COMPARATIVE STUDY BETWEEN OMEGA 3 FATTY ACID INFUSION VERSUS OCTREOTIDE INFUSION IN ACUTE PANCREATITIS
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Abstract
Introduction: Acute pancreatitis (AP) is a sudden inflammation of the pancreas that can range from mild discomfort to a life-threatening condition.
Objective: The basic aim of the study is to find the comparison between omega 3 fatty acid infusion versus octreotide infusion in acute pancreatitis.
Methodology of the study: This comparative study was conducted at Department of General Surgery, S S institute of Medical Sciences Davangere Karnataka during May 2022 and Feb 2024.Data were collected from 220 patients suffering from acute pancreatitis.Patients in group A were receive a daily infusion of omega-3 fatty acids (EPA and DHA) at a dose of 1.5 g/kg body weight.The infusion was administered intravenously over a period of 4 hours for 7 consecutive days or until discharge, whichever comes first. Patients in group B were receive a daily infusion of omega-3 fatty acids (EPA and DHA) at a dose of 1.5 g/kg body weight.
Results: A total of 220 patients were enrolled in the study, with 110 patients randomly assigned to the omega-3 fatty acid infusion group and 110 patients assigned to the octreotide infusion group.At baseline, CRP levels were comparable between the two groups (150.4 ± 35.2 mg/L vs. 148.6 ± 34.8 mg/L, p=0.72). By Day 3, the omega-3 group showed a greater reduction in CRP levels (95.8 ± 28.4 mg/L) compared to the octreotide group (112.6 ± 30.1 mg/L), with a statistically significant difference (p<0.01).
Conclusion: It is concluded that omega-3 fatty acid infusion is superior to octreotide infusion in the management of acute pancreatitis. Omega-3 fatty acids significantly reduce inflammation, shorten hospital stays, and lower the incidence of complications.
References
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1. Narayanswamy T, Supreeth K, Sridhar G.Adouble blinded comparative study between omega 3 fatty acid infusion versus octreotide infusion in acute pancreatitis. Int Surg J 2020;7:3251-5.
2. Moggia, E., Koti, R., Belgaumkar, A.P., Fazio, F., Pereira, S.P., Davidson, B.R., Gurusamy, K.S., 2017. Pharmacological interventions for acute pancreatitis. Cochrane Database of Systematic Reviews, (4), pp.12-50.
3. Lankisch, P.G. and Banks, P.A., 1998. Pancreatitis. 1st ed. New York: Springer.
4. Garg, P.K. and Tondon, R.K., 2004. Survey on chronic pancreatitis in the Asia-Pacific region. Journal of Gastroenterology and Hepatology, 19, pp.998-1004.
5. Rudraiah, H.G.M., Kalke, S.V. and Desai, A., 2018. A novel treatment protocol in acute pancreatitis-the first double-blinded comparative trial of omega-3 fatty acid infusion versus octreotide. International Surgery Journal, 5, pp.4052-7.
6. Mayer, K., Meyer, S., Reinholz-Muhly, M., Maus, U., Merfels, M., Lohmeyer, J., et al., 2003. Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans. Journal of Immunology, 171, pp.4837-43.
7. Mori, T.A. and Beilin, L.J., 2004. Omega-3 fatty acids and inflammation. Current Atherosclerosis Reports, 6, pp.461-7.
8. Narayanswamy, T., Supreeth, K. and Sridhar, G., 2020. A double blinded comparative study between omega 3 fatty acid infusion versus octreotide infusion in acute pancreatitis. International Surgery Journal, 7(10), pp.3251-3255.
9. Wolbrink, D.R., Grundsell, J.R., Witteman, B., van de Poll, M., van Santvoort, H.C., Issa, E., Dennison, A., van Goor, H., Besselink, M.G., Bouwense, S.A. and Dutch Pancreatitis Study Group, 2020. Are omega-3 fatty acids safe and effective in acute pancreatitis or sepsis? A systematic review and meta-analysis. Clinical Nutrition, 39(9), pp.2686-2694.
10. Jabłońska, B. and Mrowiec, S., 2021. Nutritional support in patients with severe acute pancreatitis-current standards. Nutrients, 13(5), p.1498.
11. Griffin, O.M., 2020. Investigating the impact of body composition and nutritional intervention strategies in pancreatic cancer (Doctoral dissertation, Trinity College).
12. Murphy, A.E. and Codner, P.A., 2020. Acute pancreatitis: exploring nutrition implications. Nutrition in Clinical Practice, 35(5), pp.807-817.
13. Furbetta, N., Comandatore, A., Gianardi, D., Palmeri, M., Di Franco, G., Guadagni, S., Caprili, G., Bianchini, M., Fatucchi, L.M., Picchi, M. and Bastiani, L., 2021. Perioperative nutritional aspects in total pancreatectomy: A comprehensive review of the literature. Nutrients, 13(6), p.1765.
14. Wang, J., Xia, Y., Cao, Y., Cai, X., Jiang, S., Liao, Y., Shi, M., Luo, H. and Wang, D., 2023. Evaluating the efficacy and timing of blood purification modalities in early-stage hyperlipidemic acute pancreatitis treatment. Lipids in Health and Disease, 22(1), p.208.
15. Rykina-Tameeva, N., Samra, J.S., Sahni, S. and Mittal, A., 2023. Non-Surgical Interventions for the Prevention of Clinically Relevant Postoperative Pancreatic Fistula—A Narrative Review. Cancers, 15(24), p.5865.
16. Khatua, B., El-Kurdi, B., Patel, K., Rood, C., Noel, P., Crowell, M., Yaron, J.R., Kostenko, S., Guerra, A., Faigel, D.O. and Lowe, M., 2021. Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox. Science advances, 7(5), p.eabd6449.
17. Manoharan, J., 2022. Effectiveness of utilizing fish oil and phosphatidylcholine in ameliorating the progression of metabolic syndrome in pigs consuming a Western diet (Doctoral dissertation, Memorial University of Newfoundland).
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Dinesh L Jadhav
Professor, Department of General Surgery, S S institute of Medical Sciences Davangere Karnataka
Sagar Kannavar
Associate professor, Department of General Surgery, S S institute of Medical Sciences Davangere Karnataka
Rudramuni K
Senior resident, Department of General Surgery, S S institute of Medical Sciences Davangere Karnataka
Abhilash Aditya G
3rd PG Resident Department of General Surgery, S S institute of Medical Sciences Davangere Karnataka
Vijay Kumar H
Senior resident, Department of General Surgery, S S institute of Medical Sciences Davangere Karnataka