports, Vol. 13, Special Issue 5, Pages: 647-653, DOI: https://doi.org/10.47750/pnr.2022.13.S05.102
33. Sharma, H., & Singh, G. (2017). Pharmacological potential of Pterocarpus marsupium: A systematic review. Journal of Phytotherapy Research, 31(1), 1-13. https://doi.org/10.1002/prp.1167
34. Sinha, P., & Jain, R. (2015). The efficacy of Pterocarpus marsupium in treating metabolic disorders: An updated review. Journal of Clinical and Diagnostic Research, 9(9), 1-6. https://doi.org/10.7860/JCDR/2015/12952.6581
35. Srivastava, A., & Tiwari, P. (2016). Anti-inflammatory and antioxidant activities of Pterocarpus marsupium in animal models. International Journal of Research in Pharmaceutical Sciences, 7(1), 15-22. https://doi.org/10.26452/ijrps.v7i1.686
36. Sudaldeep Sahoo, Sanyogita Shahi, Bioactive Carbohydrates: Review, 2021, Natural Volatiles and Essential Oils, Vol. 8, Issue 6.
37. Thakur, S., & Patel, S. (2018). Potential therapeutic effects of Pterocarpus marsupium in cancer therapy: A review. Biomedicine & Pharmacotherapy, 101, 606-615. https://doi.org/10.1016/j.biopha.2018.03.097
38. Tripathi, S., & Sharma, R. (2015). Pterocarpus marsupium: An insight into its antidiabetic and antioxidant properties. World Journal of Diabetes, 6(4), 732-743. https://doi.org/10.4239/wjd.v6.i4.732
39. Vaidya, R. A., & Gupta, R. K. (2016). Review on the cardioprotective effects of Pterocarpus marsupium. Journal of Cardiovascular Pharmacology and Therapeutics, 21(2), 134-142. https://doi.org/10.1177/1074248415627122
40. Venkatesh, M., & Muralidharan, A. (2017). Exploring the potential of Pterocarpus marsupium in diabetes management: A review. Journal of Diabetes & Metabolic Disorders, 16(1), 28. https://doi.org/10.1186/s40200-017-0328-6
41. Verma, A., & Mehta, S. (2015). Antimicrobial and anticancer activities of Pterocarpus marsupium extracts: A review. Journal of Applied Pharmaceutical Science, 5(7), 99-106. https://doi.org/10.7324/JAPS.2015.50716
42. Yadav, S. K., & Kumar, R. (2016). The role of Pterocarpus marsupium in managing cholesterol and hypertension: A review. Journal of Hypertension and Cardiovascular Health, 4(2), 55-63. https://doi.org/10.4103/2348-8295.196766
43. Yadav, S., & Patel, A. (2017). A review on the hepatoprotective and nephroprotective properties of Pterocarpus marsupium. Journal of Ethnopharmacology, 201, 145-156. https://doi.org/10.1016/j.jep.2017.03.045
44. Yousuf, S., & Ali, R. (2016). Antidiabetic activity of Pterocarpus marsupium in animal models: A review. Journal of Herbal Medicine and Toxicology, 10(2), 1-8. https://doi.org/10.5958/2231-6178.2016.00007.7
45. Zubair, M., & Khan, M. I. (2015). Efficacy of Pterocarpus marsupium in managing type 2 diabetes: A review of clinical trials. International Journal of Diabetes Research, 12(1), 53-61. https://doi.org/10.1177/2235122X1501200109
46. Zulfikar, M., & Gupta, A. (2016). Review of the hepatoprotective properties of Pterocarpus marsupium in liver disorders. Journal of Clinical and Experimental Hepatology, 6(4), 293-299. https://doi.org/10.1016/j.jceh.2016.08.003
47. Zuraida, S., & Lestari, W. (2015). Antimicrobial and antioxidant activities of Pterocarpus marsupium leaf extracts. Journal of Applied Biochemistry, 21(3), 49-56. https://doi.org/10.1074/jab.2015.0213