FREQUENCY OF SYSTEMIC LUPUS ERYTHEMATOSUS AMONG PREGNANT WOMEN IN TERTIARY CARE HOSPITAL
Main Article Content
Keywords
Systemic lupus erythematosus, body mass index, parity, pregnancy
Abstract
Background: Systemic lupus erythematosus (SLE) is an idiopathic autoimmune condition which has multi-organ involvement. The risk of obstetric complications in pregnant SLE patients is significant, with an increased risk of spontaneous abortion, intrauterine fetal death, preeclampsia (PE), intrauterine growth restriction (IUGR), and preterm birth. In addition, pregnancy may be associated with disease flares requiring immunosuppressive therapy. Therefore, pregnancies in SLE patients are considered a high risk condition.
Objective: To determine the frequency of systemic lupus erythematosus among pregnant women in tertiary care hospital.
Materials and Methods: The study was conducted in the Department of Gynecology and Obstetrics at Lady Reading Hospital, Peshawar in collaboration with technical help of Karachi Metropolitan University from July 30, 2020, to January 31, 2021. This cross-sectional study included a total of 234 pregnant women who were selected consecutively. These women were then assessed for the presence of Systemic Lupus Erythematosus (SLE), aiming to determine its prevalence and potential impact on pregnancy outcomes. Comprehensive evaluations were carried out to identify SLE-related symptoms and complications, ensuring a thorough understanding of the condition within the studied population.
Results: The mean age and standard deviation of the sample was 31.1 + 5.8 years. The mean parity was 2.2 + 1.5 and the mean BMI of the sample was 26.1 + 3.6kg/m2. Family history of SLE was recorded in 32.5% of women and current SLE during pregnancy was observed in 15% of women.
Conclusion: SLE during pregnancy is fairly common in our population particularly among women who have family history of SLE. More observational studies are recommended to determine the risk factors of SLE during pregnancy and follow up longitudinal studies to determine its effect on pregnancy outcome before recommending future directions for its prevention and control
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Dr. Ambrin Gul
MBBS FCPS, MRCOG, Woman Medical Officer, Gynae Unit, District Head Quarter Hospital, Miranshah Pakistan.
Dr. Lailma Tariq
MBBS, FCPS (Gynae & Obs), Senior Registrar, Gynae and Obstetrics Unit, Mohammad Teaching hospital, Peshawar KPK Pakistan
Dr. Khawaja Fawad Parvez
MBBS, FCPS (Gyne./Obs), Assistant Professor, Obstetrics and Gynecology, Medical Teaching Institution, Lady Reading Hospital, Peshawar Pakistan.
Dr. Amna Begum
MBBS, FCPS, MCPS, Assistant Professor, Department of Obstetrics and Gynaecology
Karachi Medical & Dental College /Abbasi Shaheed Hospital, Karachi Pakistan.
Dr. Jamal Ara
FCPS (Medicine), Assistant Professor, Department of Medicine, Karachi Medical and Dental College, Karachi Pakistan.
Dr. Ameer Abbas Ali
MBBS, DCP, M. Phil (Chemical Pathology), Associate Professor Pathology, Peoples University of Medical and Health Sciences for Women (PUMHS), Nawabshah Pakistan