IN VIVO AND IN VITRO SINGLE AND SYNERGETIC EFFECTS OF FOENICULUM VULGARE, CICHORIUM INTYBUS AND SOLANUMN NIGRUM ON HEPATOPROTECTIVE AND ANTIOXIDANT HOMEOSTASIS

Main Article Content

Farhan Asad
Muhammad Akram
Abid Rashid
Riaz Ur Rehman
Sultan Ayaz

Keywords

Foeniculum vulgare, Solanum nigrum, Cichorium intybus, herbal medicine, conventional

Abstract

Abstract


The foundation of holistic medicine, which is quickly gaining traction globally and steadily establishing itself in significant healthcare systems, is herbal medicine. Medicinal plants or traditional Indian medicines are a vital source for novel pharmaceuticals. The Apiaceae family plant Foeniculum vulgare, commonly referred to as fennel, has a number of health advantages, including lowering blood pressure, decreasing water retention, enhancing vision, and easing the symptoms of acne, constipation, arthritis, coughing, gingival sores, and more.A member of the Solanaceae family, Solanum nigrum, often known as Makoh, is used to cure a range of illnesses. It is a useful herbal remedy for fever, discomfort, and mouth ulcers. It is also an effective treatment for asthma. It is also the primary component of a lot of prepared medications. It cures a range of liver issues, is helpful in treating urinary tract infections, and possesses strong hepatoprotective and anti-inflammatory qualities. The absorbance at 517 nm was then measured. A low reaction mixture absorbance indicates a high amount of radical scavenging activity.The antioxidant activity of ascorbic acid was also investigated as a point of reference. The solution without any plant extract was used as a control. Each test was administered three times.

Abstract 74 | Pdf Downloads 32

References

1. Ahmad, I., Aqil, F., Ahmad, F., &Owais, M. (2006). Herbal medicines: prospects and constraints. Modern phytomedicine: turning medicinal plants into drugs, 59-77.
2. Ak, T., &Gülçin, I. (2008). Antioxidant and radical scavenging properties of curcumin. Chemico-biological interactions, 174(1), 27-37.
3. Alamgir, A. N. M., &Alamgir, A. N. M. (2018). Vitamins, nutraceuticals, food additives, enzymes, anesthetic aids, and cosmetics. Therapeutic Use of Medicinal Plants and their Extracts: Volume 2: Phytochemistry and Bioactive Compounds, 407-534.
4. Bent, S. (2008). Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center. Journal of general internal medicine, 23, 854-859.
5. Benzie, I. F., & Strain, J. J. (1999). [2] Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. In Methods in enzymology (Vol. 299, pp. 15-27). Academic press.
6. Chanda, S., & Dave, R. (2009). In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: An overview. African Journal of Microbiology Research, 3(13), 981-996.
7. Das, S., Vasudeva, N., & Sharma, S. (2016). Cichoriumintybus: A concise report on its ethnomedicinal, botanical, and phytopharmacological aspects. Drug Development and Therapeutics, 7(1), 1-1.
8. Edeoga, H. O., Okwu, D. E., &Mbaebie, B. O. (2005). Phytochemical constituents of some Nigerian medicinal plants. African journal of biotechnology, 4(7), 685-688.
9. Ekor, M. (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in pharmacology, 4, 177.
10. Fathi, M., Mozafari, M. R., &Mohebbi, M. (2012). Nanoencapsulation of food ingredients using lipid based delivery systems. Trends in food science & technology, 23(1), 13-27.
11. Francoz, E., Ranocha, P., Nguyen-Kim, H., Jamet, E., Burlat, V., &Dunand, C. (2015). Roles of cell wall peroxidases in plant development. Phytochemistry, 112, 15-21.
12. Harborne, L. R., Sattar, N., Norman, J. E., & Fleming, R. (2005). Metformin and weight loss in obese women with polycystic ovary syndrome: comparison of doses. The Journal of Clinical Endocrinology & Metabolism, 90(8), 4593-4598.
13. Howes, M. J. R., Quave, C. L., Collemare, J., Tatsis, E. C., Twilley, D., Lulekal, E., ... &NicLughadha, E. (2020). Molecules from nature: Reconciling biodiversity conservation and global healthcare imperatives for sustainable use of medicinal plants and fungi. Plants, People, Planet, 2(5), 463-481.
14. Khan, D. A., Banerji, A., Blumenthal, K. G., Phillips, E. J., Solensky, R., White, A. A., ... & Contributors, W. (2022). Drug allergy: a 2022 practice parameter update. Journal of Allergy and Clinical Immunology, 150(6), 1333-1393.
15. Lam, P., Cheung, F., Tan, H. Y., Wang, N., Yuen, M. F., & Feng, Y. (2016). Hepatoprotective effects of Chinese medicinal herbs: a focus on anti-inflammatory and anti-oxidative activities. International Journal of Molecular Sciences, 17(4), 465.
16. Mukherjee, P. K., &Wahile, A. (2006). Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. Journal of ethnopharmacology, 103(1), 25-35.
17. Nazet, A., Sokolov, S., Sonnleitner, T., Friesen, S., & Buchner, R. (2017). Densities, refractive indices, viscosities, and conductivities of non-imidazolium ionic liquids [Et3S][TFSI],[Et2MeS][TFSI],[BuPy][TFSI],[N8881][TFA], and [P14][DCA]. Journal of Chemical & Engineering Data, 62(9), 2549-2561.
18. Nwafor, I. C., Shale, K., &Achilonu, M. C. (2017). Chemical composition and nutritive benefits of chicory (Cichoriumintybus) as an ideal complementary and/or alternative livestock feed supplement. The Scientific World Journal, 2017(1), 7343928.
19. Othman, A., Mukhtar, N. J., Ismail, N. S., & Chang, S. K. (2014). Phenolics, flavonoids content and antioxidant activities of 4 Malaysian herbal plants. International Food Research Journal, 21(2), 759.
20. Parveen, A., Ahmad, M., Parveen, B., Parveen, R., & Iqbal, M. (2022). The traditional system of Unani medicine, its origin, evolution and Indianisation: A critical appraisal. Indian Journal of Traditional Knowledge (IJTK), 21(3), 511-521.
21. Rehman, H. U., Aman, A., Silipo, A., Qader, S. A. U., Molinaro, A., & Ansari, A. (2013). Degradation of complex carbohydrate: immobilization of pectinase from Bacillus licheniformis KIBGE-IB21 using calcium alginate as a support. Food chemistry, 139(1-4), 1081-1086.
22. Saad, B., & Said, O. (2011). Greco-Arab and Islamic herbal medicine: traditional system, ethics, safety, efficacy, and regulatory issues. John Wiley & Sons.
23. Saddiqi, H. A., & Iqbal, Z. (2011). Usage and significance of fennel (Foeniculum vulgare Mill.) seeds in Eastern medicine. In Nuts and seeds in health and disease prevention (pp. 461-467). Academic Press.
24. Sanandia, J., Patel, M., &Vadia, N. (2024). Antimicrobial and Antifungal Potential of Indian Spices. Infectious Diseases, 22.
25. Seeff, L. B., Bonkovsky, H. L., Navarro, V. J., & Wang, G. (2015). Herbal products and the liver: a review of adverse effects and mechanisms. Gastroenterology, 148(3), 517-532.
26. Shahid, M., Pourrut, B., Dumat, C., Nadeem, M., Aslam, M., &Pinelli, E. (2014). Heavy-metal-induced reactive oxygen species: phytotoxicity and physicochemical changes in plants. Reviews of Environmental Contamination and Toxicology Volume 232, 1-44.
27. Sofowora, A. (1993). Recent trends in research into African medicinal plants. Journal of ethnopharmacology, 38(2-3), 197-208.
28. Sofowora, A., Ogunbodede, E., &Onayade, A. (2013). The role and place of medicinal plants in the strategies for disease prevention. African journal of traditional, complementary and alternative medicines, 10(5), 210-229.
29. Tabassum, M. (2019). A review on pharmacological and phytochemical study on Bangladeshi medicinal plants (Doctoral dissertation, Brac University).
30. Tangpao, T., Charoimek, N., Teerakitchotikan, P., Leksawasdi, N., Jantanasakulwong, K., Rachtanapun, P., ...&Sommano, S. R. (2022). Volatile organic compounds from basil essential oils: plant taxonomy, biological activities, and their applications in tropical fruit productions. Horticulturae, 8(2), 144.
31. Yasir, M., Jamil, N., Nazir, A., Kanwal, Q., Athir, N., Mustafa, R., ...& Ahmad, N. (2022). Hemolytic activity and protective potential of Lamiaceae plants seed extracts and their bioactive components profiling having potential for functional foods and nutraceutical formulations. Biocataly

Most read articles by the same author(s)

1 2 > >>