PROSPECTIVE COMPARATIVE STUDY OF OPEN AND MICROSCOPIC (LOUPE -4X MAGNIFICATION) VARICOCELECTOMY USING SEMINAL AND HORMONAL PARAMETERS IN GRADES II AND III VARICOCELES

Main Article Content

Dr. Subrata Bhowmick
Dr. Mrinal Kanti Debbarma

Keywords

Varicocelectomy, Semen Analysis, Hormonal Assays, Infertility

Abstract

BACKGROUND


Varicocele affects various parameters of male fertility, and varicocelectomy produces significant improvement in these parameters. Both seminal and hormonal factors are found to be affected by varicocele. Varicocele is an important cause of infertility and it is important to know the effects of varicocelectomy to prognosticate and treat varicocele effectively.


AIMS


To find out seminal & hormonal abnormalities in cases of grade II & III varicoceles and analyse the results of sub inguinal opening & microscopic (loupe) method of varicocelectomy on seminal & hormonal parameters.


METHODS


60 patients with varicocoele who underwent open and loupe 4 microscopic varicocelectomy were compared for seminal and hormonal parameters pre-operatively and post-operatively and the results were statistically analysed.


RESULTS


There were significant postoperative increases in serum Testosterone and seminal parameters like sperm concentration, count, motility and morphology. There was significant reduction of serum FSH (Follicle – Stimulating Hormone) and LH (Luteinizing Hormone) after surgery in both groups. Operative time was higher in microscopic technique and lesser complications.


CONCLUSIONS


Both open & microscopic subinguinal varicocele ligation resulted in significant improvement in all seminal parameters, testicular volume & serum testosterone with significant decrease in serum FSH & LH in patients with grade II & III varicoceles.

Abstract 47 | Pdf Downloads 29

References

1. Schneck FX, Bellinger MF. Abnormalities of the Testes and Scrotum and Their Surgical Management. In: Walsh PC, Retik AB, Vaughan ED, Wein AJ, eds. Campbell’s urology. 9th edn, Vol. 4. Philadelphia: Saunders Company 2006:3794-7.
2. Courtney TM, Mark C, Beauchamp RD, Mattox KL. Sabistan textbook of surgery. 18th edn. Saunders 2008.
3. Gat Y, Gornish M, Belenky A, Bachar GN. Evaluation of serum testosterone and free testosterone after embolisation of the internal spermatic vein for the treatment of varicocele in infertile men. Human Reprod 2004;19(10):2303-6.
4. Mori MM, Bertolla RP, Fraietta R, Ortiz V, Cedenho AP. Does varicocele grade determine extent of alteration of spermatogenesis in adolescent? Fertil Steril 2008;90(5):1769-73.
5. Zucchi A, Mearini L, Mearini E, Fioretti F, Bini V, Porena M. Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. J Androl 2006;27(4):548-51.
6. Sinescu I, Voinea S, Pieleanu S, Manea I, Gagiu C, Chibelean C, et al. Impact of subinguinal microscopic varicocelectomy on sperm quality-First Romanian experience. Romanian Journal of Urology 2010;9(4):22-6.
7. Zaheer K, Aslam S. Male infertility secondary to varicocele -a study of 75 Saudi patients. www.pjmhsonline.com
8. Zini A, Buckspan M, Berardinucci D, Jarvi K. Loss of left testicular volume in men with clinical left varicocele: correlation with grade of varicocele. Arch Androl 1998;41(1):37-41.
9. Cantatore C, Capuano P, Cobuzzi I, Vacca M, Coretti F, Falagario D, et al. Semen quality and hormonal levels in infertile patients with varicocele. Arch Ital Urol Androl 2010;82(4):291-3.
10. Su LM, Goldstein M, Schlegel PN. The effect of varicocelectomy on serum testosterone levelsin infertile men with varicocele. J Urol 1995;154(5):1752-5.
11. Cayan S, Akibay E, Bozlu M, Doruk E, Erdem E, Acar D, et al. The effect of varicocele repair on testicular volume in children & adolescents with varicoceles. J Urol 2002;108(2):731-4.
12. Gontero P, Pretti G, Fontana F, Zitella A, Marchioro G, Frea B. inguinal versus subinguinal varicocele vein ligationusing magnifying Loupe under local anaesthesis: which technique is preferable in clinical practice? Urology 2005;66(5):1075-79.
13. Kantartzi PD, Goulis DG, Bontis JN, Papadimas J. infertile men with varicocele alone & varicocele with coexistent non-obstructive azoospermia have completely different clinical, hormonal & sperm profiles. Aristotle University Medical Journal 2007;34(3):37-44.
14. Yamamoto M, Hibi H, Katsuno SA, Miyake KO. The effects of varicocelectomy on testis volumeand semen parameters in adolescents: a randomised prospective study. Nagoya J Med Sci 1995;58:127-32.
15. Pasqualotto FF, Lucon AM, de Góes PM, Sobreiro BP, Hallak J, Pasqualotto EB, et al. Semen profile, testicular volume, and hormonal levels in infertile patients with varicoceles compared with fertile men with and without varicoceles. Fertil Steril 2005;83(1):74-7.
16. Rodriques-Netto Junior N, de Castro MP. Hormonal & biochemical parameters in varicocele. Inj J Fertil 1980;25(4):311-4.
17. Zarrilli S, Paesano L, Mirone V, Finelli L, De Rosa M. Evaluation of seminal and hormonal parameters in idiopathic varicocele before and after surgical intervention. Chir Ital 1998;50(2-4):21-8.
18. Tanrikut C, Goldstein M, Rosoff JS, Lee RK, Nelson CJ, Mulhall JP. Varicocele as a risk factor for androgen deficiency and effect of repair. BJU Int 2011;108(9):1480-4.
19. Basar MM, Kisa U, Tuglu D, Kacmaz M, Basar H. the effect of varicocele on seminal plasma & serum inhibin B in adolescents & adult men. Int Urol Nephrol 2010;42(1):47-51.
20. Zucchi A, Mearini L, Mearini E, Fioretti F, Bini V, Porena M. Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. Journal of Andrology 2006;27(4):548-51.
21. Hauser R, Paz G, Botchan A, Yogev L, Yavetz H. Varicocele on sperm functions. Human Reproduction Update 2001;7(5):482-5.
22. Ku JH, Kim SW, Park K, Paick JS. Comparison of semen parameters in fertile and infertile adults with varicocele. Urology 2005;65(3):554-8.
23. Ozden C, Ozdal L, Bulut S, Guzel O, Koyuncu H, Memis A. The effect of varicocelectomy on serum inhibin level in infertile patients with varicocele. Eur Urol Suppl 2007;6(2):289.
24. Enciso M, Muriel L, Fernández JL, Goyanes V, Segrelles E, Marcos M, et al. Infertile men with varicocele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test. Journal of Andrology 2006;27(1):106-11.
25. Goldstein M, Gilbert BR, Dicker AP, Dwosh J, Gnecco C. Microsurgical inguinal varicocelectomy with delivery of the testis: an artery and lymphatic sparing technique. J Urol 1992;148(6):1808-11.
26. Al-Kandari AM, Shabaan H, Ibrahim HM, Elshebiny YH, Shokeir AA. Comparison of outcomes of different varicocelectomy techniques: open inguinal, laparoscopic, and subinguinal microscopic varicocelectomy: a randomized clinical trial. Urology 2007;69(3):417-20.