A META-ANALYSIS OF OPTIMAL ANTIBIOTIC TREATMENT DURATION FOR UNCOMPLICATED UTIS: ALANCING EFFICACY AND RESISTANCEnd Resistance
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Abstract
Patients typically encounter simple urinary tract infections in hospital settings. An increasing number of research studies are evaluating the most efficient approaches to treatment for uncomplicated UTIs. Comparing the outcomes of various trials is tricky because the reported results are diverse.
Objective: Identify the essential outcomes that systematic reviews of therapies and trials for the action of uncomplicated UTIs in adults must document.
Methods: We conducted a methodical investigation to identify the fundamental outcomes commonly used to assess the effectiveness of UTI therapies. We conducted a comprehensive search in the Library Cochrane of Systematic Reviews, Embase, and PubMed. A single scholar conducted an initial screening of each paper for eligibility, while the COSUTI team served as secondary reviewers. All the included papers underwent screening by two reviewers. We extracted the outcomes exactly as stated, categorizing any identical outcomes into subdomains and domains.
Results: 14 studies documented a total of 334 outcomes, with an average of 8 outcomes reported per paper. We classified the outcomes into 18 areas, most of which were associated with clinical cure results. We measured and reported a wide range of outcomes at different time points.
Conclusions: Currently, comparing the results of trials studying the simple treatment of UTIs presents a challenge due to the variation in reported outcomes. Establishing a standardized set of outcomes to record in all trials is advisable to enhance the consistency of outcome reporting.
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Izaz Ahmad
Resident Physician, Internal Medicine, Medical A Unit, Lady Reading Hospital, Peshawar
Saad
Postgraduate resident, Medical speciality group A, Lady Reading Hospital Peshawar
Haroon Ahmad
Senior House Officer, Rehman Medical Institute, Hayatabad, Peshawar
Arshad Mehmood
Resident Physician, General Medicine, Medical B ward, Hayatabad Medical Complex, Peshawar, Pakistan
Junaid Ahmad
House officer, Medicine, Hayatabad Medical Complex, Peshawar
Ameer Hamza
Resident training medical officer, Internal medicine, MTI-Mardan medical complex
Syed Aizaz Ur Rahman
Resident Physician, Medicine, Mardan Medical complex, MTI Mardan
Zubair Ahmad
Resident Physician, Internal Medicine,Medical C ward, Hayat Abad Medical Complex
Mohammad Abbas
Medical officer, pediatric oncology, shaukat khanum memorial hospital and research center, Peshawar
Muhammad Abbas
Resident Physician, Speciality Group A, Medical A ward, Hayat Abad Medical Complex, Peshawar