EFFECTIVENESS OF ATORVASTATIN & ITS COMBINATION WITH MORINGA OLEIFERA IN DIABETIC HYPERLIPIDEMIC RATS
Main Article Content
Keywords
Diabetes mellitus, Hyperlipidemia, Moringa oleifera, Atorvastatin
Abstract
Diabetes mellitus is a metabolic disease due to lessened secretion of insulin from beta cells of the pancreas resulting in abnormal biotransformation of proteins, fats, and carbohydrates. To assess the advantageous outcome of Atorvastatin and its combination with Moringa oleifera in Wistar rats suffering from diabetes mellitus & hyperlipidemia. In a 42-day study, a total of twenty-four Wistar rats were placed in four groups, and in each group, there were six rats. The Control group (Non-Diabetic, Non-Hyperlipidemic) was Group 1, the Control group (Untreated Diabetic & Hyperlipidemic) was Group 2, the Diabetic & Hyperlipidemic group treated with Atorvastatin was Group 3 while the Diabetic & Hyperlipidemic group treated with Atorvastatin & Moringa oleifera in combination was Group-4. In regulating hyperglycemia & hyperlipidemia, combination therapy of Atorvastatin & Moringa oleifera proves a better option. This sums up the evolvement of add-on therapy in managing diabetes mellitus & hyperlipidemia.
References
2. Diabetes mellitus history- from ancient to modern times. Available at http:// science.jrank.org/pages/2044/Diabetes-Mellitus.html. (accessed on 22nd July,2011).
3. Maitra A, Abbas AK. Endocrine system. In: Kumar V, Fausto N, Abbas AK (eds). Robbins and Cotran Pathologic basis of disease (7th ed) 2005. Philadelphia, Saunders; 1156-226.
4. Ripsin CM, Kang H, Urban RJ. Management of blood glucose in type 2 diabetes mellitus. Am Fam Physician Jan 2009; 79:29-36.
5. Maryam Munawar, Shoaib Asif, Haroon Habib, et al. Outlook on anti-hyperlipidemic outcome of Moringa oleifera in relationship with Statins. International Journal of Biology, Pharmacy & Applied Sciences (IJBPAS) June 2019; 8:1165-76.
6. Walley AJ, Blakemore AI, Froguel P. Genetics of obesity and the prediction of risk for health. Hum Mol Genet Oct 2006; 15:124-30.
7. American Diabetes Association. 8. Pharmacologic approaches to glycemic treatment. Diabetes Care. 2017; 40:64-74.
8. Thomas S. Medications that Lower Cholesterol. Journal of Lipid Research. 2003; 33: 79-82.
9. Keskin C, Özen HC, Toker Z, et al. Determination of in vitro antioxidant and antimicrobial properties of shoot and root extracts of Astragalus diphtherites FENZL var. diphtherites and Astragalus gymnalopecias RECH. FIL. obtained by different solvents. Kahramanmaras Sutcu Imam University Journal of Natural Sciences. 2018; 21:157-66.
10. Mohamed-Hesham Daba, Ahlam Elmasry, A. El-karef. Effect of Moringa oleifera with and without metformin on an experimental model of metabolic syndrome in rats. Int’l J. of Adv. Res. 2015;3(10):1624-32.
11. Popoola, J.O., Obembe, O.O. Local knowledge, use pattern and geographical distribution of Moringa oleifera Lam. (Moringaceae) in Nigeria. J. Ethnopharmacol. 2013; 150: 682–91.
12. Anwar, F., Latif, S., Ashraf, M., et al. Moringa oleifera: A food plant with multiple medicinal uses. Phyther. Res. 2007; 21:17–25.
13. Sage, AP, Lu J, Atti E, et al. Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids. J. Bone Miner Res. 2011; 26: 1197-206.
14. Freeman DJ, Norrie J, Sattar N et al. Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study. Circulation 2001; 103:357-362.
15. N. Sriram, Rajaneeekar. D, Kameshwaran. S et al. Antihyperlipidemic activity of flower extract of Tecoma stans against dexamethasone-induced hyperlipidemia in rats. IJAMSCR. 2020; 8(3): ISSN: 2347-6567
16. Nagmoti DM, Kothavade PS, Bulani VD et al. Antidiabetic and antihyperlipidemic activity of Pithecellobium dulce (Roxb.) Benth seeds extract in streptozotocin-induced diabetic rats. Eur J Integr Med 2015; 7:263e73.
17. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983 Jun; 6(2):109-110. doi: 10.1016/0304-3959(83)90201-4. PMID: 6877845.
18. Al-Bayyari N, Saadeh N, Hailat R, Al-Zeidaneen S. Assessment of Atorvastatin effect on body weight and blood glucose levels among Diabetic and non-Diabetic patients. Rom J Diabetes Nutr Metab Dis. 2017; 24(3):255-262. doi: 10.1515/rjdnmd-2017-0031
19. Koh KK, Quon MJ, Han SH, Lee Y, Kim SJ, Shin EK. Atorvastatin causes insulin reistance and increases ambient glycemia in hypercholesterolemic patients. J Am Coll Cardiol. 2010 Mar 23;55(12):1209-1216. doi: 10.1016/j.jacc.2009.10.053. PMID: 20298928; PMCID: PMC3016087
20. Oyedepo T.A, Babarinde S.O, Ajayeoba T.A. Evaluation of Anti-hyperlipidemic Effect of queous Leaves Extract of Moringa oleifera in Alloxan Induced Diabetic Rats. Int’l J of Biochem Research & Review 2013;3(3):162-170.
21. Liu P-Y, Lin L-Y, Lin H-J, Hsia C-H, Hung Y-R, et al. Pitavastatin and Atorvastatin Double-Blind Randomized ComPArative Study among HiGh-Risk Patients, Including ThOse with Type 2 Diabetes Mellitus, in Taiwan (PAPAGO-T Study). PLoS ONE. 2013; 8(10): e76298. doi:10.1371/journal.pone. 0076298. ISSN: 1932-6203
22. Kunj M., Keshri USP., Kumar C., Rana R., Kapoor S., Kumar A. Therapeutic Benefits of Mthanolic Extract of Moringa oleifera Leaf Extract in Dyslipidemia: Observational Comparative Follow up Study. Sch Acad J Biosci, Dec, 2020; 8(12): 417-422 ISSN 2347-9515 (Print) | ISSN 2321-6883 (Online) https://saspublishers.com
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Sana Imran
Department of Pharmacology, Jinnah Sindh Medical University, Karachi, Pakistan.
Syeda Afroz
Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
Tahira Mujtaba
College of Health & Life Sciences, Aston University, Birmingham UK.
Syeda Noor
Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
Sumaira Khadim
Iqra University, Karachi, Pakistan.
Saroj Fatima
Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan
Muhammad Sair
Department of Pharmacology, M Islam Medical College, Gujranwala.
Azmat Ara
Department of Pharmaceutics, University of Karachi, Karachi, Pakistan.