MATERNAL-INFANT TRANSMISSION AND MICROBIAL DYNAMICS OF GROUP B STREPTOCOCCUS: A COMPREHENSIVE STUDY IN A TERTIARY CARE SETTING
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Keywords
Group B Streptococcus, maternal-infant transmission, microbial dynamics, neonatal infection, intrapartum antibiotic prophylaxis
Abstract
Group B Streptococcus (GBS) remains a significant cause of neonatal morbidity and mortality. This study investigates the maternal-infant transmission and microbial dynamics of GBS in a tertiary care setting. We conducted a prospective study involving pregnant women and their newborns, analyzing colonization rates, transmission pathways, and the impact of intrapartum antibiotic prophylaxis (IAP). The study included 500 pregnant women at 35-37 weeks of gestation and their newborns. Maternal colonization was assessed through vaginal and rectal swabs, while neonatal colonization was determined using ear canal, nasopharynx, and rectum swabs. The overall maternal colonization rate was 24%, with significant risk factors including urinary tract infections, multiple pregnancies, and diabetes. Neonatal colonization was observed in 25% of infants born to colonized mothers, with a higher transmission rate among those whose mothers did not receive IAP. The predominant GBS serotypes were III, Ia, and V, and clonal relationships between maternal and neonatal isolates were identified, indicating vertical transmission. IAP significantly reduced neonatal colonization and infection rates. Our findings underscore the importance of effective screening and prevention strategies to mitigate the risk of GBS transmission and subsequent neonatal infections.
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Dr. Dipti Shukla
Principal, Samarpan Institute of Nursing and Paramedical Sciences, Lucknow, U.P.
Dr. Mohammad Noor Alam Khan
Senior Resident, Pediatrics, Noida International Institute of Medical Sciences ( NIIMS), Noida, U.P.
Dr. Rajdeep Paul
Assistant Professor, Microbiology, Chirayu Medical College & Hospital, Bhopal, M.P.
Dr. Kanupriya Tiwari
Senior Resident, Post graduate Department of Clinical Microbiology, King George’s Medical University, U.P.
Dr. Kuldeep Singh
Assistant Professor, Microbiology, Chirayu Medical College & Hospital, Bhopal, M.P.