COMPARISON OF DEPRESSIVE SYMPTOMS IN WOMEN HAVING PCOS WITH AND WITHOUT OBESITY
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Keywords
Polycystic Ovary Syndrome, PCOS, depressive symptoms, obesity, mental health, Patient Health Questionnaire-9, cross-sectional study, women's health, endocrine disorder
Abstract
Background: Polycystic Ovary Syndrome (PCOS) is very prevalent endocrine disorder among women, characterized by hormonal imbalances and existence of cysts on ovaries. PCOS has been associated with various physical and psychological health issues, like an increased danger of miserable symptoms. The coexistence of obesity in PCOS patients may exacerbate these symptoms, but a detailed comparison is lacking.
Aim: The primary goal of our current research is to compare occurrence and severity of depressive symptoms in women having PCOS, distinguishing between those with and without obesity. Understanding the impact of obesity on depressive symptoms in PCOS patients can help tailor more effective interventions and treatments.
Methods: Cross-sectional research was led at Riphah International Hospital Islamabad from August 2023 to March 2024, among women diagnosed with PCOS. Overall 80 participants were categorized into two groups: those with obesity (BMI ≥ 30) and those without obesity (BMI < 30). The Patient Health Questionnaire-9 (PHQ-9) was utilized to evaluate depressive symptoms. Demographic and clinical data were also collected. Statistical analyses, including t-tests and logistic regression, were employed to compare depressive symptom prevalence and severity between the two groups.
Results: An overall 80 participants were involved in our current research. The results revealed a significantly higher occurrence of depressive symptoms in PCOS patients with obesity (38%) compared to those without obesity (62%). Additionally, the severity of depressive signs, as measured by PHQ-9 scores, was significantly greater in the obese PCOS group (mean PHQ-9 score = ZZ) compared to the non-obese PCOS group (mean PHQ-9 score = WW). These differences remained statistically significant after adjusting for potential confounding variables.
Conclusion: This study provides compelling evidence of a higher prevalence and greater severity of depressive symptoms in women with PCOS who also have obesity. The findings underscore significance of addressing mental health issues in context of PCOS, particularly for those with obesity. Tailored interventions and multidisciplinary care approaches are necessary to mitigate depressive symptoms in this population.
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Raana Bibi
Clinical Fellow Obstetrics & Gynaecology, NHS, Tayside Scotland
Sadiq Jan
Associate Professor, Islamic International Medical College, Rawalpindi Pakistan
Maryam Shoaib
Associate Professor, Gynae Unit 1, Sandeman Provincial Hospital, Quetta Pakistan
Maryam Shoaib
Associate Professor, Gynae Unit 1, Sandeman Provincial Hospital, Quetta Pakistan
Saira Bano
Gynaecologist, Health Department Government of Sindh, Pakistan
Syna Pervaiz Singha
Associate Professor Anatomy, Isra University, Hyderabad Pakistan
Abroo Fatima Qazi
Associate Professor Physiology, Isra University, Hyderabad Pakistan