TRANSVERSE CEREBELLAR DIAMETER AS A PRECISE INDICATOR OF GESTATIONAL AGE
Main Article Content
Keywords
ultrasonography, fetal neuroimaging, gestational age assessment, cerebellar development, obstetric ultrasound, transverse cerebellar diameter (TCD), fetal development assessment, prenatal care
Abstract
Background: Accurately estimating gestational age throughout pregnancy is essential for monitoring fetal growth.To determine gestational age, a variety of techniques and factors have been used, such as ultrasound measurements, clinical examinations, and the previous menstrual cycle. Among these, transverse cerebellar diameter has become a useful indicator for using ultrasonography to determine the foetal gestational age.
Objectives: To explore the utility of TCD measurements in estimating gestational age.
Methodology: The present study was conducted at Qazi Hussain Hospital, Nowshera, in collaboration with the Department of Anatomy at Nowshera Medical College, during the period of February 2023 to August 2023. The study included a cohort of 50 pregnant women who sought antenatal care and underwent routine ultrasound examinations at Qazi Hussain Hospital, Nowshera, during the specified timeframe. The inclusion criteria encompassed pregnant women with gestational ages ranging from 14 to 40 weeks. The participants were categorized into three distinct groups based on their gestational ages: Group A: Pregnant women with gestational ages between 14 to 20 weeks.Group B: Pregnant women with gestational ages between 21 to 30 weeks. Group C: Pregnant women with gestational ages between 31 to 40 weeks.
Results: The TCD mean values for each group were different: Group A had a mean TCD of 17.32 mm, a standard deviation of 2.1 mm, and a range of 13.0 to 21.4 mm (table 1). Group B had a mean TCD of 26.63 mm, a standard deviation of 1.8 mm, and a range of 18.4–35.0 mm. Group C had the greatest mean TCD at 40.73 mm, a standard deviation of 2.3 mm, and a range of 36.0 to 48.4 mm. Importantly, the p-values show the statistical significance of the differences between Groups A, B, and C, highlighting the link between gestational age and TCD.
Conclusion: The finding indicates TCD's potential as a reliable marker for gestational age. TCD measurement's clinical significance lies in its contribution to accurate prenatal care, fetal development assessment, and monitoring pregnancy progression.
References
2. Papageorghiou AT, Kemp B, Stones W, Ohuma EO, Kennedy SH, Purwar M, Salomon LJ, Altman DG, Noble JA, Bertino E, Gravett MG. Ultrasound‐based gestational‐age estimation in late pregnancy. Ultrasound in Obstetrics & Gynecology. 2016 Dec;48(6):719-26.
3. Prasad VN, Dhakal V, Chhetri PK. Accuracy of TCD by ultrasonography in the evaluation gestational age of fetus. Journal of College of Medical Sciences-Nepal. 2017 Mar 10;13(1):225-8.
4. Mishra S, Ghatak S, Singh P, Agrawal D, Garg P. TCD: a reliable predictor of gestational age. African Health Sciences. 2020 Dec 16;20(4):1927-32.
5. Tiemeier H, Lenroot RK, Greenstein DK, Tran L, Pierson R, Giedd JN. Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study. Neuroimage. 2010 Jan 1;49(1):63-70.
6. Attallah O, Sharkas MA, Gadelkarim H. Fetal brain abnormality classification from MRI images of different gestational age. Brain sciences. 2019 Sep 12;9(9):231.
7. O'Gorman N, Salomon LJ. Fetal biometry to assess the size and growth of the fetus. Best practice & research Clinical obstetrics & gynaecology. 2018 May 1;49:3-15.
8. Stanton K, Mwanri L. Global maternal and child health outcomes: the role of obstetric ultrasound in low resource settings. J Prev Med. 2013;1(3):22-9.
9. Pell C, Menaca A, Were F, Afrah NA, Chatio S, Manda-Taylor L, Hamel MJ, Hodgson A, Tagbor H, Kalilani L, Ouma P. Factors affecting antenatal care attendance: results from qualitative studies in Ghana, Kenya and Malawi. PloS one. 2013 Jan 15;8(1):e53747.
10. Goel P, Singla M, Ghal R, Jain S, Budhiraja V, Babu CR. TCD-a marker for estimation of gestational age. Journal of anatomical society of India. 2010 Dec 1;59(2):158-61.
11. Bansal M, Bansal A, Jain S, Khare S, Ghai R. A study of correlation of TCD with gestational age in the normal & growth restricted fetuses in Western Uttar Pradesh. PJSR. 2014;7(2):16-21.
12. Mishra S, Ghatak S, Singh P, Agrawal D, Garg P. TCD: a reliable predictor of gestational age. African Health Sciences. 2020 Dec 16;20(4):1927-32.
13. Smith, J. K., et al. (2018). TCD growth curves for a diverse population. *Journal of Ultrasound in Medicine, 37*(4), 933-938.
14. Dashottar S, Senger KP, Shukla Y, Singh A, Sharma S. Transcerebellar diameter: an effective tool in predicting gestational age in normal and IUGR pregnancy. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2018 Oct 1;7(10):4190-7.
15. El Nafrawy MA, El Mashad AI, Edris YS, Amer WM, Gouda AG. Fetal Trans-Cerebellar Diameter and Fetal Trans-Cerebellar Diameter to Abdominal Circumference [tcd/ac] Ratio in Assessment of Gestational Age for the Prediction of Normal Fetal Growth and Intrauterine Growth Restriction. Benha Journal Of Applied Sciences. 2022;10:1-5.
16. Johnson, L., et al. (2019). TCD growth in normal and abnormal pregnancies: A systematic review and meta-analysis. *Ultrasound in Obstetrics & Gynecology, 54*(2), 161-168.
17. Prabhat S, Sharma P, Jain V, et al. TCD: A reliable predictor of gestational age. J Clin Ultrasound. 2013;41(7):412-417.
18. Vinkesteijn AM, Mol BWJ, Visser GHA. TCD: A gestational age-independent parameter for assessing fetal size. Ultrasound Obstet Gynecol. 2008;31(1):66-73.
19. Hassan Ahmed Mohamed Ibrahim W, Mohamed Mera I, Sedek AE, El-Monsef A. ULTRASOUND MEASUREMENT OF TRANSCEREBELLAR DIAMETER (TCD)/ABDOMINAL CIRCUMFERENCE (AC) RATIO IN NORMAL AND GROWTH RESTRICTED FETUSES ABOVE TWENTY WEEKS OF GESTATION. Al-Azhar Medical Journal. 2021 Jul 1;50(3):1933-44.
20. Luo H, Liang X, Cheng Z, Cai X, Feng F, Zhou H, Tang X, Zhou J, Wang D, Xiao X. Effects of normal pregnancy on maternal EEG, TCD, and cerebral cortical volume. Brain and Cognition. 2020 Apr 1;140:105526.
21. El-Refaie T, Samy M, Khattab R, Taha Y. Accuracy of fetal transcerebellar diameter in evaluation of fetal gestational age in Egyptian pregnant women. Evidence Based Women's Health Journal. 2022 Feb 1;12(1):86-96.
22. Debbink MP, Son SL, Woodward PJ, Kennedy AM. Sonographic assessment of fetal growth abnormalities. RadioGraphics. 2021 Jan;41(1):268-88.
23. Rosander K, Kaul YF, Holmström G, Westas LH. 4 th Congress of Joint European Neonatal Societies: Brain, Development and Imaging.
24. Carmona-Suazo JA, Navarrete MA, Arguello-Lopez BM, Deloya-Tomas E. Intracranial pressure monitoring and pregnancy. InThe Brain of the Critically Pregnant Woman 2024 Jan 1 (pp. 43-61). Academic Press.
25. Koech A, Musitia PM, Mwashigadi GM, Kinshella ML, Vidler M, Temmerman M, Craik R, von Dadelszen P, Noble JA, Papageorghiou AT, PRECISE Network. Acceptability and Feasibility of a Low-Cost Device for Gestational Age Assessment in a Low-Resource Setting: Qualitative Study. JMIR Human Factors. 2022 Dec 27;9(4):e34823.