CLINICAL CHARACTERISTICS AND LABORATORY PARAMETERS IN DENGUE HEMORRHAGIC FEVER
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Keywords
CBC, Dengue, Antioxidants, Patients
Abstract
Introduction: Dengue is an infection caused by Dengue virus which transmitted by the bite of an infected mosquito.
Objectives: The main objective of the study is to find the clinical characteristics and laboratory parameters in Dengue hemorrhagic fever among local population of Pakistan.
Material and methods: This cross sectional study was conducted in RYK Teaching Hospital Rahim Yar Khan Pakistan. The data was collected from 200 patients of both genders. Clinical data was collected from medical records and compared between the dengue and control groups included demographic data, clinical presentations and all parameters from the CBC.
Results: The results indicate a significant reduction in T-SOD activity in the serum of infected patients (220.15 ± 34.50 U/ml.mg) compared to controls (310.45 ± 39.20 U/ml.mg) (p<0.05), suggesting increased oxidative stress during dengue infection. Additionally, MDA levels, a marker of lipid peroxidation, were significantly elevated in infected patients (6.12 ± 1.35 nmol/ml.mg) compared to controls (3.98 ± 0.40 nmol/ml.mg) (p<0.05), further highlighting oxidative damage. Conclusion: It is concluded that dengue infection significantly alters oxidative stress markers and hematological parameters, leading to reduced SOD and CAT activity, elevated MDA levels, and a decreased GSSG/GSH ratio in both serum and liver. These changes reflect the oxidative damage and systemic stress associated with the disease, emphasizing the need for early intervention to mitigate these effects.
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Talha Tariq
Medical Officer Internal Medicine, RYK Teaching Hospital, Rahim Yar Khan, Pakistan
Aizaz Ali Khan
Postgraduate Trainee, Department of Paediatric Medicine, Dr Ziauddin Hospital, Karachi Pakistan
Noor Ul Amin
Postgraduate Trainee, Department of Paediatric Medicine, Dr Ziauddin Hospital, Karachi Pakistan
Emaan Saeed
House Officer, Department of Paediatric Medicine, Dr Ziauddin Hospital, Karachi Pakistan
Alisha Saleem
House Officer, Department of Paediatric Medicine, Dr Ziauddin Hospital, Karachi Pakistan
Amna Khalid
House Officer, Department of Cardiology, Mayo Hospital, Lahore Pakistan
Syeda Wajiha Rehan
Dow University of Health Sciences, Karachi Pakistan
Hafiza Sidra
Medical Doctor Internal Medicine, University of Health Sciences, Lahore Pakistan