SERUM LIPID LEVELS AND BIOCHEMICAL CRITERION OF COPD PATIENTS IN RELATION TO SMOKING STATUS
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Keywords
Smoking status, COPD, Tobacco Consumption, Lipid Profile, Uric acid, Biochemical Parameters
Abstract
Background: Air pollution and tobacco use are known to be associated with chronic obstructive pulmonary disease (COPD), nevertheless the former is the most investigated and implicated risk factor for the condition. One of the recognized features of this long-term lung condition is that it mostly results from persistent airway inflammation. Research suggests that smoking may have an impact on lipid metabolism since it is associated with low levels of HDL cholesterol along with elevated levels of triglycerides. Being the most prevalent aqueous antioxidant, uric acid concentration is considered to indicate the body's ability to combat oxidative stress. The purpose of our study was to determine the association of smoking status with biochemical markers and lipid profiles in COPD patients.
Methods: This prospective study was conducted at D.I Khan Medical College, there were sixty COPD patients in all, and they were split into three groups based on whether they smoked or not: non-smokers, smokers, and ex-smokers. The comprehensive demographics of the enrolled cases were documented upon obtaining informed written consent. The collected data were analyzed using SPSS 24.0.
Results: Serum urea concentrations (p <0.04), smoking status (smoker, non-smoker, or ex-smoker), total serum cholesterol values (p <0.03), and the total number of packs-years for the smoker/ex-smoker categories all showed low correlations with the stages of COPD (p ˂ 0.04).
Conclusion: In addition to elevated low-density lipoprotein cholesterol (LDL-CHOL) or decreased blood uric acid levels, we found that smoking was associated with alterations in the lipid profiles of smokers and ex-smokers.
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Dr Samarah Naeem
Assistant Professor, Department of Biochemistry, HBS Medical and Dental College, Islamabad
Dr Nawab Zada Khan
Assistant Professor Department of Physiology, Mohammad College of Medicine, Peshawar
Dr Salman Khan
Associate Professor, Department of Medicine, DHQ Teaching Hospital, DI Khan
Sanam Abro
MPhil Scholar, Department of Zoology, Shah Abdul Latif University Khairpur, Sindh, Pakistan
Dr Maheen Saad
MPhil Scholar, Department of Zoology, Shah Abdul Latif University Khairpur, Sindh, Pakistan
Dr Fouzia Qadir
MBBS, M.Sc. Molecular Medicine, Associate Professor, Department of Biochemistry, North West School of Medicine, Peshawar