THE IMPACT OF DIABETES MELLITUS 2 IN DECLINE OF CEREBRAL FUNCTIONS
Main Article Content
Keywords
Diabetes, Cerebrum, Functions, hyperglycaemia
Abstract
Diabetes mellitus is a syndrome with disordered metabolism and inappropriate hyperglycaemia, due to either a deficiency of insulin secretion or to a combination of insulin resistance and inadequate insulin secretion to compensate. The term diabetes was originally introduced to describe the clinical symptoms associated with unduly high glucose levels. Diagnostic emphasis then shifted to the glucose levels themselves and in addition to diabetes a milder level of hyperglycaemia denoted impair glucose tolerance has been defined by the W.H.O. It affects all the systems in the body. It affects functions of cerebrum in brain. Cerebrum is important and larger part of brain. It controls major functions of body. The present study is an attempt to study impact of Diabetes mellitus 2 in decline of cerebral functions.
References
2. https://www.medicalnewstoday.com/articles/cerebrum
3. Cerebrovascular complications of diabetes: focus on stroke. Ergul A, Kelly-Cobbs A, Abdalla M, Fagan SC. Endocr Metab Immune Disord Drug Targets. 2012;12:148–158.
4. Association of diabetes mellitus and structural changes in the central nervous system in children and adolescents: a systematic review. Pourabbasi A, Tehrani-Doost M, Qavam SE, Arzaghi SM, Larijani B. J Diabetes Metab Disord. 2017;16
5. Relationship between type 2 diabetes and white matter hyperintensity: a systematic review. Wang DQ, Wang L, Wei MM, Xia XS, Tian XL, Cui XH, Li X. Front Endocrinol (Lausanne) 2020;11:595962.
6. White matter connectivity abnormalities in prediabetes and type 2 diabetes: the Maastricht study. Vergoossen LW, Schram MT, de Jong JJ, et al. Diabetes Care. 2020;43:201–208.
7. Alzheimer's disease and type 2 diabetes: a critical assessment of the shared pathological traits. Chatterjee S, Mudher A. Front Neurosci. 2018;12:383.
8. Association of diabetes mellitus and structural changes in the central nervous system in children and adolescents: a systematic review. Pourabbasi A, Tehrani-Doost M, Qavam SE, Arzaghi SM, Larijani B. J Diabetes Metab Disord. 2017;16.
9. N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease. Schuff N, Meyerhoff DJ, Mueller S, Chao L, Sacrey DT, Laxer K, Weiner MW. Adv Exp Med Biol. 2006;576:241–363.
10. Brain PET in the diagnosis of Alzheimer's disease. Marcus C, Mena E, Subramaniam RM. Clin Nucl Med. 2014;39:0.
11. Relation of hyperglycemia early in ischemic brain infarction to cerebral anatomy, metabolism, and clinical outcome. Kushner M, Nencini P, Reivich M, et al. Ann Neurol. 1990;28:129–135.