A CLINICOEPIDEMIOLOGICAL STUDY OF CUTANEOUS MANIFESTATIONS IN PATIENTS WITH INTERNAL MALIGNANCY AT A TERTIARY CARE CENTRE
Main Article Content
Keywords
Herpes labialis, Herpes zoster, Leukaemia, Lymphomas, Malignancy, Paraneoplastic reactions
Abstract
Background:
The skin, as the largest organ of the body, can display changes indicative of internal malignancies. These changes, affecting the skin, hair, nails, and mucosa, may be specific or non-specific. They can signal early malignancy, the progression of malignancies, or a compromised immune system. Such manifestations may arise from various causes, including paraneoplastic reactions, skin metastasis, inflammation, infections, or genetic syndromes. This study aims to analyze the patterns of skin conditions associated with internal malignancies.
Material and methods:
Patients with internal malignancies coming to the Dermatology outpatient department or referred by Oncologists with cutaneous manifestations were recruited for this study. After obtaining written consent, a thorough mucocutaneous examination and investigations for malignancies were done. Demographic data was collected, and the frequency and percentage of cutaneous manifestations associated with internal malignancies were calculated.
Results:
Among the 3,741 patients with internal malignancy, 1.47% (55) exhibited cutaneous manifestations. The age of these patients ranged from 3 to 75 years, with a mean age of 46.34 years. Of the 55 patients showing cutaneous manifestations, 54.55% were males and 45.45% were females. Overall, the most common malignancies observed in patients with cutaneous lesions were leukaemias and lymphomas, which accounted for about 34.54% (19 patients). Herpes zoster was the most common dermatosis, observed in 25.45% (14 patients), followed by Herpes labialis in 9.09% (5 patients).
Conclusion:
The study yielded clinically significant insights into specific and non-specific skin manifestations associated with internal malignancies. By understanding these dermatological associations, medical practitioners can enhance their diagnostic accuracy and tailor treatment strategies more effectively.
Keywords: Herpes labialis, Herpes zoster, Leukaemia, Lymphomas, Malignancy, Paraneoplastic reactions
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Dr. Meet Patel
Resident, Dept. of Dermatology, Venereology and Leprology, Mahatma Gandhi Medical College and Research Institute, Jaipur, Rajasthan, India
Dr. Manisha Nijhawan
Professor and Head, Dept. of Dermatology, Venereology and Leprology, Mahatma Gandhi Medical College and Research Institute, Jaipur, Rajasthan, India
Dr. Arvind Verma
Professor and Head, Dept. of Dermatology, Venereology and Leprology, Jaipur National University, Jaipur, Rajasthan, India
Dr. Sankalp Awasthi
Professor, Dept. of Dermatology, Venereology and Leprology, Mahatma Gandhi Medical College and Research Institute, Jaipur, Rajasthan, India