"UNVEILING THE IMPACT OF DIABETES ON BLOOD AND BIOCHEMICAL PARAMETERS: A CROSS-SECTIONAL STUDY AT LUMHS, JAMSHORO"
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Abstract
Background: Diabetes mellitus (DM) is a prevalent chronic metabolic disorder characterized by elevated blood glucose levels, which can lead to severe complications affecting multiple organ systems. In Pakistan, the prevalence of diabetes has increased significantly, necessitating comprehensive evaluation of diabetes-related complications and associated biochemical markers.
Objective: This study aimed to evaluate the effects of diabetes on various blood and biochemical parameters in patients at Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, to provide insights that can inform clinical practice and public health strategies.
Methods: A cross-sectional study was conducted involving 400 participants, divided into diabetic and non-diabetic groups. Fasting blood glucose (FBG), body mass index (BMI), waist circumference, uric acid, urea, creatinine, and complete blood count (CBC) parameters were measured. Statistical analysis, including t-tests and correlation analysis, was performed to assess the differences and relationships between groups and variables.
Results: Diabetic patients showed significantly higher levels of FBG, uric acid, and waist circumference compared to non-diabetic participants (p < 0.05). BMI and waist circumference were strongly correlated with FBG in the non-diabetic group but were weaker in the diabetic group, suggesting altered metabolic regulation in diabetic individuals. Gender differences were observed, with males having higher RBC and PCV levels, while females had higher BMI and waist circumference. Uric acid levels were also higher in males, correlating with a higher risk of cardiovascular complications.
Conclusions: The study highlights significant differences in metabolic and hematological profiles between diabetic and non-diabetic individuals, emphasizing the importance of regular monitoring of biochemical parameters for effective management of diabetes. The findings also suggest the need for gender-specific strategies in diabetes care to address the distinct metabolic challenges faced by males and females. Further research is needed to explore the mechanisms underlying these metabolic alterations and their impact on diabetes progression and complications.
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Dr Aqsa Naeem
Lecturer, Department of Physiology, LUMHS, Jamshoro
Dr Maria
Lecturer, Department of Biochemistry, LUMHS jamshoro,
Dr Beenish Ghafar
Assistant professor, Department of Biochemistry, Lumhs, Jamshoro
Dr. Sofia
Lecturer, Department of Biochemistry, Lumhs, Jamshoro
Dr Nosheen Zehra Mangi
Lecturer, Department of Biochemistry, Lumhs, Jamshoro.
Usama Feroz Daudpota
Graduate of Liaquat National Hospital and Medical College, 2021,