A DOUBLE BLIND TRIAL TO COMPARE THE EFFICACY OF VITAMIN E TO A PLACEBO IN THE TREATMENT OF FIBROADENOSIS OF BREAST.
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Keywords
Fibroadenosis, Vitamin E
Abstract
One woman in four is referred to a breast clinic at some time in her life. A breast lump, which may be painful, and breast pain constitute over 80% of the breast problems that require hospital referral, and breast problems constitute up to a quarter of all women in the general surgical workload1.
Fibroadenosis or FBD affects a large number of women during their Reproductive years2. It has been reported to occur in 25% to 50% of women during reproductive life.
Mastalgia the main symptom of Fibroadenosis is a common breast symptom that may affect up to 70% of women in their lifetime3.And is the reason for 50% of all referrals to breast clinics.4
After a thorough history, examination and imaging, reassurance has been reported to have an 85% success rate as a first line treatment in mastalgia5
Many different drugs like Danazol, Tamoxifen, Bromocriptine, have been tried but have been abandoned due to their side effects.
All the clinical trials investigating the possible use of Vitamin E in the treatment of Fibroadenosis of Breast have shown conflicting results.
Thus use of Vitamin E in Fibrocystic Breast Disease is still a debated topic & needs further research to determine its effectiveness.
Therefore this study was undertaken to study the role of Vitamin E in the treatment of Fibroadenosis of Breast. The primary objective of this study was to compare the efficacy of Vitamin E to a placebo in the treatment of Fibroadenosis Breast. The safety and tolerability of Vitamin E are the secondary objectives.
References
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Dr Kiran Prabhakar Rebello
Autonomous State Medical College Sultanpur.
Dr Amol Rebello
Autonomous State Medical College Sultanpur.
Dr. A. K. Singh
Autonomous State Medical College Sultanpur
Dr Anjali Chitale
Department of Surgery, A.C.P.M Medical College, Dhule