ANTI-INFLAMMATORY EFFECTS OF FATTY ACIDS AND THEIR METABOLITES IN RESOLVING INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A CROSS- OVER STUDY
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Abstract
Background: ‘Chronic Obstructive Pulmonary Disease (COPD) is marked by chronic inflammation’. Fatty acids and their derivatives have demonstrated potential anti-inflammatory effects. This study aims to explore the anti-inflammatory effects of fatty acids and their metabolites in COPD patients using a cross-over ‘study design’.
Methods: ‘A randomized, double-blind, placebo-controlled cross-over study was conducted’ at Gomal Medical College D.I Khan with 200 COPD patients. ‘Participants were randomly assigned to receive either fatty acid supplements or placebo capsules for 8 weeks, followed by a 4-week washout period, then switched to the alternate treatment’. Inflammatory markers (CRP, IL-6, TNF-α), lung function tests (FEV1, FVC), symptom scores (CAT), and quality of life (SGRQ) were evaluated at baseline and after each intervention phase.
Results: Fatty acid supplementation led to significant reductions in inflammatory markers compared to placebo. There were also improvements in symptom scores and quality of life.
Conclusion: Fatty acids and their metabolites might contribute to reducing inflammation and improving clinical outcomes in COPD patients.
References
2. Yang X, Xu D, Wen B, Ji J, Zhang Z, Li L, et al. The mediating role of exhaled breath condensate metabolites in the effect of particulate matter on pulmonary function in schoolchildren: A crossover intervention study. Science of The Total Environment. 2023;898:165517.
3. Daley-Yates P, Keppler B, Baines A, Bardsley G, Fingleton J. Metabolomic changes related to airway inflammation, asthma pathogenesis and systemic activity following inhaled fluticasone furoate/vilanterol: a randomized controlled trial. Respiratory Research. 2022;23(1):258.
4. Korpak K, Rossi M, Van Meerhaeghe A, Boudjeltia KZ, Compagnie M. Omega-3 long-chain polyunsaturated fatty acids and their bioactive lipids: A strategy to improve resistance to respiratory tract infectious diseases in the elderly? Nutrition and Healthy Aging. 2024;9(1):55-76.
5. Zaloga GP. Narrative review of n-3 polyunsaturated fatty acid supplementation upon immune functions, resolution molecules and lipid peroxidation. Nutrients. 2021;13(2):662.
6. Kayongo A, Robertson NM, Siddharthan T, Ntayi ML, Ndawula JC, Sande OJ, et al. Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease. Frontiers in immunology. 2023;13:1085551.
7. Drozd A, Kotlęga D, Nowacki P, Ciećwież S, Trochanowski T, Szczuko M. Fatty Acid Levels and Their Inflammatory Metabolites Are Associated with the Nondipping Status and Risk of Obstructive Sleep Apnea Syndrome in Stroke Patients. Biomedicines. 2022;10(9):2200.
8. Bulanda E, Wypych TP. Bypassing the gut–lung axis via microbial metabolites: implications for chronic respiratory diseases. Frontiers in Microbiology. 2022;13:857418.
9. dos Santos Simon MIS, Dalle Molle R, Silva FM, Rodrigues TW, Feldmann M, Forte GC, et al. Antioxidant micronutrients and essential fatty acids supplementation on cystic fibrosis outcomes: A systematic review. Journal of the Academy of Nutrition and Dietetics. 2020;120(6):1016-33. e1.
10. Bezerra FS, Lanzetti M, Nesi RT, Nagato AC, Silva CPe, Kennedy-Feitosa E, et al. Oxidative stress and inflammation in acute and chronic lung injuries. Antioxidants. 2023;12(3):548.
11. Pontifex M. The interactive impact of omega-3 fatty acids, APOE genotype and sex hormones on cognition: University of East Anglia; 2020.
12. Pizzini A, Lunger L, Sonnweber T, Weiss G, Tancevski I. The role of omega-3 fatty acids in the setting of coronary artery disease and COPD: a review. Nutrients. 2018;10(12):1864.
13. Fulton AS, Hill AM, Williams MT, Howe PR, Coates AM. Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review. Nutrition reviews. 2015;73(9):612-23.
14. Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DW, Bastarache L, et al. New insights into clinical and mechanistic heterogeneity of the acute respiratory distress syndrome: summary of the Aspen Lung Conference 2021. American journal of respiratory cell and molecular biology. 2022;67(3):284-308.
15. Li X, He J, Yu M, Sun J. The efficacy of vitamin D therapy for patients with COPD: A meta-analysis of randomized controlled trials. Annals of Palliative Medicine. 2020;9(2):28697-297.
16. Ding K, Jiang W, Zhan W, Xiong C, Chen J, Wang Y, et al. The therapeutic potential of quercetin for cigarette smoking–induced chronic obstructive pulmonary disease: a narrative. 2023.
17. Calder PC. n-3 PUFA and inflammation: from membrane to nucleus and from bench to bedside. Proceedings of the Nutrition Society. 2020;79(4):404-16.
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Dr Jahangir Zaib
Assistant Professor, Department of Medicine, Poonch Medical College, Rawalakot, Pakistan
Dr Maheen Saad
Assistant Professor, MBBS, Mphil, CHPE, Department of Biochemistry, Fazaia Medical College, Islamabad Pakistan
Dr Ghazan Askar
Lecturer, Department of Community Medicine and Research, Northwest School of Medicine, Peshawar Pakistan
Dr Salman Khan
Associate Professor, Department of Medicine, DHQ Teaching Hospital, Gomal Medical College, Dera Ismail Khan Pakistan
Dr Sara Askar
Medical Officer, Department of Pediatrics, Peshawar General Hospital, Peshawar Pakistan
Dr Sajid Khan
Department of Biochemistry, Jinnah Medical College University, Peshawar Pakistan
Akashnath Kivalur Ganeshanath
NHS, Wales
Saifullah Syed
Southwest Indiana University, USA