COMPARATIVE STUDIES ON CONVENTIONAL AND MICROWAVE SYNTHESIS OF PARACETAMOL
Main Article Content
Keywords
Microwave synthesis, conventional synthesis, p-amino phenol, acetic anhydride
Abstract
Paracetamol (p-acetamidophen) has been synthesized using microwave irradiation and conventional heating method. Microwave technique can be used for more efficient synthesis of organic compounds as compared to conventional technique. Paracetamol has been synthesized in our laboratory by carringout a reaction between p-aminophenol and acetic anhydride inside a domestic microwave oven. Progress of the reaction monitored by TLC and product was characterized by its FTIR spectrum.
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5. Sera, L., Mcpherson, M.L., Homes, H.M., Am, J.Hosp. Palliat. Care 31(2), 2014, P. 126.
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16. Yadava R. N. And Asati. N.,International Journal of Pharmaceutical Research and Bio- Science, 3 (5), 2014, P.341-349,
17. Tudor Olariu, Lenuta-Maria Suta, Calin Popoiu, Ionut Valentin Ledeti, Georgeta Maria Simu, Germaine Savoiu-Balint, Adriana Fulias 2014 Rev. Chem, (Bucharest), 65, 633-635.
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19. Ellis F., Paracetamol, a curriculum resource, edited by Colin Osborne and Maria Peck, Royal Society of Chemistry, Burlington House, London, UK, p.1-26.
20. Whittaker, G., Sch. Sci. Rev. 85(312), 2004, p.87.
21. Loupy, A. Microwaves in Organic Synthesis, 1st edition, WileyVCH Verlag GmbH, Weinheim, 2002, p.115-116.
22. Mirafzal, G. A., SUMMER, J. M., J. Chem. Educ. 77, 2000, p.356.
23. http://www.oc-praktikum.de/.
24. Syassi B, Biugrin K and Soufiaoui M, Tetrahedron Lett. 1997 38 n8855.