CENTRAL CORNEAL THICKNESS VARIATIONS FOLLOWING PHACOEMULSIFICATION: A PRE- AND POST-SURGICAL ANALYSIS

Main Article Content

Dr. Asma Shams
Dr. Narain Das
Dr. Jai Kumar
Dr. Ikramuddin Indhar
Dr. Shehla Dareshani
Dr. Mohammad Nasir Bhatti

Keywords

Cataract, phacoemulsification surgery, central corneal thickness

Abstract

Background: Cataract is the most prevalent cause of blindness worldwide, with cataract-related blindness being especially prevalent in low-income countries. However, performing surgery on a cataract that has advanced to a hypermature and cloudy state is challenging and carries a higher risk of postoperative complications, including corneal edema.


Objective: To determine the mean change in central corneal thickness after phacoemulsification surgery.


Material And Methods: This prospective observational study was conducted at the cataract clinic of Shaheed Mohtarma Benazir Bhutto Medical College Lyari and Sindh Government Lyari General Hospital, Karachi, over a six-month period from October 2018 to March 2019. Patients aged 40 to 80 years with cataracts, and no associated ocular conditions such as uveitis, glaucoma, subluxated lens, or pseudo-exfoliation (PXF) as assessed by slit lamp examination, were included. Both genders were considered. Selected cases were referred to the ward for preoperative assessment and central corneal thickness (CCT) measurement using ultrasound pachymetry, first by the principal investigator and then by a senior ophthalmologist. The final decision regarding phacoemulsification surgery was made by the senior ophthalmologist. CCT was measured again one day post-surgery and recorded on a CCT Assessment Proforma.


Results: Overall 65 patients were studies. In terms of gender, the sample of study consists of 31 males (47.6%), and 35 females (52.4%). On the central corneal thickness comparison before and after surgery, thickness was 538.2+34.16 before surgery, while after surgery it was found 578.83+29.11 with significant difference p-value 0.065.


Conclusion: Study revealed that the mean central corneal thickness increased after phacoemulsification surgery. Due to the small sample size and the limited 24-hours follow-up period, these results cannot be considered as finally conclusive and larger-scale studies are needed to confirm the findings.

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References

1. Chen X, Xu J, Chen X, Yao K. Cataract: advances in surgery and whether surgery remains the only treatment in future. Advances in Ophthalmology Practice and Research. 2021 Nov 1;1(1):100008..
2. Gupta BM, Bala A, KshitigA. World cataract research: a scientometric analysis of publications output during 2002-11" (2013). Library PhilosPract (e-journal) 2013:895.
3. Kanski JJ, Bowling B. Clinical Ophthalmology. 7th ed. Edinburgh: Elsevier Science; 2011. p. 366.
4. Gimbel, HV; Dardzhikova, AA (January 2011). "Consequences of waiting for cataract surgery.". Current Opinion in Ophthalmology. 22 (1): 28–30.
5. Lamoureux, EL; Fenwick, E; Pesudovs, K; Tan, D (January 2011). "The impact of cataract surgery on quality of life.". Current Opinion in Ophthalmology. 22 (1): 19–27.
6. Rao, GN; Khanna, R; Payal, A (January 2011). "The global burden of cataract.". Current Opinion in Ophthalmology. 22 (1): 4–9.
7. Ventura ACS, Walti R, Bohnke M. Corneal thickness and endothelial density before and after cataract surgery. Br J Ophthalmol 2001;85:18-20.
8. Salvi SM, Soong TK, Kumar BV, Hawksworth NR. Central corneal thickness changes after phacoemulsification cataract surgery. J Cataract Refract Surg 2007;33:1426-28.
9. Tao A, Chen Z, Shao Y, Wang J, Zhao Y, Lu P, et al. Phacoemulsification induced transient swelling of corneal descemet’s endothelium complex imaged with ultra-high resolution optical coherence tomography. PLoS One 2013;8(11):e80986.
10. Werblin TP. Long-term endothelial cell loss following phacoemulsification: model for evaluating endothelial damage after intraocular surgery. Refract Corneal Surg. 1993 Jan-Feb;9(1):29-35.
81. Salvi SM, Soong TK, Kumar BV, Hawksworth NR. Central corneal thickness changes after phacoemulsification cataract surgery. Journal of cataract and refractive surgery.2007; 33: 1426-8.
82. Salvi SM, Soong TK, Kumar BV, Hawksworth NR. Central corneal thickness changes after phacoemulsification cataract surgery. Journal of Cataract & Refractive Surgery. 2007 Aug 31;33(8):1426-8.
83. Aribaba OT, Adenekan OA, Onakoya AO, Rotimi-Samuel A, Olatosi JO, Musa KO, Oyefeso AO, Akinsola FB. Central corneal thickness changes following manual small incision cataract surgery. Clinical ophthalmology (Auckland, NZ). 2015;9:151.
84. Memon MN, Siddiqui SN. Changes in Central Corneal Thickness and Endothelial Cell Count Following Pediatric Cataract Surgery. Journal of the College of Physicians and Surgeons--Pakistan: JCPSP. 2015 Nov;25(11):807-10.
85. Kim MJ, Kim JH, Kim SJ. Long-term follow-up of changes in corneal endothelium after primary and secondary intraocular lens implantations in children.Greafes Arch ClinExpOphthalmol 2012; 250:925-30
86. Vasavada AR, Praveen MR, Vasavada VA. Corneal endothelial morphologic assessment in pediatric cataract surgery with intra-ocular lens implantation:a comparison of pre-operative and early postoperative specular microscopy. Am J Ophthalmol 2012; 154:259-65.
87. Nilforushan N, Falavarjani KG, Razeghinejad MR, Bakhtiari P. Cataract surgery for congenital cataract: endothelial cell characteristics, corneal thickness, and impact on intraocular pressure. JAAPOS 2007; 11:159-61.
88. Donnenfeld ED, Holland EJ, Solomon KD, et al. A multicenter randomized controlled fellow eye trial of pulse-dosed difluprednate 0.05% versus prednisolone acetate 1% in cataract surgery. Am J Ophthalmol 2011;152:609–17.e1.
89. Bolz M, Sacu S, Drexler W, Findl O. Local corneal thickness changes after small-incision cataract surgery. J Cataract Refract Surg. 2006;32(10):1667–1671.
90. Salvi SM, Soong TK, Kumar BV, Hawksworth NR. Central corneal thickness changes after phacoemulsification cataract surgery. J Cataract Refract Surg. 2007;33(8):1426–1428.
91. Ventura ACS, Wälti R, Böhnke M. Corneal thickness and endothelial density before and after cataract surgery. Br J Ophthalmol. 2001;85:18–20.
92. Gonzalez-Meijome JM, Cervino A, Yebra-Pimentel E, Parafita MA. Central and peripheral corneal thickness measurement with Orbscan II and topographical ultrasound pachymetry. J Cataract Refract Surg. 2003;29:125–132
93. Nangia V, Jonas JB, Sinha A, Matin A, Kulkarni M. Central corneal thickness and its association with ocular and general parameters in Indians: the central India eye and medical study. Ophthalmology. 2010;117(4):705–710