ASSESSMENT OF ANTIBIOTIC RESISTANCE TRENDS OF THE COMMUNITY ACQUIRED URINARY PATHOGENS
Main Article Content
Keywords
Antibiotic resistance, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, antimicrobial stewardship
Abstract
Urinary tract infections (UTIs) are primary source of infections linked to healthcare settings describing as a significant factor in the overuse and abuse of antibiotics. Antibiotic-resistant forms of UTIs have emerged, contributing to the significant public health burden. With an emphasis on gender-based variations, this study investigates the frequency and patterns of antibiotic resistance of pathogens such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterococcus faecium. This retrospective observational research was carried out between October 2023 to March 2024 in tertiary care hospital in Islamabad after getting a proper institutional ethical approval. The isolates of E. coli showed significant resistance (100%) to co-trimoxazole, ampicillin, and amoxicillin, however colistin was still effective (0% resistance). Female isolates of Klebsiella pneumoniae had strong resistance to ampicillin, amoxicillin, and augmentin (100%), as well as high resistance to ciprofloxacin (88.5%) and co-trimoxazole (91.4%). Male isolates of Pseudomonas aeruginosa exhibited whole resistance to many antibiotics, while female isolates exhibited reduced resistance (33.3%) overall, with the exception of co-trimoxazole (100%). Male isolates of Enterococcus faecium was completely resistant to a number of antibiotics, with an 83.3% resistance rate to ciprofloxacin and cefepime. Gender-specific treatment techniques are necessary due to the high rates of antibiotic resistance, which pose substantial obstacles in the treatment of illnesses. Despite Colistin effectiveness, the findings of this study underscore the vital necessity of creating novel antimicrobial medicines and strengthening antimicrobial stewardship initiatives.
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Ali Hassan
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan
Muhammad Masoom Akhtar
Department of Pharmacology, Faculty of Pharmacy, Hamdard University, Islamabad Campus, Pakistan 44000;
Ahmed Sadiq Sheikh
Faculty of Pharmacy, My University, Islamabad 44000
Hazrat Suleman
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan
Hazrat Bilal
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan
Aziz Ur Rahman
Department of Pharmacy, University of Malakand, Pakistan
Mobina Manzoor
Lahore College for Women University
Sidra Mumtaz
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan
Mohammad Younis Baloch
Department of Pharmacology, University of Balochistan, Quetta, Pakistan
Pervaiz Akhtar Shah
Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan, Allama Iqbal Campus, Lahore 54000
Tariq Javed
Margalla College of Pharmacy, Margalla Institute of Health Sciences, Rawalpindi 46000 Pakistan
Sheikh Abdur Rashid
Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan