Investigating How Specific Proteins Or Enzymes In Saliva Can Serve As Early Indicators Of Oral Cancer.
Main Article Content
Keywords
Oral cancer, saliva biomarkers, MMP-9, LDH
Abstract
Background: Specific to head and neck cancers Such diseases as oral cancer, are common, and there is poor prognosis
once the disease advances to later stages. Concentrations of certain proteins and enzymes in saliva have become the
focus for biomarker discovery; when identified timeously, this may enhance patient prognosis.
Objectives:
This is an attempt to identify high risk specific proteins / enzymes in saliva particularly for efficiency of oral cancer
biomarkers. The analysis is carried out on 150 patients, of which 100 oral cancer patients will be chosen, the other 50
will be healthy patients without signs of oral cancer.
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2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):730.
3. Zhang L, Xiao H, Wong DT. Salivary biomarkers for clinical applications. Mol Diagn Ther. 2009;13(4):245-259.
4. Malathi N, Mythili S, Vasanthi HR. Salivary diagnostics: A brief review. ISRN Dent.2014;2014:158786.
5. Nasser M, Hakeem A, Najeeb H. Matrix metalloproteinase-9 (MMP-9) as a potential biomarker in oral squamous cell carcinoma. J Oral Maxillofac Pathol. 2018;22(1):37-44.