PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF ENTEROCOCCUS SPECIES ISOLATED IN CLINICAL SAMPLES FROM A TERTIARY CARE CENTRE
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Keywords
Enterococcus, Vancomycin-resistant Enterococci, Prevalence
Abstract
Objectives:
Enterococci is the part of normal commensals of human intestinal tract which is an important opportunistic pathogens. Arousal of antimicrobial resistance among the enterococci is the main threat to human healthy ecosystem. The present study was carried out to determine the prevalence of antimicrobial resistance among the enterococci i.e. Vancomycin-Resistant Enterococci (VRE) isolated from various clinical samples received from the patients admitted at tertiary care centre at all age group. Early detection, implementing infection control practices to minimize the transmission of infection and antimicrobial stewardship to minimize the arousal of antimicrobial resistance among the enterococci.
Methods:
A one year retrospective study was conducted at a tertiary care centre. Various specimens like pus, urine, blood, body fluid etc. were collected from the patients admitted at tertiary care centre of all age. Culture and antimicrobial sensitivity testing was carried out following standard guideline.
Results:
During the study period of one year, 950 samples were found to be bacterial culture positive out of which 110 (11.6%) isolates were identified as Enterococcus species. Among 110 enterococcal isolates, 80 (72.7%) isolates were Enterococcus faecalis and 30 (27.3%) were Enterococcus faecium. enterococci more frequently isolated from sample collected from male patient 75 (68.2%) than female patients 35 (31.8%). It was more frequently isolated in patients belongs to age group of 35-40 years (34.5%). Isolates were predominantly resistance to tetracycline (80.9%) followed by ciprofloxacin (70%), Benzyl-penicillin (38.2%), high-level aminoglycosides (36.4%), quinupristin-dalfopristin (5.5%) and vancomycin (3.6%), while linezolide and teicoplanin showed the maximum sensitivity. Our study detected the E.faecium more resistant strain to different antibiotics as compared to E. faecalis.
Conclusion:
Our study reports the prevalence of Enterococci isolates as well as of VRE isolates. To reduce the arousal of VRE prevalence worldwide, appropriate use of antibiotics according to antimicrobial susceptibility testing should be encouraged. Efforts should also be made to reduce the transmission of VRE in the hospital.
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Dr. Sachin M Darji
Associate professor, Microbiology department, SIMSR, Kalol
Dr. Jigar R. Katwala
Associate professor, Pharmacology department, SIMSR, Kalol