IMPACT OF ISRADIPINE AS A CALCIUM ANTAGONIST ON ERYTHROPOIETIN, SERUM CALCIUM, AND LUNG FUNCTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
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Keywords
Erythropoietin, Serum, Calcium, Lung Function, Isradipine, Calcium Antagonist
Abstract
Background: Chronic obstructive pulmonary disease (COPD) poses a global health threat, marked by progressive lung function decline and airflow restriction. Erythropoietin (EPO), traditionally associated with hematopoiesis, emerges as a focal point in COPD pathophysiology.
Objective: The study aimed to investigate the interplay between lung function, serum calcium concentrations, and erythropoietin levels in chronic obstructive pulmonary disease (COPD) patients, with a focus on assessing the potential therapeutic advantages of isradipine, a calcium antagonist.
Methodology: The research design integrates cross-sectional observational, 138 COPD-diagnosed individuals were recruited. from diverse healthcare settings. The comprehensive sample collection involved interviews, spirometry assessments, and a 12-week intervention with isradipine or a placebo. Statistical analyses, including descriptive statistics, ANOVA, t-tests, and regression, provided a detailed exploration of these complex relationships.
Results: Smoking, a prevalent COPD risk factor, was noted in over half of the participants. Lung function measures exhibited a substantial decline with increasing COPD severity, particularly in FEV1 and FVC. Isradipine treatment showed a non-significant increase in FEV1 (2.5 to 2.8 liters) and a statistically significant improvement in FVC (3.0 to 3.2 liters) after 12 weeks. Regression analysis unveiled a noteworthy association between elevated blood calcium levels and improved predicted FEV1 (β = 0.25, p = 0.002). Conversely, higher serum erythropoietin levels (β = -0.15, p = 0.011) and escalating COPD severity (β = -0.4, p < 0.001) were linked to diminished predicted FEV1, underscoring their adverse impact on lung function.
Conclusion: Our study highlights the intricate relationships among serum calcium, erythropoietin, and lung function in COPD, offering insights for personalized treatment approaches and future investigations.
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Dr. Syeda Masooma Hussain
Assistant Professor Biochemistry, Rehman Medical College, Peshawar Pakistan
Dr. Tahira Jehangir
Assistant Professor, Pharmacology Department, Nowshera Medical College, Nowshera Pakistan
Dr. Ghazan Askar
Demonstrator, Department of Community Medicine, Northwest School of Medicine, Peshawar Pakistan
Dr. Zara Khalid Khan
Assistant Professor (MBBS, MPhil, CHPE), Department of Biochemistry, Rawal Institute of Health Sciences (RIHS), Islamabad, Pakistan
Dr. Danyal Khattak
Demonstrator, Physiology, KMU Institute of Dental Sciences, Kohat, Pakistan
Dr. Ayesha Jamil
Associate Professor Department of Pharmacology, Khyber Girls Medical College, Peshawar Pakistan#