SEASONAL VARIATION AND CLINICAL IMPACT OF ROTAVIRUS AND CO-INFECTING ENTERIC PATHOGENS IN CHILDHOOD DIARRHEA: INSIGHTS FROM A TERTIARY CARE HOSPITAL IN INDORE, MADHYA PRADESH
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Abstract
Background
Diarrhea remains a leading cause of morbidity and mortality among children under five years of age, especially in developing countries. Rotavirus is a predominant etiological agent, often associated with co-infections from other enteric pathogens, complicating clinical outcomes. This study evaluates the seasonal variation and clinical impact of rotavirus and co-infecting enteric pathogens in childhood diarrhea cases at a tertiary care hospital in Indore, Madhya Pradesh.
Methods
A prospective observational study was conducted over 12 months, enrolling children under five presenting with acute diarrhea. Stool samples were collected and tested for rotavirus using enzyme-linked immunosorbent assay (ELISA). Additional enteric pathogens were identified using polymerase chain reaction (PCR) and culture methods. Data on clinical symptoms, treatment outcomes, and seasonal distribution were analyzed.
Results
Of the 500 children enrolled, 40% tested positive for rotavirus. Co-infections were observed in 35% of the rotavirus-positive cases, with enteric pathogens such as Escherichia coli, Shigella spp., and Giardia lamblia being the most common. A significant seasonal variation was noted, with peak incidence during the winter months (November-February). Children with co-infections had more severe clinical symptoms and longer hospital stays compared to those with rotavirus mono-infection.
Conclusion Rotavirus remains a significant cause of childhood diarrhea in Indore, with a pronounced seasonal pattern. Co-infections with other enteric pathogens exacerbate disease severity, highlighting the need for comprehensive diagnostic and therapeutic approaches in managing childhood diarrhea.
References
2. Santos, N., & Hoshino, Y. (2005). Global Distribution of Rotavirus Serotypes/Genotypes and Its Implication for the Development and Implementation of an Effective Rotavirus Vaccine. Reviews in Medical Virology, 15(1), 29-56.
3. Parashar, U.D., Hummelman, E.G., Bresee, J.S., Miller, M.A., & Glass, R.I. (2003). Global Illness and Deaths Caused by Rotavirus Disease in Children. Emerging Infectious Diseases, 9(5), 565-572.
4. Dennehy, P.H. (2008). Rotavirus Vaccines: An Overview. Clinical Microbiology Reviews, 21(1), 198-208.
5. Ramani, S., & Kang, G. (2007). Burden of Disease & Molecular Epidemiology of Group A Rotavirus Infections in India. Indian Journal of Medical Research, 125(5), 619-632.
6. Troeger, C., Blacker, B.F., Khalil, I.A., Rao, P.C., Cao, J., Zimsen, S.R.M., et al. (2018). Estimates of the Global, Regional, and National Morbidity, Mortality, and Aetiologies of Diarrhoea in 195 Countries: A Systematic Analysis for the Global Burden of Disease Study 2016. The Lancet Infectious Diseases, 18(11), 1211-1228.
7. Das, S., Jayaraman, A., Kumar, P., & Ganguly, S. (2018). Co-infections with Bacterial and Parasitic Enteropathogens in Children with Rotavirus Diarrhea in Kolkata, India. Journal of Clinical Virology, 105, 3-7.
8. Sarker, S.A., Sultana, S., Fuchs, G.J., Alam, N.H., Azim, T., & Hossain, I. (2001). Co-infections with Rotavirus, Shigella, and Enterotoxigenic Escherichia coli in Diarrheal Children in Bangladesh. Journal of Clinical Microbiology, 39(9), 3349-3351.
9. O'Ryan, M., Prado, V., & Pickering, L.K. (2005). A Millennium Update on Pediatric Diarrhea. Infectious Disease Clinics of North America, 19(3), 589-617.
10. Fischer Walker, C.L., Perin, J., Aryee, M.J., Boschi-Pinto, C., & Black, R.E. (2012). Diarrhea Incidence in Low- and Middle-Income Countries in 1990 and 2010: A Systematic Review. BMC Public Health, 12, 220.
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Mr. Ankur Vashishtha
P.hd, Scholar, Department of Microbiology, Index Medical College, Malwanchal University, Indore, Madhya Pradesh, India.
Dr. Madhurendra Singh Rajput
Professor, Department of Microbiology, Index Medical College, Malwanchal University, Indore, Madhya Pradesh, India
Dr. Madhurendra Singh Rajput
Professor, Department of Microbiology, Index Medical College, Malwanchal University, Indore, Madhya Pradesh, India
Mr. Gautam Panwar
P.hd, Scholar, Department of Microbiology, Index Medical College, Malwanchal University, Indore, Madhya Pradesh, India
Dr. Navdeep
Associate Professor, Department of Microbiology, Amaltas Institute of medical Sciences, Dewas, Madhya Pradesh, India.
Mrs. Prigya Sharma
P.hd Scholar, Department of Biotechnology, Sharda University, Greater Noida, Uttar Pradesh, India.